Abstract: Methods for administering a dermatological agent to a subject are provided. In the subject methods an effective amount of a topical formulation of the dermatological agent is topically applied to a host. The topically applied formulation of dermatological agent is then occluded with a hydrogel patch, where a feature of the hydrogel patch is that it lacks a pharmaceutically active agent. Also provided are methods of treating a subject for a disease condition by administering a dermatological agent to the subject. Also provided are kits for use in practicing the subject methods. The subject methods and compositions find use in a variety of different applications.

Abstract: Methods for administering a dermatological agent to a subject are provided. In the subject methods an effective amount of a topical formulation of the dermatological agent is topically applied to a host. The topically applied formulation of dermatological agent is then occluded with a hydrogel patch, where a feature of the hydrogel patch is that it lacks a pharmaceutically active agent. Also provided are methods of treating a subject for a disease condition by administering a dermatological agent to the subject. Also provided are kits for use in practicing the subject methods. The subject methods and compositions find use in a variety of different applications.

Abstract: Methods for administering a dermatological agent to a subject are provided. In the subject methods an effective amount of a topical formulation of the dermatological agent is topically applied to a host. The topically applied formulation of dermatological agent is then occluded with a hydrogel patch, where a feature of the hydrogel patch is that it lacks a pharmaceutically active agent. Also provided are methods of treating a subject for a disease condition by administering a dermatological agent to the subject. Also provided are kits for use in practicing the subject methods. The subject methods and compositions find use in a variety of different applications.

Abstract: The invention relates to azelastine hydrochloride-containing percutaneous preparations which comprises, as base ingredients; hydrocarbon and/or beeswax, and a surfactant.

Abstract: The present invention relates to an improved intravaginal preparation containing a physiologically active peptide, which comprises a physiologically active peptide, a sucrose fatty acid ester and an organic acid with a pharmaceutically acceptable carrier or diluent, by which the physiologically active peptide can be absorbed safely and efficiently.

Abstract: A pharmaceutical composition comprising a physiologically active polypeptide, an absorption promoting agent consisting of a combination of an organic acid and a fatty acid sucrose ester in admixture with a pharmaceutically acceptable carrier or diluent, which is suitable for oral administration and for application to the oral cavity, by which the polypeptide can sufficiently be absorbed through the intestinal tract or the mucous membrane in the oral cavity and exhibit the physiological activities without being suffered from enzymolysis.

Abstract: A drug for the treatment of skin injuries, particularly hardly curable diseases such as bedsore, which comprises as an active ingredient acetylsalicylic acid. The drug is used in the form of a topical preparation for external application or is administered orally to the patients.

Abstract: An external preparation for application to the skin containing lidocaine which comprises a drug-retaining layer placed on a support, wherein said drug-retaining layer comprises an adhesive gel base and 1 to 10% by weight of lidocaine, said base comprising a water-soluble high molecular weight substance, water and a water-retaining agent, which can release the active lidocaine gradually and constantly so that lidocaine is transdermally absorbed for a long period of time.

Abstract: The present invention relates to an improved intravaginal preparation containing a physiologically active peptide, which comprises a physiologically active peptide, a sucrose fatty acid ester and an organic acid with a pharmaceutically acceptable carrier or diluent, by which the physiologically active peptide can be absorbed safely and efficiently.

Abstract: A physiologically active substance well capable of permeating biomembrane according to the present invention is represented by: ##STR1## where R represents a residue of a physiologically active substance comprising a peptide, amino acid, aliphatic amine having a phenol skeleton, amino sugar, nucleoside or lactam compound and a residue of physiologically active derivative thereof. The biomembrane permeability of a substance with poor biomembrane permeability can be improved by introducing an adamantyl group to the physiologically active substance.

Abstract: An oral pharmaceutical preparation of a type released at infragastrointestinal tract was successfully prepared, wherein a solid organic acid dissolvable, in the form of a solution, of chitosan and a solid pharmaceutical preparation including a principal agent are filled in a hard capsule composed of the base principally comprising chitosan and an enteric coating is formed on the surface of the hard capsule, characterized in that a desirable releasing time can be arranged, with no pH dependency, via water permeability derived from the porosity of chitosan of the capsule preparation.

Abstract: An acid heteropolysaccharide P-318 which comprises galactose, galacturonic acid, N-acetylfucosamine and pyruvic acid in a ratio of about 2:3:1:1, a sulfated heteropolysaccharide P-318 having a 10% or less sulfur content which is prepared by sulfating said acid heteropolysaccharide and a process for preparing an acid heteropolysaccharide P-318 which comprises culturing Pseudomonas sp. 318 to produce the acid heteropolysaccharide P-318 and collecting the thus produced acid heteropolysaccharide P-318. The sulfated polysaccharide P-318 of the invention shows a strong antiviral activity in spite of a lower content of sulfate.

Abstract: A high-absorbable transvaginal preparation having excellent absorbability of the active ingredient, which comprises a biologically active polypeptide and an absorption promoter comprising a polyoxyethylenealkylphenyl ether and one or more compounds selected from the group consisting of an N-acylamino acid, cholic acids, pectic acid, taurine, saccharin, glycyrrhizic acid, aspartame, or a salt thereof.

Abstract: A preparation for intermittently releasing an active agent which comprises a laminated combination of a release-controlling layer and a pharmaceutically active agent-containing layer wherein one or more of pharmaceutically active agent layers are incorporated into said release-controlling layer. The preparation in accordance with the present invention can intermittently control the release of the active agent to decrease a dosage time and is applicable to the mucous membrane or gingivae within the oral cavity.

Abstract: A drug reservoir containing an active substance such as a drug is formed on an adhesive layer which can adhere to an oral mucosal membrane. A polymer, which does not dissolve with saliva, is further coated on the drug reservoir as a drug release controlling layer to form an entire oral cavity sustained release dosage form. A drug impermeable layer can be formed between the adhesive layer and the drug reservoir.

Abstract: A plaster, which can be used in the prevention of attacks of bronchial asthma and in the treatment of bronchitis, comprises an adhesive base composition comprising a macromolecular substance and a sequestering agent and containing salbutamol, and a support for supporting the adhesive base composition spread thereon, and a method of producing the plaster are provided.

Abstract: An adhesive tape usable as an analgesic and antiinflammatory agent comprises a support member and an adhesive mass spread on the support member, which mass contains, as essential components, etofenamate as the active ingredient, a styrene-isoprene-styrene block copolymer as an adhesive ingredient, a tackifier resin, liquid paraffin as a softening agent, a liquid rubber as a softening agent and further an antioxidant.

Abstract: A drug reservoir containing an active substance such as a drug is formed on an adhesive layer which can adhere to an oral mucosal membrane. A polymer, which does not dissolve with saliva, is further coated on the drug reservoir as a drug release controlling layer to form an entire oral cavity sustained release dosage form. A drug impermeable layer can be formed between the adhesive layer and the drug reservoir.

Abstract: A sheet-shaped adhesive preparation comprising an adhesive layer containing as essential components a carboxyvinyl polymer, a water-insoluble methacrylic copolymer, a polyhydric alcohol and a pharmaceutically active agent, and a water-impermeable and water-insoluble carrier layer containing as essential components a pharmaceutically acceptable water-insoluble, film-forming high molecular weight compound and a plasticizer, which can adhere within the oral cavity for a longer period of time and can release the active agent and hence is useful as a sustained release preparation for the oral cavity.

Abstract: A sheet-like preparation comprising a composition comprising (a) a drug, (b) gelatin or agar, (c) gluten, (d) a carboxyvinyl polymer, (e) a polyhydriic alcohol, (f) a gum and (g) wax as its essential constituents, and water in an amount of 0 to 30 w/w % based on the total weight of the essential constituents, and a sheet-like support which supports thereon said composition.The sheet-like preparation of this invention is useful, for example, as a preparation for oral cavity administration.