Abstract: A reconstruction system is presented for reconstructing morphology of biological cells. The system includes data input and output utilities, memory, and a data processor, and is configured for data communication with an image data provider to receive raw image data comprising a sequence of image frames acquired from the cell during a movement of the cell and being indicative of optical path delay (OPD) of light propagation through the biological cell. The data processor is configured and operable to process the raw image data and determine 3D dynamic morphological data of the cell. The data processor includes: a modeling utility; a position recovery module; and an analyzer module.

Abstract: Provided herein is a see-through transparent, stable, safe and (bio)degradable hydrogel-based particulate support medium, made of calcium alginate particles. The calcium alginate particles, or hybrid hydrogel particles, are characterized by a substantially homogeneous average particle size that ranges from 0.1 micrometer to 5 micrometer.

Abstract: Structures for response shaping in frequency and time domain, include an optical response shaper and/or a modulator device with multiple injection. The device comprises a resonator having an enclosed geometric structure, for example a ring or racetrack structure, at least two injecting optical waveguides approaching the resonator to define at least two coupling regions between the resonator and the injecting waveguides, and may define at least two Free Spectral Range states. One or both of the coupling regions has a coupling coefficient selected for a predetermined frequency or time response, and the coupling coefficient or other device parameters may be variable, in some case in real time to render the response programmably variable. In addition, the injection power at one of the optical waveguides serves to modify the response.

Abstract: A system for monitoring at least presence of a bioanalyte. The system comprises: a substrate having a skin contact surface, a microneedle outwardly protruding from the skin contact surface, a sensing complex positioned in the microneedle, and a circuit attached to the substrate. The sensing complex can comprise a nanostructure modified by a functional moiety covalently attached thereto, and an affinity moiety effective to react specifically with the bioanalyte to produce a reaction product. The circuit can apply voltage to the nanostructure and monitor changes in an electrical property of the nanostructure responsively to reaction between the reaction product and the functional moiety.

Abstract: A method of treating an inflammatory disease or disorder of the central nervous system (CNS) in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of an agent capable of binding CD157 on CD157-expressing cells of the CNS, the agent capable of mediating a therapeutic effect.

Abstract: A method of treating brain-metastasized cancer in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent that specifically decreases an amount and/or activity of P-selectin and an immunomodulatory agent. Methods of treating additional cancers are also disclosed.

Abstract: In a system for converting digital data into a modulated optical signal, an electrically controllable device, including a modulator having one or more actuating electrodes, provides an analog-modulated optical signal that is modulated in response to output data bits of a digital-to-digital mapping. A digital-to-digital conversion provides the mapping of input data words to the output data bits. The mapping enables adjustments to correct for non-linearities and other undesirable characteristics, thereby improving signal quality.

Abstract: A piezoelectric transducer is provided herein, comprising a three-dimensional structure made of a plurality of peptides, the peptides being self-assembling and the structure being piezoelectric, wherein at least a portion, or each, of said plurality of peptides comprises peptides of 2 to 10 amino acid residues, provided that the plurality of peptides is not consisted of a plurality of Phe-Phe dipeptides. Further described herein are peptides having an amino acid sequence Hyp-Phe-Phe, Boc-Dip-Dip, (L)Trp-(D)Trp or (D)Trp-(L)Trp, as well as three-dimensional structures comprising such peptides.

Abstract: In a system for converting digital data into a modulated optical signal, an electrically controllable device, including a modulator having one or more actuating electrodes, provides an analog-modulated optical signal that is modulated in response to output data bits of a digital-to-digital mapping. A digital-to-digital conversion provides the mapping of input data words to the output data bits.

Abstract: Bioink compositions comprising a plurality of aromatic peptides and a matrix-forming material, formulations and kits for preparing same, additive manufacturing (bioprinting) processes utilizing same and three-dimensional objects obtained thereby are provided.

Abstract: The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which are capable of detecting or imaging, more specifically, determining the presence, or measuring the level, of proteases, as well as compositions and uses thereof.

Abstract: A dynamic vision sensor (DVS) color camera (DVS-CCam) operable to acquire a color image of a scene, the DVS-CCam including a DVS photosensor comprising DVS pixels, an illuminator operable to transmit a light pattern characterized by temporal changes in intensity and color to illuminate a scene, an optical system configured to collect and focus on the pixels of the DVS photosensor light reflected by features in the scene from the light pattern transmitted by the illuminator, and a processor configured to process DVS signals generated by the DVS pixels responsive to temporal changes in the reflected light to provide a color image of the scene.

Abstract: A method of treating a cancer which is characterized by an up-regulation of expression of lysyl oxidase (LOX) and heat shock protein 70 (HSP70) is disclosed. The method comprises administering to the subject a therapeutically effective amount of a polypeptide comprising a propeptide of lysyl oxidase (LOX), said polypeptide being devoid of LOX catalytic activity, wherein said polypeptide binds to both LOX and heat shock protein 70 (HSP70) with a EC50 of less than 100 nM.

Abstract: Compounds capable of interacting with the calmodulin-PIP2 binding domain of the SK4 channel to thereby interfere with the Ca2+-dependent activation of the SK4 channel and uses thereof in downregulating an activity of an SK4 channel in a subject in need thereof, are disclosed. Also disclosed is a method of identifying a candidate compound that is capable of downregulating an activity of SK4 channel, based on its interaction with the calmodulin-PIP2 binding domain of the SK4 channel.

Abstract: A method of designing a nanostructure, comprises: receiving a far field optical response and material properties; feeding the synthetic far field optical response and material properties to an artificial neural network having at least three hidden layers; and extracting from the artificial neural network a shape of a nanostructure corresponding to the far field optical response.

Abstract: Methods and compositions employing hybrid hydrogels formed of high molecular weight hyaluronic acid and a plurality of self-assembled peptides in inducing bone regeneration are provided.

Abstract: A functionalized electrode capable of selectively interacting with a viral biomarker, an electrochemical system comprising the electrode and methods utilizing same for, for example, determining a presence of a viral infection in a subject are provided.

Abstract: The invention relates to systems, methods, network devices, and machine-readable media for encoding an input message with robustness against noise by executing a compressing hash function on the input message, encoding an output of the hash function and the input message to generate a single combined message, executing a permutation function on the combined message, and encoding the result of the permutation function with a list-decodable code.

Abstract: Hybrid hydrogels, made of a three-dimensional network of fibrillar nanostructures, at least a portion of the fibrillar nanostructures being formed of at least two different types of aromatic moieties, at least one type of the aromatic moieties being an end-capping modified aromatic dipeptide and at least another type of the aromatic moieties being an amine-modified halogenated aromatic amino acid, are provided. Also provided are processes of preparing the hybrid hydrogels and uses thereof.

Abstract: A composition is disclosed which comprises a plurality of fibrous particles fabricated from decellularized omentum, the fibrous particles being between 750 microns-3 mm in diameter, wherein the fibrous particles comprise a network of mature neurons. Uses thereof and methods of generating same are also disclosed.