Abstract: An apparatus for the magnetic treatment of a fluid which produces at least one magnetic field for a period of time, Tc at or above a critical magnetic field strength, Hc, the period Tc and the field strength Hc determined relative to one another and dependant upon the properties of the fluid.
Type:
Application
Filed:
March 13, 2012
Publication date:
September 13, 2012
Applicant:
Temple University of the Commonwealth of System of Higher Education
Abstract: A method for determining whether early stage cancer is present in a subject comprises detecting the expression level of GASP-1 in the subject by detecting the amount of GASP-1 peptide fragments present in a biological sample of the subject. Because cancer can be detected at an early stage, therapeutic targeting may be initiated before cancer reaches late stage (e.g., before the development of overt symptoms). A method for treating early stage cancer in a subject comprises administering to the subject an effective amount of a GASP-1 inhibitor to inhibit the progression of early stage cancer to late stage cancer. A Competitive ELISA capable of detecting GASP-1 peptide fragments at a concentration of less than 1 ng/ml was developed.
Type:
Application
Filed:
May 4, 2012
Publication date:
August 30, 2012
Applicant:
Temple University of the Commonwealth System of Higher Education
Abstract: Methods for identifying disease-specific markers, in particular breast cancer markers, by electrophoretically separating serum albumin complexes in a biological sample on a membrane are provided. Electrophoretic separation profiles representing different diseases or different cancer stages can be produced, and used in the diagnosis, prognosis and treatment of these diseases. Methods for identification of a cancer peptide fragment comprising a cancer peptide motif are provided. Also provided are breast cancer and other cancer markers and antibodies that specifically recognize these markers.
Type:
Application
Filed:
July 13, 2010
Publication date:
July 19, 2012
Applicant:
Temple University of the Commonwealth System of Higher Education
Inventors:
Frank N. Chang, Phu T. Duong, George P. Tuszynski
Abstract: A method of screening an antioxidant for potency and/or toxicity in vitro, the method includes contacting the antioxidant with a model system containing a sterol superlattice formation capable of generating a detectable signal, wherein the detectable signal changes in a parameter representative of an integrity of the sterol superlattice formation; and detecting and/or measuring disruption of the sterol superlattice formation, wherein the disruption is caused by the insertion of the antioxidant into membranes and thereby screening the antioxidant for potency and/or toxicity.
Type:
Grant
Filed:
July 25, 2008
Date of Patent:
May 22, 2012
Assignee:
Temple University- Of the Commonwealth System of Higher Education
Abstract: Compounds are provided having agonistic activity against G protein-coupled receptor 35 (GPR35). The compounds are useful for providing antinociception, providing neuroprotection in case of stroke or ischemia, or treating gastric inflammation.
Type:
Application
Filed:
July 14, 2010
Publication date:
May 17, 2012
Applicants:
Temple University of the Commonwealth System of Higher Education, Research Triangle Institute, Duke University
Inventors:
Mary E. Abood, Pingwei Zhao, Lawrence S. Barak, Herbert H. Seltzman
Abstract: An apparatus for the magnetic treatment of a fluid which produces at least one magnetic field for a period of time, Tc at or above a critical magnetic field strength, Hc, the period Tc and the field strength Hc determined relative to one another and dependant upon the properties of the fluid.
Type:
Grant
Filed:
May 13, 2005
Date of Patent:
May 8, 2012
Assignee:
Temple University of the Commonwealth System of Higher Education
Abstract: Peptides are provided having leptin receptor agonist activity. The peptides are useful for treating obesity, type II diabetes, appetite control after bariatric surgery, insulin resistance, lipodystrophy and hypothalamic amenorrhea, obesity-related infertility, among other diseases and conditions related to leptin deficiency and/or leptin resistance.
Type:
Application
Filed:
June 25, 2010
Publication date:
May 3, 2012
Applicant:
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Abstract: The present invention relates to a method for reducing the viscosity and facilitating the flow of petroleum-based fluids. The method includes the step of applying an electric field of sufficient strength and for a sufficient time to the petroleum-based fluid to cause a reduction in viscosity of the fluid.
Type:
Grant
Filed:
December 13, 2005
Date of Patent:
April 17, 2012
Assignee:
Temple University of the Commonwealth System of Higher Education
Abstract: Compounds of Formula I: wherein R1, R2, M, Q and n are as defined herein, are useful as antiproliferative agents including, for example, as anticancer agents.
Type:
Grant
Filed:
June 8, 2005
Date of Patent:
March 27, 2012
Assignee:
Temple University-Of The Commonwealth System of Higher Education
Abstract: Methods and systems for detecting nuclear material concealed within an enclosure are provided. An ionized air density is measured at one or more locations outside of the enclosure. The presence of the concealed nuclear material is detected, for each of the one or more locations, based on a characteristic of the measured ionized air density indicative of concealed nuclear materials.
Type:
Application
Filed:
February 5, 2010
Publication date:
February 2, 2012
Applicants:
U.S. Naval Research Laboratory, Temple University of the Commonwealth System of Higher Education
Abstract: Methods and compositions are provided for treating proliferative disorders, wherein the composition comprises at least one compound according to Formula I: wherein R1 is selected from the group consisting of —OH, —NH2, —NH—CH2—CO2H, —NH—CH(CH3)—CO2H, and —NH—C(CH3)2—CO2H, or a pharmaceutically acceptable salt of such a compound; and an anthracycline, e.g. doxorubicin, or a pharmaceutically acceptable salt thereof, or a platin, e.g. oxaliplatin, or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
March 10, 2006
Date of Patent:
January 31, 2012
Assignees:
Temple University - Of The Commonwealth System of Higher Education, Mount Sinai School of Medicine
Abstract: An orthotic shoe sole assembly and an orthotic insole are disclosed herein. The orthotic shoe assembly includes a shoe sole having an exposed surface and at least one exposed cavity accessible via the exposed surface. The at least one exposed cavity includes a central region and a plurality of channels extending from the central region. A resilient member is removably positioned within the central region of the exposed cavity. The resilient member is configured to resiliently expand into at least one of the plurality of channels of the exposed cavity. The orthotic insole is removably positioned to selectively conceal the exposed cavity of the shoe sole and the resilient member. The orthotic insole includes a central axis member for supporting a foot along its central axis.
Type:
Application
Filed:
October 26, 2009
Publication date:
January 26, 2012
Applicant:
Temple University of the Commonwealth System of Higher Education
Inventors:
Kendrick Whitney, James McGuire, Richard Posoff
Abstract: This invention provides methods of producing a crosslinked lipid coating on a metal sulfide-containing material using a chemical initiator. The crosslinked lipid coating attached to the surface of the material prevents dissolution or oxidation of the material. The methods may be useful to prevent oxidation and leaking of sulfide-containing material in the environment and may be used in the control of environmental pollution.
Type:
Application
Filed:
March 4, 2010
Publication date:
January 26, 2012
Applicants:
THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK, STONY BROOK, TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Inventors:
Daniel R. Strongin, Martin Schoonen, JUn Hao
Abstract: Methods for identifying modulators of gastroesophageal smooth muscle relaxation include isolating various types of smooth muscle fibers from the stomach or esophagus and inducing the fibers to contract. The isolated and contracted fibers are used to screen test compounds for the compound's capacity to modulate relaxation of the smooth muscle fibers. In addition, newly identified unique nicotinic acetylcholine receptors are expressed in a cell, and used to screen test compounds for the compound's capacity to modulate the biological activity of the receptors.
Type:
Application
Filed:
June 21, 2011
Publication date:
December 1, 2011
Applicant:
Temple University of the Commonwealth System of Higher Education
Inventors:
Michael R. Ruggieri, Larry S. Miller, Alan S. Braverman, Anil K. Vegesna, Mary F. Barbe
Abstract: Compounds of Formula I: wherein R1, R2, M, Q and n are as defined herein, are useful as antiproliferative agents including, for example, as anticancer agents.
Type:
Grant
Filed:
June 2, 2006
Date of Patent:
November 29, 2011
Assignee:
Temple University-Of The Commonwealth System of Higher Education
Abstract: Methods are presented for the therapeutic administration of angiocidin in the treatment of cancers such as glioma, breast cancer, and leukemia. Methods are also presented for inducing growth arrest and/or apoptosis of tumor cells, as well as inducing differentiation of tumor cells to inhibit tumorigenicity and to confer a non-tumor or healthy phenotype.
Type:
Application
Filed:
November 20, 2009
Publication date:
November 24, 2011
Applicant:
TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Inventors:
George P. Tuszynski, John F. Wong, Taffy Williams
Abstract: An apparatus and method for sharing a secret comprising the steps of generating a first random matrix, generating a first projection matrix from the first random matrix, and determining a first remainder matrix from the first projection matrix and the first secret matrix. The first secret matrix may be determined using the remainder matrix and a plurality of distributed vector shares.
Type:
Grant
Filed:
May 3, 2006
Date of Patent:
November 15, 2011
Assignee:
Temple University of the Commonwealth System of Higher Education
Abstract: A method for removing impurities from carbon nanotubes is described. Impurities may be removed from the carbon nanotubes by exposing the carbon nanotubes to a temperature, and controlling the temperature such that the temperature is constantly increasing to remove at least a portion of the impurities from the carbon nanotubes.
Type:
Application
Filed:
November 11, 2009
Publication date:
November 10, 2011
Applicant:
Temple University - of the Commonwealth System of Higher Education
Abstract: A locking rod fusion device and method uses internal locking rods and screws that will lock together. In particular, the device allows the insertion of multiple locking rods in combination with a plate, which requires less dissection and disruption of soft tissues and vasculature. The device also provides a more stable internal construct for fusions that prevent non-unions, hardware failure and reoccurrence of deformities, such as Charcot foot. The device combines the strength of locking technology and the utility and ease of an internal rod system to provide a single stable construct in multiple planes as apposed to using multiple plates or screws separately.
Type:
Application
Filed:
November 10, 2009
Publication date:
October 13, 2011
Applicant:
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Abstract: Functionalized bis-peptides as well as other amide-containing compounds are obtained by acylation of hindered amines. The functionalized bis-peptides are useful as shape-programmable nanostructures that are immune to denaturation and that contain arrays of functional groups having designed catalytic, protein-binding and/or sensor capabilities.
Type:
Application
Filed:
January 14, 2011
Publication date:
July 28, 2011
Applicants:
TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Inventors:
Christian E. Schafmeister, Zachary Z. Brown