Patents Assigned to Temasek Life Sciences Laboratory
  • Patent number: 10844418
    Abstract: The present invention relates to the field of diagnostics and more particularly to the detection of beta-hemolytic pathogens. More specifically, the present invention relates to the rapid and accurate detection of beta-hemolytic pathogens using sterically-stabilized liposomes.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: November 24, 2020
    Assignee: TEMASEK LIFE SCIENCES LABORATORY
    Inventors: Rongji Sum, Muthukaruppan Swaminathan, Ian Cheong
  • Patent number: 8586824
    Abstract: A group of genes including GhCIR1 from cotton (Gossypium hirsutum), and AtCIR1 and AtCIR2 from Arabidopsis thaliana promote shoot regeneration in plants even in the absence of cytokinin. In the presence of cytokinin, the genes significantly improve transformation efficiency. The genes can be used as an enhancer as well as a selectable marker of transformation in plants. The proteins encoded by the novel genes have a homeodomain (HD) at the N-terminus and a highly divergent domain at the C-terminus. The proteins share a common structural motif.
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: November 19, 2013
    Assignee: Temasek Life Sciences Laboratory
    Inventors: Lianghui Ji, Lin Cai, Nam-Hai Chua
  • Patent number: 8389027
    Abstract: The present invention provides methods of isolating cytotoxic metabolites from a fungus, and specific metabolites obtained from such methods. The present invention also provides methods of controlling fungal diseases in plants by treating the plants with cytotoxic metabolites as well as methods of treating cardiac arrhythmia in organisms in need of such treatment by administering the above-noted metabolites to such organisms.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: March 5, 2013
    Assignee: Temasek Life Sciences Laboratory
    Inventors: Rajesh Narhari Patkar, Naweed Isaak Naqvi
  • Patent number: 8334427
    Abstract: The present invention generally provides a method to generate broad-spectrum resistance to bacterial blight disease in plants. More specifically, the present invention provides a method to generate broad-spectrum resistance to Xanthomonas oryzae pv. oryzae, the causal agent of bacterial blight disease of rice, and enhanced resistance to Xanthomonas oryzae pv. oryzicola, the causal agent of bacterial leaf streak of rice. Xa27, an inducible bacterial blight R gene in rice, was induced by the cognate avrXa27 gene expressed in host. Rice plants carrying the avrXa27 transgene and wild-type Xa27 gene conferred resistance to incompatible and compatible pathogens, and enhanced resistance to X. oryzae pv. oryzicola strain L8. The Xa27-mediated enhanced resistance to X. oryzae pv. oryzicola was also observed in the interaction between IRBB27 and L8 harboring pHM1avrXa27. This was further verified by the fact that the Xa27 gene in IRBB27 was induced by the avrXa27 gene in bacteria.
    Type: Grant
    Filed: January 8, 2008
    Date of Patent: December 18, 2012
    Assignee: Temasek Life Sciences Laboratory
    Inventors: Zhongchao Yin, Dongsheng Tian
  • Patent number: 8193160
    Abstract: In Magnaporthe species and other plant pathogenic fungal species, the appressoriu, (infection structure) is responsible for breaching the host plant cell wall and gaining entry into the host tissues. Magnaporthe ABC3 protein is an MDR transporter that plays an important role during host penetration and also is involved in regulating fungal response to intracellular oxidative stress. The insertional mutant abc3?, in which the ABC3 efflux pump function is blocked, lacks functional appressoria and is therefore incapable of causing disease in host plants. This invention provides the abc3 nucleic acid (gene) and ABC3 protein from Magnaporthe or from Aspergillus, Ustilago or Fusarium and describes methods for reducing plant pathogenicity for important rice pathogens.
    Type: Grant
    Filed: March 14, 2007
    Date of Patent: June 5, 2012
    Assignee: Temasek Life Sciences Laboratory
    Inventors: Naweed Isaak Naqvi, Chuan Bao Sun
  • Publication number: 20100293662
    Abstract: A group of genes including GhCIR1 from cotton (Gossypium hirsutum), and AtCIR1 and AtCIR2 from Arabidopsis thaliana promote shoot regeneration in plants even in the absence of cytokinin. In the presence of cytokinin, the genes significantly improve transformation efficiency. The genes can be used as an enhancer as well as a selectable marker of transformation in plants. The proteins encoded by the novel genes have a homeodomain (HD) at the N-terminus and a highly divergent domain at the C-terminus. The proteins share a common structural motif.
    Type: Application
    Filed: February 13, 2006
    Publication date: November 18, 2010
    Applicant: TEMASEK LIFE SCIENCES LABORATORY
    Inventors: Lianghui Ji, Lin Cai, Nam-Hai Chua
  • Publication number: 20070092938
    Abstract: This invention relates to Severe Acute Respiratory Syndrome associated coronavirus (SARS virus) isolated and recombinant proteins, in particular the nucleocapsid (N) protein and spike (S) protein, as well as fragments thereof and their use in the diagnosis, treatment and prevention of Severe Acute Respiratory Syndrome (SARS). The proteins and fragments carry epitopes that are specific for the SARS virus. Thus, detection methods based on these proteins or fragments as well as the monoclonal antibodies against these proteins or fragments are specific for the SARS virus.
    Type: Application
    Filed: February 4, 2004
    Publication date: April 26, 2007
    Applicant: Temasek Life Sciences Laboratory
    Inventors: Jimmy Kwang, Ai Ling, Eng Ooi, Hiok Chng
  • Patent number: 7151206
    Abstract: The present invention is directed to a novel auxin-inducible gene, ARGOS, that is involved in organ development, including size control, in plants. Methods of influencing this development are also described, as are transformed cells and transgenic plants comprising the described sequences.
    Type: Grant
    Filed: November 18, 2003
    Date of Patent: December 19, 2006
    Assignee: Temasek Life Sciences Laboratory
    Inventors: Yuxin Hu, Qi Xie, Nam-Hai Chua
  • Patent number: 7132526
    Abstract: The present invention relates to an anther-specific cotton gene (CoFS), and active promoter fragments thereof. These promoters show strong anther-specific activity.
    Type: Grant
    Filed: January 17, 2001
    Date of Patent: November 7, 2006
    Assignee: Temasek Life Sciences Laboratory
    Inventors: Jian-Wei Liu, Xuebao Li, Lin Cai, Ninghui Cheng
  • Publication number: 20050108793
    Abstract: The present invention is directed to a novel auxin-inducible gene, ARGOS, that is involved in organ development, including size control, in plants. Methods of influencing this development are also described, as are transformed cells and transgenic plants comprising the described sequences.
    Type: Application
    Filed: November 18, 2003
    Publication date: May 19, 2005
    Applicant: Temasek Life Sciences Laboratory
    Inventors: Yuxin Hu, Qi Xie, Nam-Hai Chua
  • Patent number: 6844486
    Abstract: A novel gene, nacl, has been isolated from Arabidopsis. This gene encodes a protein (NACl) which has been identified as a member of the NAC family. NACl shares a high amino acid sequence homology with other members of the NAC gene products in the N-terminus. Data show that NACl belongs to a newly identified family of transcription factors. NACl is involved in the regulation of cotyledon and lateral root development. Overexpression of the gene can lead to larger plants with larger roots and more lateral roots than in wild-type plants.
    Type: Grant
    Filed: February 11, 1999
    Date of Patent: January 18, 2005
    Assignee: Temasek Life Sciences Laboratory
    Inventors: Qi Xie, Nam-Hai Chua