Patents Assigned to Teikoku Chemical Industry Co., Ltd.
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Patent number: 6831190Abstract: The invention relates to novel and valuable intermediate compounds of the general formula (VIII) which can be used for the preparation of novel compounds comprising an antibacterial action, especially with a strong antibacterial action against helicobacter pylori, and pharmaceutically acceptable salts thereof. In the general formula (VIII) X is hydrogen or halogen, Y is hydrogen or a substituted or unsubstituted aralkyloxycarbonyl group having 8-19 carbon atoms, Z is hydrogen, a substituted aralkyloxycarbonyl group having 8-19 carbon atoms or a substituted alkoxycarbonyyl group having 2-19 carbon atoms, except that X, Y and Z are all hydrogen.Type: GrantFiled: November 22, 2000Date of Patent: December 14, 2004Assignee: Teikoku Chemical Industries Co., Ltd.Inventors: Osamu Kamoda, Hiromichi Fujiwara, Toshiharu Yanagi
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Patent number: 6444703Abstract: The present invention relates to a pharmaceutical composition which is appropriate for eradication or extermination of Helicobacter pylori wherein [4-[4-(4-methylbenzyloxycarbonyl)phenyl[phenyl trans-4-guanidinomethylcyclohexanecarboxylate or an acid addition salt thereof are compounded and it also relates to a complex consisting them.Type: GrantFiled: August 12, 1998Date of Patent: September 3, 2002Assignee: Teikoku Chemical Industries Co., Ltd.Inventors: Osamu Kamoda, Toshiharu Yanagi, Eiji Tamaki, Seiji Sato, Jun-ichi Mizoguchi
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Patent number: 6284791Abstract: A compound represented by general formula (I-2) or a pharmaceutically acceptable acid-addition salt thereof, useful as an anti-microbial against Helicobacter pylori and as a medicinal composition for treating Helicobacter pylori infection, wherein Ar represents phenyl, biphenyl or naphthyl each having a at least one substituent selected from the group consisting of halogen, cyano, nitro, carboxy, C1-C18 alkyl, C1-C18 alkoxy, C3-C18 cycloalkyl, C7-C18 aralkyl, C8-C18 arylalkenyl, C7-C18 aralkyloxy, optionally substituted phenoxy, optionally substituted C2-C19 alkoxycarbonyl, and optionally substituted C8-C19 aralkyloxycarbonyl, provided the case where Ar represents phenyl substituted by halogen, cyano, nitro, carboxy, C1-C18 alkyl, optionally substituted C2-C19 alkoxycarbonyl or C8-C19 aralkyloxycarbonyl is expected.Type: GrantFiled: February 28, 1997Date of Patent: September 4, 2001Assignee: Teikoku Chemical Industries Co., Ltd.Inventors: Osamu Kamoda, Hiromichi Fujiwara, Toshiharu Yanagi
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Patent number: 6103686Abstract: A chelating composition containing an aliphatic polycarboxylic acid of the following formula (I): ##STR1## wherein A is an imino group or an oxygen atom, R is a hydrogen atom or a hydroxyl group, and n is 0 or 1, or the salt thereof and sugar or saccharic acid of 4 to 12 carbon atoms at such a ratio as enables the components to manifest synergistic effects is provided. This chelating composition is capable of effectively sequestering a metal ion and preventing the metal ion from being insolubilized without causing pollution of the environment.Type: GrantFiled: July 16, 1998Date of Patent: August 15, 2000Assignees: Nippon Shokubai Co. Ltd., Teikoku Chemical Industries Co., Ltd.Inventors: Miaki Asakawa, Yasutaka Sumida, Masatoshi Shimomura, Shuichi Okuno, Tadanobu Morimoto, Masanao Morita, Hitoshi Suenaga
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Patent number: 5395552Abstract: A ferroelectric liquid crystal electro-optical device comprises a pair of plates having driving electrodes and ferroelectric liquid crystal material having a negative dielectric anisotropy. The ferroelectric liquid crystal material comprises a ferroelectric liquid crystal composition 10 to 80% by weight of a compound of the general formula: ##STR1## wherein R.sub.1 represents a straight-chain alkyl or alkoxy group, or an alkyl, alkoxy, alkoxyalkyl or acyloxy group each having an asymmetric carbon atom, and R.sub.2 represents a straight-chain alkyl group having an assymmetric carbon.Type: GrantFiled: February 10, 1993Date of Patent: March 7, 1995Assignees: Seiko Instruments Inc., Teikoku Chemical Industry Co., Ltd.Inventors: Hitoshi Suenaga, Masaaki Taguchi
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Patent number: 5231523Abstract: A liquid crystal element has a pair of opposed substrates, electrodes thereon, and a ferroelectric liquid crystal sealed between the substrates. A film of a conductive organic compound or a mixture of a conductive organic compound and another organic compound is disposed on the substrate surface, optionally via an orienting film. The conductive organic compound is typically a charge-transfer complex. The film may be formed by an LB method, coating, vapor phase polymerization or electrolytic polymerization. The element has improved optical bistability, contrast, and response.Type: GrantFiled: August 20, 1992Date of Patent: July 27, 1993Assignees: TDK Corporation, Shunsuke Kobayashi, Teikoku Chemical Industry, Co., Ltd., Japan Carlit Co., Ltd.Inventors: Kenji Nakaya, Shunsuke Kobayashi, Hitoshi Suenaga, Makoto Ebisawa
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Patent number: 5143935Abstract: A benzamide derivative represented by the formula: ##STR1## having a promoting activity of gastrointestinal tract and pharmacentical composition containing the same.Type: GrantFiled: October 16, 1991Date of Patent: September 1, 1992Assignee: Teikoku Chemical Industry Co., Ltd.Inventors: Hiromichi Fujiwara, Akihiko Ogawa, Hideyo Sakiyama, Toshiaki Tamura
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Patent number: 5110496Abstract: An optically active liquid crystal compound which is represented by the formula: ##STR1## wherein R.sub.1 and R.sub.2 each represents an alkyl or aralkyl group of 4-18 carbon atoms, R.sub.3 represents a haloalkyl group, X represents O, COO, OCO, CO or a single bond, Y represents COO, OCO, CH.sub.2 O or OCH.sub.2, Z represents COO or O, (A) represents a cyclic group shown by ##STR2## (B) represents a cyclic group shown by ##STR3## and l shows that the cyclic groups are substituted by at least one halogen atom.Type: GrantFiled: March 1, 1991Date of Patent: May 5, 1992Assignees: Showa Shell Sekiyu Kabushiki Kaisha, Teikoku Chemical Industry Co., Ltd.Inventors: Hiroyuki Mogamiya, Noriko Yamakawa, Yoshiichi Suzuki, Hitoshi Suenaga, Yasuhiro Hasegawa
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Patent number: 4990604Abstract: Method for the production of asialoganglioside related compounds of the formula (I). ##STR1## wherein R.sup.1 is hydrogen or benzoyl, R.sup.2 is hydrogen or acetyl, R.sup.3 is hydrogen, acetyl, .beta.-D-galactopyranosyl or 2,3,4,6-tetra-O-acetyl-.beta.-D-galactopyranosyl, R.sup.7 and R.sup.8 are individually alkyl having 1 to 30 carbon atoms and Ac is acetyl.Type: GrantFiled: February 24, 1986Date of Patent: February 5, 1991Assignees: Rikagaku Kenkyusho, Kanto Ishi Pharmaceutical Co., Ltd., Teikoku Chemical Industry Co., Ltd.Inventors: Tomoya Ogawa, Mamoru Sugimoto, Yoshiyasu Shitori, Toshio Horisaki, Tadami Shinuchi
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Patent number: 4980082Abstract: This invention relates to new optically active pyrimidinylphenyl ester compounds, having a liquid crystal phase of cholesteric and/or smectic C* phase, of the formula: ##STR1## wherein R* represents an optically-active alkyl group having an asymmetric carbon atom which is ##STR2## where R.sup.0 is a straight chain alkyl group of 2 to 6 carbon atoms, R.sup.1 is a straight chain alkyl group of 1 to 5 carbon atoms, R.sup.2 is a straight chain alkyl group of 1 to 2 carbon atoms, R.sup.3 is a straight chain alkyl group of 1 to 6 carbon atoms and n is 0 or 1, R presents a straight-chain alkyl group of 7 or 8 carbon atoms or a straight-chain alkoxy group of 7 or 8 carbon atoms and A represents ##STR3## or --O--.Type: GrantFiled: September 1, 1987Date of Patent: December 25, 1990Assignees: Seiko Instruments Inc., Teikoku Chemical Industry Co., Ltd.Inventors: Kazumasa Ohba, Hiroshi Nonoguchi, Masaaki Taguchi, Takamasa Harada
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Patent number: 4725688Abstract: The present invention is an optically active liquid crystal compound shown in the following general formula; ##STR1## [wherein, A and B respectively show one of --, --O--, ##STR2## (-- shows direct bond), one of R.sub.1 and R.sub.2 shows direct chain alkyl group and the other one shows either alkyl group having asymmetric carbon atom or alkoxy alkyl group having asymmetric carbon atom and ether bonding. Also, onto the asymmetric carbon atom, one of the groups --CH.sub.3, --CN, --Cl is added.]It is clear that there are many compounds in these liquid crystal compounds, that show Sm C* phase in a wide temperature range close to room temperature and that have high response speed.Type: GrantFiled: February 6, 1986Date of Patent: February 16, 1988Assignees: Seiko Instruments Inc., Teikoku Chemical Industry Co., Ltd.Inventors: Masaaki Taguchi, Takamasa Harada, Hitoshi Suenaga
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Patent number: 4710585Abstract: A liquid crystal compound represented by the following general formula:R*O--A--R or R*COO--A--Rwherein R* stands for an alkyl group having an asymmetric carbon atom, R stands for a linear alkyl group, and A stands for ##STR1##Type: GrantFiled: June 10, 1985Date of Patent: December 1, 1987Assignees: Seiko Instruments & Electronics Ltd., Teikoku Chemical Industry Co., Ltd.Inventors: Masaaki Taguchi, Hitoshi Suenaga
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Patent number: 4643842Abstract: A liquid crystal composition comprising at least one optically active liquid crystal compound represented by the following general formula: ##STR1## wherein R.sub.2 stands for a linear alkyl group and R.sub.1 * stands for an alkoxy or acyloxy group having an asymmetric carbon atom,and at least one optically active liquid crystal compound represented by the following general formula: ##STR2## wherein R.sub.3 * stands for an alkyl group having an asymmetric carbon atom and R.sub.4 stands for a linear alkyl group.Type: GrantFiled: March 28, 1985Date of Patent: February 17, 1987Assignees: Seiko Instruments & Electronics Ltd., Teikoku Chemical Industry Co., Ltd.Inventors: Masaaki Taguchi, Hitoshi Suenaga
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Patent number: 4633012Abstract: A liquid crystal compound represented by the following general formula: ##STR1## wherein m is a number from 0 to 10, n is a number from 5 to 14, and C having an asterisk indicates an asymmetric carbon atom.Type: GrantFiled: June 10, 1985Date of Patent: December 30, 1986Assignees: Seiko Instruments & Electronics Ltd., Teikoku Chemical Industry Co., Ltd.Inventors: Masaaki Taguchi, Takamasa Harada, Hitoshi Suenaga
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Patent number: 4478995Abstract: A complex of an acid addition salt of (2'-benzyloxycarbonyl)phenyl trans-4-guanidinomethylcyclohexanecarboxylate and a cyclodextrin. The complex is useful for the treatment of ulcers.Type: GrantFiled: August 27, 1982Date of Patent: October 23, 1984Assignee: Teikoku Chemical Industry Co., Ltd.Inventors: Masamitu Shinoda, Ikuo Tanaka, Tadahiko Yasuda, Isao Nakajima, Tutomu Adachi, Giichi Ikeda
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Patent number: 4348410Abstract: A compound of the formula: ##STR1## wherein R.sub.1 represents a vanilyl, napthyl, pyridyl or .alpha.-tocopheryl group, or a group of the formula, ##STR2## wherein R.sub.2 represents a hydrogen atom, a lower alkoxy, formyl, lower alkanoyl or phenyl group, or a group of the formula --(CH.sub.2).sub.n COOR.sub.3, wherein R.sub.3 represents a hydrogen atom, a lower alkyl, phenyl, benzyl, anisyl or lower alkoxycarbonylmethyl group, and n represents an integer of 0 to 2, or a pharmaceutically acceptable salt thereof is effective for use as an anti-ulcer agent.Type: GrantFiled: September 15, 1980Date of Patent: September 7, 1982Assignees: Nippon Chemiphar Co., Ltd., Teikoku Chemical Industry Co., Ltd.Inventors: Mutsumi Muramatsu, Toshio Satoh, Yukio Yanagimoto, Tadami Shinuchi, Toshio Nakajima, Isao Nakajima
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Patent number: 3983134Abstract: Ureylenethiophanes and their related compounds of the formula: ##SPC1##Having a cis-configuration on the ureylene or thioureylene juncture, which are useful as the intermediates in the synthesis of biologically active biotin and its related compounds, can be produced selectively by reacting the corresponding compounds of the formula: ##SPC2##With isocyanates or isothiocyanates wherein R is a hydrogen atom, an alkyl group or an aralkyl group, R.sub.1 and R.sub.2 are each a hydrogen atom or an aliphatic hydrocarbon group bearing or not a carboxyl group or any other group convertible thereto at the terminal position, X is a halogen atom, Y is an oxygen atom or a sulfur atom and Z is an oxygen atom, a sulfur atom, a sulfinyl group or a sulfonyl group.Type: GrantFiled: August 5, 1975Date of Patent: September 28, 1976Assignee: Teikoku Chemical Industry Co., Ltd.Inventors: Masanao Matsui, Kenji Mori, Takeshi Kitahara, Seiichi Kitamura, Kazumasa Ohba
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Patent number: 3962267Abstract: The dental cement composition comprises an aqueous resin composition prepared by the copolymerization of 3-butene-1,2,3-tricarboxylic acid and an .alpha.,.beta.-olefinic unsaturated monocarboxylic acid and, when desired, an additional polymerizable monomer as well as a metal oxide. The dental cement composition possesses compressive strength.Type: GrantFiled: July 11, 1974Date of Patent: June 8, 1976Assignees: Shofu Dental Corporation, Teikoku Chemical Industry Co., Ltd.Inventors: Narishige Suzuki, Yoshihiro Morino, Yoshitaka Hashiguchi, Tunehiro Segawa
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Patent number: 3939202Abstract: Polyene compounds of the formula: ##EQU1## wherein R' is protected or unprotected hydroxyl or a group of the formula: ##EQU2## (in which R" and R"' are each carboxyl or a group convertible into carboxyl on hydrolysis), m is a positive integer and n is 0 or a positive integer, which are useful as intermediates in the synthesis of coenzyme Q, can be produced advantageously through a step for the dehydration of a compound of the formula: ##EQU3## wherein R', m and n are each as defined above.Type: GrantFiled: January 29, 1974Date of Patent: February 17, 1976Assignee: Teikoku Chemical Industry Co., Ltd.Inventors: Masanao Matsui, Seiichi Kitamura, Masahiro Morioka