Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.
Type:
Application
Filed:
October 13, 2017
Publication date:
October 4, 2018
Applicant:
Telomerase Activation Sciences, Inc.
Inventors:
Calvin Bruce HARLEY, Soo-Peang KHOR, Mahesh RAMASESHAN, Premchandran H. RAMIYA, Zhu Z. PIROT, Steven FAUCE, Tong LIN
Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.
Type:
Grant
Filed:
December 10, 2015
Date of Patent:
March 13, 2018
Assignee:
TELOMERASE ACTIVATION SCIENCES, INC.
Inventors:
Calvin Bruce Harley, Soo-Peang Khor, Mahesh Ramaseshan, Premchandran H. Ramiya, Zhu Z. Pirot, Steven Fauce, Tong Lin
Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.
Type:
Grant
Filed:
July 8, 2013
Date of Patent:
August 2, 2016
Assignee:
TELOMERASE ACTIVATION SCIENCES, INC.
Inventors:
Calvin Bruce Harley, Soo-Peang Khor, Mahesh Ramaseshan, Premchandran H. Ramiya, Zhu Z. Pirot, Steven Fauce, Tong Lin
Abstract: Methods and cosmetic compositions for conditioning the skin, utilizing as active ingredients selected compounds structurally related to astragenols, cycloastragenols, and/or protopanaxatriols, are provided. Such compounds include those of formulas (I), (II) and (III) described herein.
Type:
Grant
Filed:
June 24, 2004
Date of Patent:
February 2, 2016
Assignee:
TELOMERASE ACTIVATION SCIENCES, INC.
Inventors:
Calvin B. Harley, Allison C. Chin, Tsutomu Akama, Nancy Yuk-yu Ip, Yung-hou Wong
Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin ailments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.
Type:
Grant
Filed:
March 5, 2010
Date of Patent:
June 24, 2014
Assignee:
Telomerase Activation Science, Inc.
Inventors:
Calvin Bruce Harley, Allison C. Chin, Tsutomu Akama, Nancy Yuk-yu Ip, Yung-hou Wong, David M. Miller-Martini
Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.
Type:
Application
Filed:
July 8, 2013
Publication date:
March 27, 2014
Applicant:
TELOMERASE ACTIVATION SCIENCES, INC.
Inventors:
Calvin Bruce HARLEY, Soo-Peang KHOR, Mahesh RAMASESHAN, Premchandran H. RAMIYA, Zhu Z. PIROT, Steven FAUCE, Tong LIN
Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.
Type:
Grant
Filed:
May 17, 2010
Date of Patent:
July 9, 2013
Assignee:
Telomerase Activation Sciences, Inc.
Inventors:
Calvin B. Harley, Soo-Peang Khor, Mahesh Ramaseshan, Premchandran Ramiya, Zhu Zhen Pirot, Steven Fauce, Tong Lin