Abstract: It is provided the plaster of anti-inflammatory and analgesic, improving the sustained releasing of 4-biphenylacetic acid from the base adhesive material and low skin irritation, by using more than two kinds of resolvent for 4-biphenylacetic acid having low solubility in solvents. More specifically, it is provided plasters essentially containing 5–50% by weight of styrene-isoprene-styrene block copolymer, 0.05–20% by weight of N-methyl-2-pyrrolidone, 0.1–20% by weight of polyethylene glycol and 0.1–20% by weight of 4-biphenylacetic acid.