Patents Assigned to Teikoku Seiyaku Co., Ltd.
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Patent number: 9579297Abstract: Since treatment effects of conventional external preparations were not satisfactory, it is aimed to provide a novel external preparation that is excellent in drug permeability to nail, capable of fully exhibiting effects of an antifungal drug, and effective for treatments of diseases such as nail mycosis and nail candidiasis, particularly, treatments for nail tinea. The external preparation of this invention is a pharmaceutical composition for nail characterized by containing an antifungal drug, alkylpyrrolidone or a derivative thereof, and a crosslinking hydrogel.Type: GrantFiled: December 26, 2006Date of Patent: February 28, 2017Assignee: TEIKOKU SEIYAKU CO., LTD.Inventors: Tomohiro Ishima, Mamoru Naruse, Hideo Kaneda, Kazuo Kanai, Takashi Sekine, Shinichi Ota, Tomonari Yoshimura
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Patent number: 9517331Abstract: An iontophoresis patch is equipped with a donor gel and a reference gel which are disposed to contact an external conductor, for example, the skin of a patient and thereby output current from a current-carrying device to the external conductor. The iontophoresis patch includes: a donor portion having the donor gel containing a medical agent to be penetrated into the external conductor; a reference portion having a reference gel, mounted with the current-carrying device on the surface on the side opposite to the reference gel, and disposed on the external conductor apart from the donor portion; and an electrode film for supplying current from the current-carrying device to the donor gel and the reference gel.Type: GrantFiled: February 9, 2011Date of Patent: December 13, 2016Assignees: TERUMO KABUSHIKI KAISHA, TEIKOKU SEIYAKU CO., LTD.Inventors: Mitsutoshi Yaegashi, Akihiro Hasui, Hiroyuki Kubo
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Patent number: 9517211Abstract: A patch for external use which has a laminate structure comprising a substrate and a pressure-sensitive adhesive layer which contains a styrene/isoprene/styrene block copolymer as the base and further contains a tackifier resin consisting of a rosin resin and at least one other tackifier resin, a softening agent consisting of polybutene and liquid paraffin, a fatty acid ester, and fentanyl, characterized in that the weight ratio of the rosin resin to fentanyl is 1 to 5, the weight ratio of the rosin resin to the whole tackifier resin is 0.1 to 0.6, and the tackifier resin accounts for 30 to 60wt % of the whole pressure-sensitive adhesive layer. The patch is excellent in the permeation of fentanyl through the skin and in storage stability, and is weak in irritation to skin.Type: GrantFiled: January 26, 2009Date of Patent: December 13, 2016Assignee: TEIKOKU SEIYAKU CO., LTD.Inventors: Kunihiko Matsushita, Mamoru Naruse, Kenichi Hattori
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Patent number: 9457012Abstract: A transdermal absorption preparation comprising (1) a support, and (2) a rubber-based adhesive layer comprising 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutylamide or a pharmaceutically acceptable salt thereof, oleic acid, capric acid and crotamiton, wherein the rubber-based adhesive layer is formed on a surface of the support. The transdermal absorption preparation exhibits excellent transdermal absorption of the 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutylamide or salt thereof.Type: GrantFiled: March 21, 2013Date of Patent: October 4, 2016Assignee: TEIKOKU SEIYAKU CO., LTD.Inventors: Masato Watanabe, Norihiro Kanayama
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Patent number: 9433772Abstract: The present invention provides an electrode device used in iontophoresis treatment, in which an electrode layer used for introduction of medication can be contacted to a medication reservoir layer with a simple manner, and in which the medication reservoir layer can be reliably held when the medication is introduced into a skin. A main-electrode layer 3 and a sub-electrode layer 1 are secured on a substrate 6 while both the layers are being insulated from each other. The main-electrode layer 3 is intended for introduction of the medication, and the sub-electrode layer 1 is provided to hold the medication reservoir layer 5 on the substrate 6. The medication reservoir layer 5 is located on the substrate 6, so as to be in contact with the main-electrode layer 3 and the sub-electrode layer 1. The medication reservoir layer 5 is a gel containing halogen compound, and the sub-electrode layer 1 comprises a metal having a lower ionization tendency than hydrogen.Type: GrantFiled: December 17, 2010Date of Patent: September 6, 2016Assignee: TEIKOKU SEIYAKU CO., LTD.Inventor: Akihiro Hasui
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Publication number: 20160193178Abstract: The present invention provides a patch containing beraprost or a pharmacologically acceptable salt thereof, which achieves high transdermal absorption of beraprost or a pharmacologically acceptable salt thereof and has excellent formulation properties.Type: ApplicationFiled: August 7, 2014Publication date: July 7, 2016Applicant: TEIKOKU SEIYAKU CO., LTD.Inventors: Satoshi KAWAKAMI, Manabu SOGABE, Taiki SHIBATA
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Patent number: 9375422Abstract: Disclosed is a fentanyl-containing adhesive preparation for external use, wherein an adhesive layer is laminated on a supporting body. The adhesive layer contains SIS, a tackifier resin that is composed of a rosin resin and terpene resin, and a softener that is composed of a plybutene and a liquid paraffin. The adhesive layer also contains fentanyl as an active ingredient. The fentanyl-containing adhesive preparation for external use has excellent skin permeation of fentanyl and high preparation stability, without suffering from crystallization of fentanyl during storage.Type: GrantFiled: July 21, 2010Date of Patent: June 28, 2016Assignee: TEIKOKU SEIYAKU CO., LTD.Inventors: Mamoru Naruse, Kenichi Hattori, Kunihiko Matsushita
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Patent number: 9364428Abstract: A Chinese herbal medical composition in the form of jelly, wherein a Chinese herbal medicine is contained in a base containing at least one substance selected from the group consisting of carrageenan, carob bean gum and xanthan gum and not containing phosphate buffer. The Chinese herbal medical composition hardly causes syneresis, is superior in the preservative stability, is broadly applicable to a Chinese herbal medicine and is orally taken without taking care of the bitter of a Chinese herbal medicine.Type: GrantFiled: July 28, 2003Date of Patent: June 14, 2016Assignee: TEIKOKU SEIYAKU CO., LTD.Inventors: Tsunehiro Fukuchi, Koji Matsuura, Noboru Tatsumi, Masatake Dairaku, Mitsuo Togashi
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Patent number: 9271944Abstract: Provided is a water-based patch that contains ketoprofen as an active ingredient, provides high transdermal absorbability of the ketoprofen, and has high safety and high storage stability. The water-based patch contains the ketoprofen, an amine, and polyethylene glycol. In the water-based patch, the added amount of the ketoprofen in a paste is 0.1 to 5% by weight, the added amount of the amine in the paste is 0.5 to 10% by weight, and the added amount of the polyethylene glycol in the paste is 5 to 30% by weight. Particularly, in the water-based patch, diisopropanolamine is used as the amine.Type: GrantFiled: March 11, 2011Date of Patent: March 1, 2016Assignee: Teikoku Seiyaku Co., Ltd.Inventor: Kazuha Tani
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Patent number: 9205060Abstract: Provided is a transdermal absorption-type patch containing a serotonin receptor antagonist, which has a short transdermal absorption delay time (lag time), and in which the maximum transdermal permeation rate of the drug can be reached within a short time and the drug can disappear from circulating blood rapidly. That is, provided is a patch containing a serotonin receptor antagonist, wherein the patch contains an adhesive layer comprising a non-functional acrylic adhesive, a water-soluble organic amine, a fatty acid ester, and a serotonin receptor antagonist such as granisetron as an active ingredient.Type: GrantFiled: July 4, 2012Date of Patent: December 8, 2015Assignee: Teikoku Seiyaku Co., Ltd.Inventors: Takashi Kamakura, Daiki Takano
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Patent number: 9168235Abstract: An aqueous patch containing diclofenac sodium, wherein the patch contains a homogeneous mixed solution of diclofenac sodium, wherein the solution is obtained by mixing crotamiton, diclofenac sodium and water in the mixture ratio of crotamiton/diclofenac sodium of 8.0 or less and the mixture ratio of (water+crotamiton)/diclofenac sodium of 3.0-20.0.Type: GrantFiled: October 19, 2010Date of Patent: October 27, 2015Assignee: Teikoku Seiyaku Co., Ltd.Inventors: Takashi Kamakura, Kazuha Tani, Yuichiro Mabuchi, Kazuhito Okada
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Patent number: 9149443Abstract: A tape preparation is provided which does not use a backing such as a plastic film, knit or a woven fabric, or a nonwoven fabric, has very high conformability to skin, and is easy to use at the time of application. There is provided a tape preparation 1 that is produced by laminating a drug-containing adhesive layer 4 on the printed ink layer 3 side of a cover film 2 with printing thereon and covering the drug-containing adhesive layer with a release film 5. In this tape preparation, the adhesive strength between the cover film and the printed ink layer is higher than the adhesive strength between the drug-containing adhesive layer and the release film, and the adhesive strength between the printed ink layer and the drug-containing adhesive layer is higher than the adhesive strength between the cover film and the printed ink layer.Type: GrantFiled: December 14, 2010Date of Patent: October 6, 2015Assignee: Teikoku Seiyaku Co., Ltd.Inventor: Masanori Uematsu
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Publication number: 20150246215Abstract: An iontophoresis patch which outputs an electric current from an energizing device to an external conductor comprises: a donor portion that has a first contact member; a reference portion that has a second contact member and is located on the external conductor away from the donor portion; and an electrode body that has a first electrode and a second electrode and that extends across the donor portion and the reference portion. The electrode body has a single-sided wiring structure in which the first electrode and the second electrode are formed by a conductive ink being printed on one side of a film, the printing pattern of the first electrode has a gap area in which the conductive ink is not printed, and the film and the first contact member are transparent.Type: ApplicationFiled: December 25, 2012Publication date: September 3, 2015Applicants: TEIKOKU SEIYAKU CO., LTD., TERUMO KABUSHIKI KAISHAInventors: Mitsutoshi Yaegashi, Akihiro Hasui
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Patent number: 9119861Abstract: An adhesive patch is provided in which piroxicam is formulated as a non-steroidal anti-inflammatory analgesic. In particular, provided is a piroxicam-containing transdermally absorbable adhesive patch in which an absorption promoter to piroxicam is formulated to achieve high anti-inflammatory and analgesic effects without inhibiting releasing of these drugs. The piroxicam-containing transdermally absorbable adhesive patch contains piroxicam as a medicinal component and oxybuprocaine or a pharmaceutically acceptable salt thereof as an absorption promoter. In the piroxicam-containing transdermally absorbable adhesive patch, the content of piroxicam is from 0.1% to 5% by weight to the total weight of a drug-containing plaster and the content of oxybuprocaine or the pharmaceutically acceptable salt thereof is from 1% to 30% by weight to the total weight of the drug-containing plaster.Type: GrantFiled: December 14, 2010Date of Patent: September 1, 2015Assignee: Teikoku Seiyaku Co., Ltd.Inventors: Akiko Katayama, Katsuyuki Inoo
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Patent number: 9120956Abstract: Provided is a water-based plaster in which the gel strength is maintained to an appropriate level in a step of producing the water-based plaster, and particularly in a spreading step and an aging step, and a final preparation can exhibit an optimal adhesiveness for adhering to the skin. In the water-based plaster, a water-based adhesive base containing a water-soluble polymer as a main ingredient contains a higher fatty acid which is a liquid at room temperature and a viscosity of 1,000 (mPa·s, 20° C.) or more as a crosslinking modifier. The higher fatty acid is isostearic acid, and the contained amount thereof is 1 to 10% by weight.Type: GrantFiled: July 18, 2012Date of Patent: September 1, 2015Assignee: Teikoku Seiyaku Co., Ltd.Inventors: Kazuha Tani, Takashi Kamakura
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Patent number: 8974817Abstract: Disclosed is a novel transdermally absorbable preparation which enables the efficient, stable and long-term administration of a drug to a living body. More specifically, the transdermally absorbable preparation comprises: a laminate comprising an outer film, a drug-containing layer and a support layer laminated in this order from the side to be contacted with the skin; and a fixing means for fixing the laminate on the skin. In the transdermally absorbable preparation, the outer film is a drug-permeable polymer film that can control the release of the drug into the skin and is provided as a surface of the laminate which is to be contact with the skin.Type: GrantFiled: March 25, 2009Date of Patent: March 10, 2015Assignee: Teikoku Seiyaku Co., Ltd.Inventors: Takeshi Ito, Miho Ishigure
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Patent number: 8932626Abstract: An adhesive patch is a felbinac-containing transdermally absorbable preparation substantially free of a solubilizer for felbinac in a final preparation but still having high releasing of felbinac. The adhesive patch in which lidocaine and felbinac are formulated has the releasing of felbinac without losing the releasing of lidocaine. The felbinac-containing transdermally absorbable adhesive patch contains felbinac as an active component and lidocaine or a pharmaceutically acceptable salt thereof as an absorption promoter. In particular, the content of felbinac is from 0.1% to 10% by weight to the total weight of the drug-containing plaster and the content of lidocaine or the pharmaceutically acceptable salt thereof is from 0.01% to 20% by weight to the total weight of the drug-containing plaster.Type: GrantFiled: December 14, 2010Date of Patent: January 13, 2015Assignee: Teikoku Seiyaku Co., Ltd.Inventors: Akiko Katayama, Katsuyuki Inoo
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Patent number: 8840922Abstract: Provided is a donepezil-containing transdermal absorption formulation that can sustainably administer donepezil for a long period of time, and can provide both a rapid increase in the blood level of donepezil and donepezil sustained release properties. The donepezil-containing transdermal absorption formulation is a transdermal absorption formulation produced by dissolving donepezil, which is the active ingredient, in an adhesive patch base that contains a hydrophobic polymer and an absorption promoter. The absorption promoter is one kind or two or more kinds selected from lauryl alcohol, triethyl citrate, isopropyl myristate, cetyl lactate, oleyl alcohol, sorbitan monooleate, polyethylene glycol monostearate, lauromacrogol, N-methyl-2-pyrrolidone, and triacetin.Type: GrantFiled: October 18, 2010Date of Patent: September 23, 2014Assignee: Teikoku Seiyaku Co., Ltd.Inventors: Satoshi Kawakami, Masahiro Yamaji
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Publication number: 20140234396Abstract: The present invention provides to patches having excellent skin-permeability and therapeutic effect by the drug with lower irritation. In an external patch in which an adhesive layer containing an adhesive base and a drug are laminated with a backing, the external patch wherein the adhesive base contains 5-50% by weight of synthetic rubber polymer, 10-60% by weight of adhesive resin and 25-60% by weight of liquid paraffin, and the drug is etofenamate. According to the present invention, there is obtainable the patches having excellent skin-permeability and therapeutic effect by the drug with lower irritation.Type: ApplicationFiled: April 29, 2014Publication date: August 21, 2014Applicants: TEIKOKU SEIYAKU CO., LTD., DROSSAPHARM AGInventors: Tomohiro ISHIMA, Hiroyuki YAMASAKI, Masahiro YAMAJI
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Patent number: D747455Type: GrantFiled: February 22, 2013Date of Patent: January 12, 2016Assignee: Teikoku Seiyaku Co., Ltd.Inventor: Masanori Uematsu