Abstract: Split support catheters, loading tools, and methods of use are disclosed. A support catheter can include an elongate tubular member and a push member. The tubular member can comprise a longitudinal slit configured to accommodate the exchange of various interventional devices into and out of the lumen defined by the tubular member. A loading tool can comprise a body member, a rod member, or both and can facilitate loading of the support catheter onto one or more interventional devices during a medical procedure. The support catheters can provide intravascular support to various interventional devices and can advantageously be inserted and removed without first removing an interventional device having its distal end at or near a target site within a patient's vasculature.

Abstract: A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes a delivery device including a flexible portion that is suited to access target anatomy. The flexibility of an elongate portion of the delivery device can be varied. Additionally, the delivery device can include structure that maintains the positioning of the delivery device in patient anatomy.

Abstract: An apparatus for transferring mechanical energy in a handle to a cartridge to manipulate tissue or anatomical structures within the body of a human or animal subject for the purpose of treating diseases or disorders. The handle and cartridge contain safety interlocks.

Abstract: A vascular closure device includes a release component, a delivery component, a sealing device and at least one actuator. The release component is elongate along a longitudinal direction, and defines a distal end and a proximal end. The delivery component extends along the release component such that at least the release component is movable relative to the delivery component. The delivery component includes a delivery tube body and defines a delivery tube channel. The sealing device has a toggle that is at least partially disposed within the release tube, a suture that is attached to the toggle and extends through the delivery tube channel, and a plug that is attached to the suture proximal to the toggle.

Abstract: A system for treating internal bleeding via application of a heated irrigant, such that the heated irrigant is delivered at a flow rate of between 2 cc/s and 12 cc/s and at a temperature of between 46 degrees Celsius and 52 degrees Celsius.

Abstract: Methods for sealing a percutaneous puncture in a wall of a body passageway are disclosed herein. The methods include inserting a deployment instrument into the puncture via a toggle along the guidewire, and actuating the deployment instrument to move the first component and the second component relative to each other such that the toggle abuts the wall of the artery proximate the puncture to seal the puncture.

Abstract: Guidewires and methods for transmitting electrical stimuli to a heart and for guiding and supporting the delivery of elongate treatment devices within the heart are disclosed. A guidewire can comprise an elongate body, including first and second elongate conductors, and at least first and second electrodes. A distal end portion of the elongate body can include a preformed bias shape, such as a pigtail-shaped region, on which the first and second electrodes can be located. The preformed bias shape can optionally be non-coplanar relative to an intermediate portion of the elongate body. The first and second elongate conductors can be formed of a single structure or two or more electrically connected structures. The conductors can extend from proximal end portions to distal end portions that electrically connect to the first and second electrodes.

Abstract: Disclosed are puncture sealing systems and methods of locating a puncture site within a vessel. The systems can include puncture locating dilators and access sheaths that are configured to locate the puncture site within a vessel so that the position of the puncture site relative to a distal end of the access sheath is known during a puncture sealing procedure.

Abstract: The present technology relates generally to devices and methods for closing percutaneous punctures, and more particularly to a multi-lumen tamper for such a device. A vascular closure device for sealing a percutaneous puncture in a wall of a body passageway is disclosed, the vascular closure device including a plug configured to engage a surface of the puncture; a suture configured coupled to the plug; a locking member configured to engage the plug; and a tamper comprising a first lumen and a second lumen.

Abstract: Implant delivery systems are configured to deploy multiple implants into targeted tissue within a patient without disengaging a delivery component of the systems from its insertion site in the patient. Various combinations of spooling assemblies, spring-loaded features, manifolds, indexing mechanisms, gearings, and manually engageable actuators operate to deploy the implants in a controlled, serial fashion. Implants or portions thereof are pre-loaded into the handle assemblies of the delivery systems or contained in removable cartridges configured for coupling to the handle assemblies.

Abstract: Implant delivery systems are configured to deploy implants into targeted tissue within a patient. The targeted tissue includes at least a portion of a prostate gland, and the implants are configured to compress or retract the tissue. Implant delivery systems include handheld components. Irrigation systems control fluid inflow and outflow at the treatment site. Sheath devices deliver irrigant to a treatment site within a patient, and elongate shaft devices remove contaminated irrigant, blood, and debris. Visualization systems provide an unobstructed view of the treatment site during implant deployment.

Abstract: A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes a delivery device and a plurality of anchor assemblies. The delivery system is configured to deliver a first anchor using loaded energy and reload the energy required to deliver an addition anchor.

Abstract: A transurethral system for delivering and depositing fiducial markers usable to delineate the prostate during radiation therapy includes at least one implant or anchor assembly featuring a first anchoring component, a second anchoring component, and a connector. A delivery device featuring a handle assembly, an actuator, and an elongate member delivers the implant or anchor assembly to an interventional site.

Abstract: A closure device system for sealing a percutaneous puncture in a vessel wall can comprise a toggle configured to engage an interior surface of the vessel wall, a plug configured to engage an exterior surface of the vessel wall, and a suture that extends through the plug and through the toggle along at least a first direction so as to couple the toggle to the plug. The system can further comprise a tube that extends through the plug and through the toggle along the first direction such that a distal end of the tube is disposed distally to the toggle. The tube can define a guidewire lumen that extends therethrough along the first direction. And the guidewire lumen can be configured to receive a guidewire that protrudes from the vessel wall such that the plug, toggle, and tube are slidable along the guidewire toward the vessel wall.

Abstract: A guide extension catheter positionable within a guide catheter and configured to receive an interventional device for insertion into a vasculature is disclosed. The guide extension catheter can include a push member and a radially collapsible, tubular membrane in contact with the push member. The guide extension catheter may include a reinforcement member or proximal end cap positioned at the proximal end of the tube member and formed as a rigid, non-collapsible structure. The guide extension catheter may be delivered through another catheter, such as a guide catheter, in a compressed configuration, and then released to an expanded, non-compressed configuration when the guide extension catheter has been partially extended beyond a distal end of the guide catheter.

Abstract: A prostatic implant configured to compress an enlarged prostate gland includes a coil member having a distal portion connected to a proximal portion by a middle portion. The distal portion and proximal portion each define a pre-formed coil structure configured to anchor the implant to a lateral lobe of the prostate gland while the middle portion extends therethrough in a partially uncoiled configuration. The implant, which may be a single member of unitary construction, is self-tensioning such that after implantation, the middle portion biases the distal portion and proximal portion toward each other, across the prostatic tissue. The enlarged anchoring footprints of the pre-formed coil structures prevent the distal and proximal portions from tearing through the prostatic tissue in response to the inherent tension force of the implant.

Abstract: A prostatic implant configured to compress an enlarged prostate gland includes a distal anchor member and an expandable, proximal anchor member connected by a middle portion. The expandable, proximal anchor member is configured to expand upon being released from a tubular delivery device, such that the anchoring footprint of the expandable anchor member on the urethral side of a prostate gland is large relative to anchors having fixed dimensions. The expandable anchor member includes expandable portions configured to expand outwardly or laterally away from the body of the expandable anchor member, forming curved portions or wings. After anchoring the distal anchor member to the outer surface of the prostatic capsule, tension may be applied to the middle portion extended through the prostate gland. Attachment of the expandable anchor member to the middle portion at the urethral side of the gland locks the tension in place, retracting the enlarged prostatic tissue.

Abstract: A prostatic implant configured to compress an enlarged prostate gland includes a distal anchor portion and a proximal end portion connected by a middle portion. The distal anchor portion includes a distal piercing portion and a proximal tail portion. The distal piercing portion includes a sharp distal tip configured to penetrate a lobe of the prostate gland, including the firm prostatic capsule. A tubular push member coupled with the prostatic implant advances the implant distally, led by the distal piercing portion, until the proximal tail portion is positioned outside the prostatic capsule, at which point the tubular push member is retracted proximally, unsheathing the distal anchor portion of the implant. The proximal tail portion is biased such that, upon exiting the tubular push member, the tail portion extends away from a longitudinal axis of the tubular push member, across the outer surface of the capsule.

Abstract: A releasable elongated assembly includes a release member having a length and an opening that extends along the length. The releasable elongated assembly includes a first elongated element having a first coupling member disposed in the opening and a second elongated element having a second coupling member disposed in the opening opposite the first coupling member along the length. The first and second elongated elements are interlaced with each other in the opening at a location between the first coupling member and the second coupling member such that the first and second elongated elements are attached to each other. The release member is moveable from a first position where the first and second coupling members are captured in the opening to a second position where the first and second coupling members are released from the opening so as to detach the first and second elongated elements from each other.

Abstract: Closure systems, kits and methods for sealing a percutaneous puncture or other opening in a blood vessel wall, body cavity or biopsy tract are disclosed. A closure system can comprise an implant assembly, a delivery assembly, and an introducer sheath. The closure system can further comprise a valve bypass and a dilator. The implant assembly can include an inner member, a sealing membrane, and an outer member, each of which can be delivered by the delivery assembly. The inner member can be extended through the puncture or opening and positioned adjacent an inner tissue surface. The outer member can be positioned adjacent an outer tissue surface. The sealing membrane can have a distal end attached to the inner member, a proximal end including an opening configured to receive the outer member, and a mid-region therebetween.