Patents Assigned to TEIKYO UNIVERSITY
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Patent number: 12207875Abstract: An eye movement analysis system includes an image-capturing unit configured to capture a moving image including at least one of a right eye and a left eye of a subject and a comparison target on a surface of a face of the subject, and an analysis unit configured to analyze a movement of an eyeball of the at least one of the right eye and the left eye of the subject, based on a relationship between the at least one of the right eye and the left eye of the subject and the comparison target on the moving image captured by the image-capturing unit.Type: GrantFiled: March 2, 2020Date of Patent: January 28, 2025Assignee: TEIKYO UNIVERSITYInventors: Kakeru Sasaki, Takao Hayashi
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Patent number: 12178859Abstract: The present invention provides a method for treating or preventing inflammation caused by neutrophils and a pharmaceutical composition for such treatment or prevention. Specifically, provided is a pharmaceutical composition or the like for treating or preventing inflammation caused by neutrophils that contains a complex in which lysozyme and chitosan are bonded.Type: GrantFiled: January 14, 2020Date of Patent: December 31, 2024Assignees: WAKO FILTER TECHNOLOGY CO., LTD., TEIKYO UNIVERSITYInventors: Hiroki Kageshima, Yoichi Murakami, Akira Saito, Shigeru Abe, Kazumi Hayama, Naho Maruyama
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Publication number: 20240411119Abstract: An intraocular illumination device includes a fiber that guides light from a light source, and a holder that is disposed between an objective lens of a microscope and an eye during eye surgery or examination and supports a tip portion of the fiber. The tip portion of the fiber is provided with a reflecting portion that reflects the light guided through the fiber toward an inside of the eye.Type: ApplicationFiled: October 21, 2022Publication date: December 12, 2024Applicants: UNIVERSITY OF TSUKUBA, TEIKYO UNIVERSITYInventors: Shohei MORIKAWA, Toshifumi MIHASHI
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Patent number: 11932595Abstract: Provided are vitamin D3 derivatives of formula (I), pharmaceutical compositions thereof, and pharmaceutical or medical uses thereof for treating metabolic disease, a liver disease, obesity, diabetes, cardiovascular disease, or cancer in a patient in need thereof.Type: GrantFiled: September 17, 2021Date of Patent: March 19, 2024Assignee: KYOTO UNIVERSITY, NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY, TEIKYO UNIVERSITY and THE UNIVERSITY OF TOKYOInventors: Motonari Uesugi, Yasushi Takemoto, Kazuo Nagasawa, Atsushi Kittaka, Fumihiro Kawagoe, Hayato Nakagawa
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Patent number: 11936338Abstract: A method for estimating an operation voltage of a cell includes setting a state in which one cell is shielded from light; detecting a small change of an output current of a module in that state; irradiating another cell with modulated and detecting the small change of the output current light in that state; detecting an operation voltage of the module in that state; generating a first calibration line by connecting a first point and a second point which are plotted on coordinate axes representing a voltage and a relative ratio of a resistor; irradiating a cell the operation voltage of which is to be estimated with the modulated light and detecting the small change of the output current of the module in a state in which none of the cells is shielded from light; detecting the operation voltage of the module in that state; generating a second calibration line by connecting a third point and the second point which are plotted on the coordinate axes; calculating a value of the relative ratio of the resistor of theType: GrantFiled: December 11, 2019Date of Patent: March 19, 2024Assignee: TEIKYO UNIVERSITYInventors: Yasuyuki Kobayashi, Shunsuke Kisu
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Patent number: 11753689Abstract: A method for detecting Candida auris, including subjecting a nucleic acid sample obtained from a specimen to a nucleic acid amplification reaction by the LAMP method and detecting an amplification product, wherein, in the primer set to be used in the LAMP method, FIP is a polynucleotide including 5 to 20 nucleotides located on the 5?-terminal side and 5 to 20 nucleotides located on the 3?-terminal side in the nucleotide sequence represented by SEQ ID NO: 1, BIP is a polynucleotide including 5 to 20 nucleotides located on the 5?-terminal side and 5 to 20 nucleotides located on the 3?-terminal side in the nucleotide sequence represented by SEQ ID NO: 2, F3 is a polynucleotide including SEQ ID NO: 3, and B3 is a polynucleotide including SEQ ID NO: 4.Type: GrantFiled: April 25, 2019Date of Patent: September 12, 2023Assignee: TEIKYO UNIVERSITYInventors: Koichi Makimura, Mikachi Yamamoto, Mohamed Mahdi Alshahni
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Publication number: 20230272388Abstract: Provided a novel miR-96-5p inhibitor that is more effective than an antisense oligonucleotide against miR-96-5p, and a novel pharmaceutical composition comprising the same. The miR-96-5p inhibitor comprises a peptide nucleic acid moiety comprising a nucleotide sequence complementary to miR-96-5p.Type: ApplicationFiled: July 29, 2021Publication date: August 31, 2023Applicant: TEIKYO UNIVERSITYInventors: Toshio NAKAKI, Koji AOYAMA, Chisato KINOSHITA, Nobuko MATSUMURA, Kazue UTSUMI, Toru SUGIYAMA, Shun-suke MORIYA
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Publication number: 20230077422Abstract: According to an embodiment, there are provided a screening culture medium that enables a convenient and quick examination for the presence of Candida auris, and a screening method. According to at least one embodiment, the screening culture medium contains an enzyme substrate, in which the screening culture medium is used for screening Candida auris based on an ability to degrade the enzyme substrate, the enzyme substrate including raffinose and xylose. According to another embodiment, the screening method uses the screening culture medium.Type: ApplicationFiled: February 1, 2021Publication date: March 16, 2023Applicant: TEIKYO UNIVERSITYInventors: Koichi MAKIMURA, Takashi TAMURA
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Patent number: 11560602Abstract: The present invention has an object to provide a simpler and quicker method for diagnosing tinea, method for detecting a Trichophyton, or method for detecting the Trichophyton gene. Use of at least four kinds of specific primers each designed based on a DNA sequence of the Trichophyton gene makes it possible to simply and quickly detect the Trichophyton gene.Type: GrantFiled: February 15, 2019Date of Patent: January 24, 2023Assignees: SATO PHARMACEUTICAL CO., LTD., TEIKYO UNIVERSITYInventors: Koichi Makimura, Kazuo Satoh, Yoshiharu Miyajima
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Patent number: 11475578Abstract: Even for the case where cells such as human epidermal keratinocytes form a dense colony, or the case where cell contours are indefinite, each of the cells is automatically tracked with high precision, and behavior of each cell is analyzed with good precision. There is provided a method for analyzing behavior of a cell, which comprises a detection step of detecting positions of a plurality of cells for every frame of time-lapse images, while determining whether a candidate region extracted from the frame is a cell region by using a dictionary containing image data of cell nuclei; and a tracking step of tracking each cell by using a state space model using position of a most adjacent cell within a predetermined distance from a predicted position as observation data. When any cell is not found within a certain distance from the predicted position, data are considered missing.Type: GrantFiled: June 19, 2019Date of Patent: October 18, 2022Assignee: TEIKYO UNIVERSITYInventors: Junichi Kotoku, Takuya Hirose, Daisuke Nanba, Emi Nishimura
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Patent number: 11464403Abstract: A tracheal tube insertion aid kit (1) assists in inserting a tracheal tube (9) from an oral cavity (B) of a patient (A) into an endotracheal space (E) through a glottis (D) using an indirect glottis viewing type laryngoscope (2) not equipped with the tracheal tube (9). The tracheal tube insertion aid kit (1) includes a guide tube (11) having flexibility and formed to be insertable into the endotracheal space (E) from the oral cavity (B) through the glottis (D), and a guide wire (12) formed to be insertable through the inside of the guide tube (11) and insertable into the endotracheal space (E) from the oral cavity (B) through the glottis (D).Type: GrantFiled: November 22, 2017Date of Patent: October 11, 2022Assignee: TEIKYO UNIVERSITYInventor: Yoshiki Hara
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Publication number: 20220098646Abstract: A detection method for pan-resistant K. pneumoniae comprising of: performing complete genome analysis of the bacteria contained in the sample; and comparing a nucleotide sequence contained in the obtained complete genome with nucleotide sequences of SEQ ID NO: 1 or 2, and determining whether or not the bacteria in the sample is pan-resistant K. pneumoniae based on the rate of agreement.Type: ApplicationFiled: November 15, 2019Publication date: March 31, 2022Applicant: TEIKYO UNIVERSITYInventors: Satoshi NISHIDA, Yasuo ONO
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Publication number: 20220087524Abstract: An eye movement analysis system includes an image-capturing unit configured to capture a moving image including at least one of a right eye and a left eye of a subject and a comparison target on a surface of a face of the subject, and an analysis unit configured to analyze a movement of an eyeball of the at least one of the right eye and the left eye of the subject, based on a relationship between the at least one of the right eye and the left eye of the subject and the comparison target on the moving image captured by the image-capturing unit.Type: ApplicationFiled: March 2, 2020Publication date: March 24, 2022Applicant: TEIKYO UNIVERSITYInventors: Kakeru SASAKI, Takao HAYASHI
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Publication number: 20220072109Abstract: The present invention provides a method for treating or preventing inflammation caused by neutrophils and a pharmaceutical composition for such treatment or prevention. Specifically, provided is a pharmaceutical composition or the like for treating or preventing inflammation caused by neutrophils that contains a complex in which lysozyme and chitosan are bonded.Type: ApplicationFiled: January 14, 2020Publication date: March 10, 2022Applicants: WAKO FILTER TECHNOLOGY CO., LTD., TEIKYO UNIVERSITYInventors: Hiroki KAGESHIMA, Yoichi MURAKAMI, Akira SAITO, Shigeru ABE, Kazumi HAYAMA, Naho MARUYAMA
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Publication number: 20220038053Abstract: A method for estimating an operation voltage of a cell includes setting a state in which one cell is shielded from light; detecting a small change of an output current of a module in that state; irradiating another cell with modulated and detecting the small change of the output current light in that state; detecting an operation voltage of the module in that state; generating a first calibration line by connecting a first point and a second point which are plotted on coordinate axes representing a voltage and a relative ratio of a resistor; irradiating a cell the operation voltage of which is to be estimated with the modulated light and detecting the small change of the output current of the module in a state in which none of the cells is shielded from light; detecting the operation voltage of the module in that state; generating a second calibration line by connecting a third point and the second point which are plotted on the coordinate axes; calculating a value of the relative ratio of the resistor of theType: ApplicationFiled: December 11, 2019Publication date: February 3, 2022Applicant: TEIKYO UNIVERSITYInventors: Yasuyuki KOBAYASHI, Shunsuke KISU
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Publication number: 20210261964Abstract: An object is to provide a technology that can stably exhibit the effects of A-type CpG oligodeoxynucleotides. The object can be achieved by a lipid particle comprising an A-type CpG oligodeoxynucleotide.Type: ApplicationFiled: July 18, 2019Publication date: August 26, 2021Applicants: THE RESEARCH FOUNDATION FOR MICROBIAL DISEASES OF OSAKA UNIVERSITY, OSAKA UNIVERSITY, TEIKYO UNIVERSITYInventors: Taiki AOSHI, Shohei KOYAMA, Ryo SUZUKI
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Publication number: 20210201508Abstract: Even for the case where cells such as human epidermal keratinocytes form a dense colony, or the case where cell contours are indefinite, each of the cells is automatically tracked with high precision, and behavior of each cell is analyzed with good precision. There is provided a method for analyzing behavior of a cell, which comprises a detection step of detecting positions of a plurality of cells for every frame of time-lapse images, while determining whether a candidate region extracted from the frame is a cell region by using a dictionary containing image data of cell nuclei; and a tracking step of tracking each cell by using a state space model using position of a most adjacent cell within a predetermined distance from a predicted position as observation data. When any cell is not found within a certain distance from the predicted position, data are considered missing.Type: ApplicationFiled: June 19, 2019Publication date: July 1, 2021Applicant: TEIKYO UNIVERSITYInventors: Junichi Kotoku, Takuya Hirose, Daisuke Nanba, Emi Nishimura
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Publication number: 20210164058Abstract: A method for detecting Candida auris, including subjecting a nucleic acid sample obtained from a specimen to a nucleic acid amplification reaction by the LAMP method and detecting an amplification product, wherein, in the primer set to be used in the LAMP method, FIP is a polynucleotide including 5 to 20 nucleotides located on the 5?-terminal side and 5 to 20 nucleotides located on the 3?-terminal side in the nucleotide sequence represented by SEQ ID NO: 1, BIP is a polynucleotide including 5 to 20 nucleotides located on the 5?-terminal side and 5 to 20 nucleotides located on the 3?-terminal side in the nucleotide sequence represented by SEQ ID NO: 2, F3 is a polynucleotide including SEQ ID NO: 3, and B3 is a polynucleotide including SEQ ID NO: 4.Type: ApplicationFiled: April 25, 2019Publication date: June 3, 2021Applicant: TEIKYO UNIVERSITYInventors: Koichi MAKIMURA, Mikachi YAMAMOTO, Mahdi Alshahni MOHAMED
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Publication number: 20200385820Abstract: The present invention has an object to provide a simpler and quicker method for diagnosing tinea, method for detecting a Trichophyton, or method for detecting the Trichophyton gene. Use of at least four kinds of specific primers each designed based on a DNA sequence of the Trichophyton gene makes it possible to simply and quickly detect the Trichophyton gene.Type: ApplicationFiled: February 15, 2019Publication date: December 10, 2020Applicants: SATO PHARMACEUTICAL CO., LTD., TEIKYO UNIVERSITYInventors: Koichi MAKIMURA, Kazuo SATOH, Yoshiharu MIYAJIMA
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Patent number: 10688199Abstract: Provided is a theranostic bubble preparation which makes it possible to diagnose and treat a tissue of interest by the irradiation with ultrasound such as diagnostic ultrasound and low-intensity therapeutic ultrasound. The theranostic bubble preparation comprises: a coating film comprising a lipid; and a gas enclosed in an inner cavity formed in the coating film. The coating film comprises an anionic lipid made from distearoylphosphatidylcholine (DSPC), distearoylphosphatidylglycerol (DSPG) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG2000). The gas and the mixed gas comprises perfluoropropane or perfluorobutane.Type: GrantFiled: June 10, 2016Date of Patent: June 23, 2020Assignee: TEIKYO UNIVERSITYInventors: Kazuo Maruyama, Ryo Suzuki, Johan Mikael Unga, Daiki Omata, Yusuke Oda