Patents Assigned to Tel Hashomer Medical Research Infrastructure and Services Ltd.
  • Patent number: 11911018
    Abstract: Apparatus for performing an ocular surgery, the apparatus comprising: a support housing having a bottom configured to be positioned on the sclera of an eye during performance of an ocular surgery; a muscle hook holder connected to the support housing and configured to hold an ocular muscle hook so that the ocular muscle hook is translatable to elevate an ocular muscle away from the eye during performance of the surgery; and a set of graduation markings on the support housing useable to determine a distance that the ocular muscle hook is translated to elevate the ocular muscle.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: February 27, 2024
    Assignee: TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Ari Leshno
  • Patent number: 11911138
    Abstract: Disclosed are methods and devices useful for imaging blood-containing tissue, for example for angiography, especially retinal angiography, whereby an image is generated by dividing pixels of an image acquired at some wavelength range by corresponding pixels of an image acquired at a different wavelength range. In some embodiments, a first wavelength range includes predominantly light having wavelengths between about 400 nm and about 620 nm and a second wavelength range includes predominantly light having wavelengths between about 620 nm and about 800 nm.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: February 27, 2024
    Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramot At Tel AvivUniversity Ltd.
    Inventors: Genady Kostenich, Arie Orenstein, Michael Belkin
  • Publication number: 20240041902
    Abstract: Compositions capable of reducing viability, initiating apoptosis, inducing cell cycle arrest and/or reducing migration of urothelial carcinoma cells and methods of use thereof are provided. The compositions and uses thereof comprise cannabinoids.
    Type: Application
    Filed: December 8, 2021
    Publication date: February 8, 2024
    Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization, Tel HaShomer Medical Research Infrastructure and Services Ltd.
    Inventors: Hinanit KOLTAI, Omer ANIS
  • Patent number: 11892530
    Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.
    Type: Grant
    Filed: August 13, 2020
    Date of Patent: February 6, 2024
    Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.
    Inventors: Yael Mardor, Leor Zach, David Guez, David Last, Dianne Daniels Elmakias
  • Patent number: 11827687
    Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.
    Type: Grant
    Filed: February 3, 2022
    Date of Patent: November 28, 2023
    Assignee: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventors: Genady Kostenich, Mor Oron-Herman, Arie Orenstein, Talia Shekhter Zahavi, Ehud Gazit, Yoseph Salitra, Ludmilla Buzhansky
  • Patent number: 11820833
    Abstract: An isolated peptide of up to 6 amino acids comprising an amino acid sequence which inhibits binding of an endothelial cell protein C receptor (EPCR) ligand to the EPCR is disclosed. Also disclosed is an isolated peptide comprising an amino acid sequence which inhibits binding of an endothelial cell protein C receptor (EPCR) ligand to the EPCR, wherein the peptide comprises a modification in at least one amino acid. Also disclosed is a molecule comprising an amino acid sequence which inhibits binding of an endothelial cell protein C receptor (EPCR) ligand to the EPCR attached to a heterologous moiety. Pharmaceutical compositions and methods of treatment are also disclosed.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: November 21, 2023
    Assignee: Tel HaShomer Medical Research infrastructure and Services Ltd.
    Inventors: Nicola Maggio, Joab Chapman, Efrat Shavit Stein
  • Publication number: 20230355727
    Abstract: Ophthalmic formulations comprising a PAR1 antagonist and/or an agent that interferes with an interaction of PAR1 and a protease (e.g., thrombin), and an ophthalmically acceptable carrier, and uses thereof in treating or preventing retinal pathologies such as retinal degeneration, are provided. The agent can be, for example, a peptide conjugate represented by Formula I, as defined in the specification.
    Type: Application
    Filed: May 9, 2023
    Publication date: November 9, 2023
    Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.
    Inventors: Joab CHAPMAN, Efrat SHAVIT STEIN, Ygal ROTENSTREICH, Ifat SHER ROSENTHAL
  • Publication number: 20230360220
    Abstract: A method of diagnosing a condition of a subject, comprises: receiving image data of an anterior of an eye of the subject, and analyzing the image data to detect at least one of: flow of individual blood cells in libmal or conjunctival blood vessels of the eye, morphology of limbal or conjunctival blood vessels. The method also comprises determining the condition of the subject based on the detection(s).
    Type: Application
    Filed: July 18, 2023
    Publication date: November 9, 2023
    Applicants: Ramot at Tel-Aviv University Ltd., Tel HaShomer Medical Research Infrastructure and Services Ltd.
    Inventors: Ygal ROTENSTREICH, Ifat SHER ROSENTHAL, Haim SUCHOWSKI, Michael MREJEN, Shahar KATZ
  • Publication number: 20230329723
    Abstract: A device for retarding birth including an upper ring for surrounding a cervix, an anchoring component for anchoring the device, and an elastic component for attaching the upper ring to the anchoring component, wherein the elastic component pushes the upper ring and the anchoring component apart. A device for retarding birth including a sleeve for surrounding a cervix along a greater portion of a length of the cervix, a support strip on the sleeve directed along an axis of the sleeve, and a ring at least partially around the sleeve, in which when a top of the sleeve is pushed to expand radially, the support strip pivots on the ring, such that an end of the support strip near the top of the sleeve moves radially outward, and an end of the support strip near the bottom of the sleeve moves radially inward. Related apparatus and methods are also described.
    Type: Application
    Filed: June 22, 2023
    Publication date: October 19, 2023
    Applicants: Tel HaShomer Medical Research Infrastructure and Services Ltd., The Trendlines Group Ltd.
    Inventors: Abraham TSUR, Sharon FARBER, Roy MASHIACH, Yosef HAZAN, David SHASHAR, Avshalom SHENHAV
  • Patent number: 11771596
    Abstract: Apparatus for medical treatment includes a laser source, which is configured to output a beam of laser radiation. An optical device is configured to direct the laser radiation to impinge on a limbal area of an eye with optical properties chosen so as to apply a desired treatment to a tissue structure associated with a cornea of the eye within the limbal area.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: October 3, 2023
    Assignees: RAMOT AT TEL-AVIV UNIVERSITY LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventors: Michael Belkin, Mordechai Goldenfeld
  • Publication number: 20230287512
    Abstract: Methods of determining suitability of a subject to be treated with a PD-1/PD-L1 based immunotherapy, comprising receiving a sample from the subject and determining HVEM levels in the sample, wherein expression of HVEM above a predetermined threshold indicates the subject is suitable to be treated by the immunotherapy or of determining suitability of a subject non-responsive to a PD-1/PD-L1 based immunotherapy to be treated by an HVEM based immunotherapy, comprising receiving a sample from the subject and determining T cell levels in the sample, wherein T cell levels above a predetermined threshold indicates the subject is suitable to be treated by the HVEM based immunotherapy are provided.
    Type: Application
    Filed: April 4, 2023
    Publication date: September 14, 2023
    Applicants: 4C BIOMED LIMITED, TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventors: Eyal GREENBERG, Gilli GALORE-HASKEL, Efrat MERHAVI-SHOHAM, Gal MARKEL
  • Publication number: 20230273211
    Abstract: A method of diagnosing breast cancer is disclosed. The method comprises lysing extracellular vesicles of a subject to generate a composition comprising components of extracellular vesicles; measuring the amount of MEK1 in the composition; and diagnosing the subject with breast cancer when a level of said MEK1 in said composition is above a predetermined threshold. Kits for breast cancer diagnosis are also disclosed.
    Type: Application
    Filed: March 30, 2023
    Publication date: August 31, 2023
    Applicants: Yeda Research and Development Co. Ltd., Tel HaShomer Medical Research Infrastructure and Services Ltd.
    Inventors: Sima LEV, Yaron VINIK, Francisco Gabriel ORTEGA, Mordechai GUTMAN MD
  • Publication number: 20230263661
    Abstract: The present invention enables assisting in manipulation and movement of intraocular particles in order to treat various ocular conditions. It enables controlling intra-ocular particles using acoustic wave forces. The novel technique of the present invention utilizes acoustic radiation forces for non-invasive control over movement of the pathologic intraocular particles, preventing them from unwanted accumulation and obstruction of intraocular structures, or causing visual disturbances. Acoustic forces can be harnessed to non-invasively organize various types of endogenous and exogenous particles within the anterior chamber of the eye, without any sign of tissue damage.
    Type: Application
    Filed: July 14, 2021
    Publication date: August 24, 2023
    Applicants: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD., BAR ILAN UNIVERSITY
    Inventors: Alon Skaat, Ari Leshno, Avraham Kenigsberg, Hagay Shpaisman
  • Patent number: 11730436
    Abstract: A method of processing a given region of interest (ROI) of an X-ray image of a person's breast to determine presence of a malignancy, the X-ray image having X-ray pixels that indicate intensity of X-rays that passed through the breast to generate the image, the method comprising: for each given X-ray pixel in the given ROI and each of a selection of J(r) X-ray pixels at respective pixel radii PR(r), 1?r?R, from the given x-ray pixel, determining a binary number that provides a measure X-ray intensity indicated by the selected X-ray pixel relative to X-ray intensity indicated by the given X-ray pixel; using the determined binary numbers for the selected X-ray pixels at each pixel radius PR(r) to determine a decimal number for the pixel radius PR(r); histogramming the frequency of occurrence of values of the determined decimal numbers as a function of pixel radius for the given X-ray pixels in the given ROI; determining a texture feature vector, for the given ROI having components that are equal to the frequenc
    Type: Grant
    Filed: December 25, 2022
    Date of Patent: August 22, 2023
    Assignee: Tel HaShomer Medical Research, Infrastructure and Services Ltd.
    Inventors: Miriam Sklair-Levy, Arnaldo Mayer, Shmuel Yitzhak Pfeffer
  • Patent number: 11712248
    Abstract: A device for retarding birth including an upper ring for surrounding a cervix, an anchoring component for anchoring the device, and an elastic component for attaching the upper ring to the anchoring component, wherein the elastic component pushes the upper ring and the anchoring component apart. A device for retarding birth including a sleeve for surrounding a cervix along a greater portion of a length of the cervix, a support strip on the sleeve directed along an axis of the sleeve, and a ring at least partially around the sleeve, in which when a top of the sleeve is pushed to expand radially, the support strip pivots on the ring, such that an end of the support strip near the top of the sleeve moves radially outward, and an end of the support strip near the bottom of the sleeve moves radially inward. Related apparatus and methods are also described.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: August 1, 2023
    Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., The Trendlines Group Ltd.
    Inventors: Abraham Tsur, Sharon Farber, Roy Mashiach, Yosef Hazan, David Shashar, Avshalom Shenhav
  • Publication number: 20230226293
    Abstract: A system for providing treatment adapted to clear lung airways, the system including at least one pressure applicator adapted, when activated, to apply pressure at at least one specific location on a torso of a patient, and, when deactivated, to release the pressure, a sensor for sensing a signal associated with the patient, and, a controller, in communication with the sensor, adapted to analyze the signal and to control activation and deactivation of the at least one pressure applicator based, at least in part, on analyzing the signal. Related apparatus and methods are also described.
    Type: Application
    Filed: April 22, 2021
    Publication date: July 20, 2023
    Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.
    Inventors: Moshe ASHKENAZI, Gil SOKOL, Ori EFRATI
  • Patent number: 11699236
    Abstract: There is provided a computer implemented method of automatic segmentation of three dimensional (3D) anatomical region of interest(s) (ROI) that includes predefined anatomical structure(s) of a target individual, comprising: receiving 3D images of a target individual, each including the predefined anatomical structure(s), each 3D image is based on a different respective imaging modality. In one implementation, each respective 3D image is inputted into a respective processing component of a multi-modal neural network, wherein each processing component independently computes a respective intermediate, and the intermediate outputs are inputted into a common last convolutional layer(s) for computing the indication of segmented 3D ROI(s). In another implementation, each respective 3D image is inputted into a respective encoding-contracting component a multi-modal neural network, wherein each encoding-contracting component independently computes a respective intermediate output.
    Type: Grant
    Filed: September 28, 2021
    Date of Patent: July 11, 2023
    Assignees: Ramot at Tel-Aviv University Ltd., Tel HaShomer Medical Research Infrastructure and Services Ltd.
    Inventors: Yitzhak Avital, Nahum Kiryati, Eli Konen, Arnaldo Mayer
  • Publication number: 20230190887
    Abstract: Testing peptides in in vitro models of neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, Frontotemporal dementia, Amyotrophic lateral sclerosis, to evaluate systems and methods of treatment therefore.
    Type: Application
    Filed: November 18, 2022
    Publication date: June 22, 2023
    Applicants: University of South Carolina, Ramot at Tel-Aviv University Ltd., Tel HaShomer Medical Research Infrastructure and Services Ltd.
    Inventors: Amar N. Kar, Pabitra Sahoo, Jeffery Twiss, Sean McGill, Eran Perlson, Topaz Altman, Ariel Razvan Ionescu, Tal Gradus-Pery, Amir Dori
  • Patent number: 11617769
    Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic ?-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
    Type: Grant
    Filed: April 1, 2020
    Date of Patent: April 4, 2023
    Assignees: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah Ferber
  • Publication number: 20230051170
    Abstract: Embodiments described herein relate to a method for preparing cultured cells, the method comprising: obtaining kidney tissue from a human subject; mechanically dissociating the tissue; subjecting the tissue to enzymatic digestion; incubating the tissue with media in a cell culture plate to form cultured cells.
    Type: Application
    Filed: January 25, 2021
    Publication date: February 16, 2023
    Applicants: KIDNEYCURE LTD, TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD
    Inventors: Masha SIMANOVSKY, Benjamin DEKEL