Abstract: The present invention provides homologous recombination vectors to insert transgenic DNA in cells. These vectors shorten the production time and allow for easy generation of genetically modified cells. The invention allows the user to test multiple tags and to generate homozygous modified cell line using the homologous recombination vector. The invention can be used to generate knockout cells, to generate cell lines with knockin genes, to generate cell lines for drug screening against any target, to create transgenic animals, or in gene therapy.

Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

Abstract: A magnetometer-based metal detection device and methods of use are described. The device includes a proximal portion, a central body and a distal portion, and at least one magnetometer positioned within or on the distal portion. The at least one magnetometer includes at least one sensor capable of sensing a magnetic field in three orthogonal axes. Also described is a method of calibrating the device to achieve rotational invariance, and a method of determining a directionality or directional line along which a target metal object lies.

Abstract: The present invention discloses a photon enhancement apparatus comprising a reflective component and 4f coherent imaging system, which increases a photon collection efficiency. The present invention also provides a microscope comprising said photon enhancement apparatus and methods of improving photon collection efficiency, signal-to-noise ratio, and/or optical resolution using the said photon enhancement apparatus.

Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

Abstract: Compositions for specifically cleaving target sequences in retroviruses include nucleic acids encoding a Clustered Regularly Interspace Short Palindromic Repeat (CRISPR) associated endonuclease and a guide RNA sequence complementary to one or more target nucleic acid sequences in a retrovirus genome.

Abstract: Compositions and methods for the promotion of wound healing and tissue regeneration are described. The compositions and methods make use of water-soluble soy protein isolates (WSsoy), Fraction 5, Fraction 9, and/or bioactive peptide components of soy protein isolates. The invention also relates to the unexpected discovery that purified WSsoy forms gel-like matrices when suspended within certain concentration ranges in an aqueous environment. The compositions of the invention comprising WSsoy promote natural healing and have a low risk profile.

Abstract: A method of assessing the balance impairment of a subject includes the steps of presenting the subject with a static scene on a display, collecting a first set of orientation measurements, presenting the subject with an unstable scene on a display, collecting a second set of orientation measurements, storing the first and second sets of orientation measurements on a computing device, referenced to a set of time indices, and calculating a balance score for the subject by comparing the second set of orientation measurements with the first set of orientation measurements. A system for assessing the balance impairment of a subject is also disclosed.

Abstract: The present invention features compositions comprising an anti-amyloid antibody and methods of treating microbial infection and treating or preventing microbial biofilms using the composition.

Abstract: The present application provides compounds and methods of treating bacterial infection, including bacterial infection caused by P. acnes.

Abstract: The present invention relates in part to a filter comprising a tubular housing having a proximal end, a distal end and a housing lumen therethrough; a tubular membrane having a proximal end, a distal end and a membrane lumen therethrough, wherein the tubular membrane is positioned within the housing lumen; a contaminated fluid sample inlet fluidly connected to the proximal end of the membrane, and a contaminated fluid sample outlet fluidly connected to the distal end of the membrane, thereby creating a sample flow-path from the sample inlet through the membrane lumen to the sample outlet; and a purification material inlet fluidly connected to a distal region of the housing lumen, and a purification material outlet fluidly connected to a proximal region of the housing lumen, thereby creating a purification material flow-path from the purification material inlet through the housing lumen to the purification material outlet; wherein the direction of the sample flow-path is in the opposite direction of the purifi

Abstract: Compositions for the in vivo delivery of a gene editing CRISPR/Cas9 complex was developed to eliminate integrated retroviral DNA sequences from latently infected human cells and animal disease models.

Abstract: The present invention relates in part to a method of fabricating a ceramic-polymer composite by contacting a polymer material with an acid solution and depositing a ceramic on the polymer material. The invention also relates in part to ceramic-polymer composites produced using said method and ballistic resistant materials comprising said ceramic-polymer composites.

Abstract: The present invention relates to pyrazolylbenzene-1,3-diols as cannabidiol derivatives, its use for the manufacture of a medicament, and more particularly, to the use of this medicament for the treatment and/or prevention of a disorder associated with the GPR18 and/or TRPV1 receptors and the use of these compounds for pharmacological assays related to GPR18 and/or TRPV1.

Abstract: The present invention provides portable devices and systems for electrofocused blow spinning, and methods for using the same. The devices of the invention are convenient to carry and use and are able to aerodynamically spin a variety of materials in a mobile setting.

Abstract: The invention provides compositions and methods for generating improved T cells having increased Ezh2 activity and methods of use thereof in the treatment of cancer and chronic infection.

Abstract: The invention provides AML-specific methylation biomarkers (SP140, MCCC1, EHMT1 and MTSS1). In one embodiment, a biomarker is differentially methylated, specifically in AML.

Abstract: The present invention provides a semi-quantitative phage-based assay for Mycobacterial infection, in which the phage assay plaque count correlates to the number of viable Mycobacterial organisms in the subject sample, and methods of use thereof for diagnosing, treating or monitoring Mycobacterial infection.

Abstract: The invention provides compositions and methods for modifying the 3?-terminal ends of nucleic acids using DNA polymerase ? terminal transferase activity.