Patents Assigned to TEIKYO UNIVERSITY
  • Patent number: 12207875
    Abstract: An eye movement analysis system includes an image-capturing unit configured to capture a moving image including at least one of a right eye and a left eye of a subject and a comparison target on a surface of a face of the subject, and an analysis unit configured to analyze a movement of an eyeball of the at least one of the right eye and the left eye of the subject, based on a relationship between the at least one of the right eye and the left eye of the subject and the comparison target on the moving image captured by the image-capturing unit.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: January 28, 2025
    Assignee: TEIKYO UNIVERSITY
    Inventors: Kakeru Sasaki, Takao Hayashi
  • Patent number: 12178859
    Abstract: The present invention provides a method for treating or preventing inflammation caused by neutrophils and a pharmaceutical composition for such treatment or prevention. Specifically, provided is a pharmaceutical composition or the like for treating or preventing inflammation caused by neutrophils that contains a complex in which lysozyme and chitosan are bonded.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: December 31, 2024
    Assignees: WAKO FILTER TECHNOLOGY CO., LTD., TEIKYO UNIVERSITY
    Inventors: Hiroki Kageshima, Yoichi Murakami, Akira Saito, Shigeru Abe, Kazumi Hayama, Naho Maruyama
  • Publication number: 20240411119
    Abstract: An intraocular illumination device includes a fiber that guides light from a light source, and a holder that is disposed between an objective lens of a microscope and an eye during eye surgery or examination and supports a tip portion of the fiber. The tip portion of the fiber is provided with a reflecting portion that reflects the light guided through the fiber toward an inside of the eye.
    Type: Application
    Filed: October 21, 2022
    Publication date: December 12, 2024
    Applicants: UNIVERSITY OF TSUKUBA, TEIKYO UNIVERSITY
    Inventors: Shohei MORIKAWA, Toshifumi MIHASHI
  • Patent number: 11932595
    Abstract: Provided are vitamin D3 derivatives of formula (I), pharmaceutical compositions thereof, and pharmaceutical or medical uses thereof for treating metabolic disease, a liver disease, obesity, diabetes, cardiovascular disease, or cancer in a patient in need thereof.
    Type: Grant
    Filed: September 17, 2021
    Date of Patent: March 19, 2024
    Assignee: KYOTO UNIVERSITY, NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY, TEIKYO UNIVERSITY and THE UNIVERSITY OF TOKYO
    Inventors: Motonari Uesugi, Yasushi Takemoto, Kazuo Nagasawa, Atsushi Kittaka, Fumihiro Kawagoe, Hayato Nakagawa
  • Patent number: 11936338
    Abstract: A method for estimating an operation voltage of a cell includes setting a state in which one cell is shielded from light; detecting a small change of an output current of a module in that state; irradiating another cell with modulated and detecting the small change of the output current light in that state; detecting an operation voltage of the module in that state; generating a first calibration line by connecting a first point and a second point which are plotted on coordinate axes representing a voltage and a relative ratio of a resistor; irradiating a cell the operation voltage of which is to be estimated with the modulated light and detecting the small change of the output current of the module in a state in which none of the cells is shielded from light; detecting the operation voltage of the module in that state; generating a second calibration line by connecting a third point and the second point which are plotted on the coordinate axes; calculating a value of the relative ratio of the resistor of the
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: March 19, 2024
    Assignee: TEIKYO UNIVERSITY
    Inventors: Yasuyuki Kobayashi, Shunsuke Kisu
  • Patent number: 11753689
    Abstract: A method for detecting Candida auris, including subjecting a nucleic acid sample obtained from a specimen to a nucleic acid amplification reaction by the LAMP method and detecting an amplification product, wherein, in the primer set to be used in the LAMP method, FIP is a polynucleotide including 5 to 20 nucleotides located on the 5?-terminal side and 5 to 20 nucleotides located on the 3?-terminal side in the nucleotide sequence represented by SEQ ID NO: 1, BIP is a polynucleotide including 5 to 20 nucleotides located on the 5?-terminal side and 5 to 20 nucleotides located on the 3?-terminal side in the nucleotide sequence represented by SEQ ID NO: 2, F3 is a polynucleotide including SEQ ID NO: 3, and B3 is a polynucleotide including SEQ ID NO: 4.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: September 12, 2023
    Assignee: TEIKYO UNIVERSITY
    Inventors: Koichi Makimura, Mikachi Yamamoto, Mohamed Mahdi Alshahni
  • Publication number: 20230272388
    Abstract: Provided a novel miR-96-5p inhibitor that is more effective than an antisense oligonucleotide against miR-96-5p, and a novel pharmaceutical composition comprising the same. The miR-96-5p inhibitor comprises a peptide nucleic acid moiety comprising a nucleotide sequence complementary to miR-96-5p.
    Type: Application
    Filed: July 29, 2021
    Publication date: August 31, 2023
    Applicant: TEIKYO UNIVERSITY
    Inventors: Toshio NAKAKI, Koji AOYAMA, Chisato KINOSHITA, Nobuko MATSUMURA, Kazue UTSUMI, Toru SUGIYAMA, Shun-suke MORIYA
  • Publication number: 20230077422
    Abstract: According to an embodiment, there are provided a screening culture medium that enables a convenient and quick examination for the presence of Candida auris, and a screening method. According to at least one embodiment, the screening culture medium contains an enzyme substrate, in which the screening culture medium is used for screening Candida auris based on an ability to degrade the enzyme substrate, the enzyme substrate including raffinose and xylose. According to another embodiment, the screening method uses the screening culture medium.
    Type: Application
    Filed: February 1, 2021
    Publication date: March 16, 2023
    Applicant: TEIKYO UNIVERSITY
    Inventors: Koichi MAKIMURA, Takashi TAMURA
  • Patent number: 11560602
    Abstract: The present invention has an object to provide a simpler and quicker method for diagnosing tinea, method for detecting a Trichophyton, or method for detecting the Trichophyton gene. Use of at least four kinds of specific primers each designed based on a DNA sequence of the Trichophyton gene makes it possible to simply and quickly detect the Trichophyton gene.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: January 24, 2023
    Assignees: SATO PHARMACEUTICAL CO., LTD., TEIKYO UNIVERSITY
    Inventors: Koichi Makimura, Kazuo Satoh, Yoshiharu Miyajima
  • Patent number: 11475578
    Abstract: Even for the case where cells such as human epidermal keratinocytes form a dense colony, or the case where cell contours are indefinite, each of the cells is automatically tracked with high precision, and behavior of each cell is analyzed with good precision. There is provided a method for analyzing behavior of a cell, which comprises a detection step of detecting positions of a plurality of cells for every frame of time-lapse images, while determining whether a candidate region extracted from the frame is a cell region by using a dictionary containing image data of cell nuclei; and a tracking step of tracking each cell by using a state space model using position of a most adjacent cell within a predetermined distance from a predicted position as observation data. When any cell is not found within a certain distance from the predicted position, data are considered missing.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: October 18, 2022
    Assignee: TEIKYO UNIVERSITY
    Inventors: Junichi Kotoku, Takuya Hirose, Daisuke Nanba, Emi Nishimura
  • Patent number: 11464403
    Abstract: A tracheal tube insertion aid kit (1) assists in inserting a tracheal tube (9) from an oral cavity (B) of a patient (A) into an endotracheal space (E) through a glottis (D) using an indirect glottis viewing type laryngoscope (2) not equipped with the tracheal tube (9). The tracheal tube insertion aid kit (1) includes a guide tube (11) having flexibility and formed to be insertable into the endotracheal space (E) from the oral cavity (B) through the glottis (D), and a guide wire (12) formed to be insertable through the inside of the guide tube (11) and insertable into the endotracheal space (E) from the oral cavity (B) through the glottis (D).
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: October 11, 2022
    Assignee: TEIKYO UNIVERSITY
    Inventor: Yoshiki Hara
  • Publication number: 20220098646
    Abstract: A detection method for pan-resistant K. pneumoniae comprising of: performing complete genome analysis of the bacteria contained in the sample; and comparing a nucleotide sequence contained in the obtained complete genome with nucleotide sequences of SEQ ID NO: 1 or 2, and determining whether or not the bacteria in the sample is pan-resistant K. pneumoniae based on the rate of agreement.
    Type: Application
    Filed: November 15, 2019
    Publication date: March 31, 2022
    Applicant: TEIKYO UNIVERSITY
    Inventors: Satoshi NISHIDA, Yasuo ONO
  • Publication number: 20220087524
    Abstract: An eye movement analysis system includes an image-capturing unit configured to capture a moving image including at least one of a right eye and a left eye of a subject and a comparison target on a surface of a face of the subject, and an analysis unit configured to analyze a movement of an eyeball of the at least one of the right eye and the left eye of the subject, based on a relationship between the at least one of the right eye and the left eye of the subject and the comparison target on the moving image captured by the image-capturing unit.
    Type: Application
    Filed: March 2, 2020
    Publication date: March 24, 2022
    Applicant: TEIKYO UNIVERSITY
    Inventors: Kakeru SASAKI, Takao HAYASHI
  • Publication number: 20220072109
    Abstract: The present invention provides a method for treating or preventing inflammation caused by neutrophils and a pharmaceutical composition for such treatment or prevention. Specifically, provided is a pharmaceutical composition or the like for treating or preventing inflammation caused by neutrophils that contains a complex in which lysozyme and chitosan are bonded.
    Type: Application
    Filed: January 14, 2020
    Publication date: March 10, 2022
    Applicants: WAKO FILTER TECHNOLOGY CO., LTD., TEIKYO UNIVERSITY
    Inventors: Hiroki KAGESHIMA, Yoichi MURAKAMI, Akira SAITO, Shigeru ABE, Kazumi HAYAMA, Naho MARUYAMA
  • Publication number: 20220038053
    Abstract: A method for estimating an operation voltage of a cell includes setting a state in which one cell is shielded from light; detecting a small change of an output current of a module in that state; irradiating another cell with modulated and detecting the small change of the output current light in that state; detecting an operation voltage of the module in that state; generating a first calibration line by connecting a first point and a second point which are plotted on coordinate axes representing a voltage and a relative ratio of a resistor; irradiating a cell the operation voltage of which is to be estimated with the modulated light and detecting the small change of the output current of the module in a state in which none of the cells is shielded from light; detecting the operation voltage of the module in that state; generating a second calibration line by connecting a third point and the second point which are plotted on the coordinate axes; calculating a value of the relative ratio of the resistor of the
    Type: Application
    Filed: December 11, 2019
    Publication date: February 3, 2022
    Applicant: TEIKYO UNIVERSITY
    Inventors: Yasuyuki KOBAYASHI, Shunsuke KISU
  • Publication number: 20210261964
    Abstract: An object is to provide a technology that can stably exhibit the effects of A-type CpG oligodeoxynucleotides. The object can be achieved by a lipid particle comprising an A-type CpG oligodeoxynucleotide.
    Type: Application
    Filed: July 18, 2019
    Publication date: August 26, 2021
    Applicants: THE RESEARCH FOUNDATION FOR MICROBIAL DISEASES OF OSAKA UNIVERSITY, OSAKA UNIVERSITY, TEIKYO UNIVERSITY
    Inventors: Taiki AOSHI, Shohei KOYAMA, Ryo SUZUKI
  • Publication number: 20210201508
    Abstract: Even for the case where cells such as human epidermal keratinocytes form a dense colony, or the case where cell contours are indefinite, each of the cells is automatically tracked with high precision, and behavior of each cell is analyzed with good precision. There is provided a method for analyzing behavior of a cell, which comprises a detection step of detecting positions of a plurality of cells for every frame of time-lapse images, while determining whether a candidate region extracted from the frame is a cell region by using a dictionary containing image data of cell nuclei; and a tracking step of tracking each cell by using a state space model using position of a most adjacent cell within a predetermined distance from a predicted position as observation data. When any cell is not found within a certain distance from the predicted position, data are considered missing.
    Type: Application
    Filed: June 19, 2019
    Publication date: July 1, 2021
    Applicant: TEIKYO UNIVERSITY
    Inventors: Junichi Kotoku, Takuya Hirose, Daisuke Nanba, Emi Nishimura
  • Publication number: 20210164058
    Abstract: A method for detecting Candida auris, including subjecting a nucleic acid sample obtained from a specimen to a nucleic acid amplification reaction by the LAMP method and detecting an amplification product, wherein, in the primer set to be used in the LAMP method, FIP is a polynucleotide including 5 to 20 nucleotides located on the 5?-terminal side and 5 to 20 nucleotides located on the 3?-terminal side in the nucleotide sequence represented by SEQ ID NO: 1, BIP is a polynucleotide including 5 to 20 nucleotides located on the 5?-terminal side and 5 to 20 nucleotides located on the 3?-terminal side in the nucleotide sequence represented by SEQ ID NO: 2, F3 is a polynucleotide including SEQ ID NO: 3, and B3 is a polynucleotide including SEQ ID NO: 4.
    Type: Application
    Filed: April 25, 2019
    Publication date: June 3, 2021
    Applicant: TEIKYO UNIVERSITY
    Inventors: Koichi MAKIMURA, Mikachi YAMAMOTO, Mahdi Alshahni MOHAMED
  • Publication number: 20200385820
    Abstract: The present invention has an object to provide a simpler and quicker method for diagnosing tinea, method for detecting a Trichophyton, or method for detecting the Trichophyton gene. Use of at least four kinds of specific primers each designed based on a DNA sequence of the Trichophyton gene makes it possible to simply and quickly detect the Trichophyton gene.
    Type: Application
    Filed: February 15, 2019
    Publication date: December 10, 2020
    Applicants: SATO PHARMACEUTICAL CO., LTD., TEIKYO UNIVERSITY
    Inventors: Koichi MAKIMURA, Kazuo SATOH, Yoshiharu MIYAJIMA
  • Patent number: 10688199
    Abstract: Provided is a theranostic bubble preparation which makes it possible to diagnose and treat a tissue of interest by the irradiation with ultrasound such as diagnostic ultrasound and low-intensity therapeutic ultrasound. The theranostic bubble preparation comprises: a coating film comprising a lipid; and a gas enclosed in an inner cavity formed in the coating film. The coating film comprises an anionic lipid made from distearoylphosphatidylcholine (DSPC), distearoylphosphatidylglycerol (DSPG) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG2000). The gas and the mixed gas comprises perfluoropropane or perfluorobutane.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: June 23, 2020
    Assignee: TEIKYO UNIVERSITY
    Inventors: Kazuo Maruyama, Ryo Suzuki, Johan Mikael Unga, Daiki Omata, Yusuke Oda