Patents Assigned to Temple University of the Commonwealth System of Higher Education
  • Patent number: 10961249
    Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of sigma-2 receptor activity.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: March 30, 2021
    Assignee: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Benjamin E. Blass, Daniel J. Canney, Kevin M. Blattner
  • Patent number: 10962555
    Abstract: The present invention provides for the first time the identification of fetal neural exosomal biomarkers isolated from maternal plasma useful in diagnosing fetal neurodevelopmental outcomes. The invention also provides the identification of neonatal neural exosomal biomarkers isolated from neonatal plasma useful in diagnosing neonatal neurodevelopmental outcomes The present invention therefore provides methods, kits and systems for diagnosing fetal neurodevelopmental outcomes, by examining relevant proteins and RNA in fetal neural exosomes isolated from a maternal plasma and neonatal neural exosomes isolated from neonatal plasma.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: March 30, 2021
    Assignee: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Laura Goetzl, Edward Goetzl
  • Patent number: 10941126
    Abstract: The present invention includes novel bridged bicycloalkyl-substituted aminothiazole compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: March 9, 2021
    Assignee: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Wayne C. Childers, Magid A. Abou-Gharbia, George C. Morton, Jean-Pierre J. Issa, Hanghang Zhang
  • Publication number: 20210060138
    Abstract: Methods of eliminating a retrovirus from a subject utilize nanoformulated anti-retroviral compounds and gene editing agents. Compositions comprise at least one anti-retroviral compounds, at least one gene-editing agent, or combinations thereof.
    Type: Application
    Filed: March 6, 2020
    Publication date: March 4, 2021
    Applicants: Temple University - of the Commonwealth System of Higher Education, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Kamel Khalili, Howard E. Gendelman, Benson Edagwa
  • Publication number: 20210052532
    Abstract: In certain embodiments, this disclosure relates to methods of treating or preventing type 2 diabetes, pre-diabetes and conditions characterized by an increase in the levels of A1C, glucose, insulin, homeostasis model of assessment of insulin resistance HOMA-IR), oxidative stress in adipose tissue, and earbonvlation of GLUT4 comprising administering an effective amount of a compound of Formula I-III as described herein, to a subject in need thereof.
    Type: Application
    Filed: March 7, 2019
    Publication date: February 25, 2021
    Applicant: Temple University - Of The Commonwealth System Of Higher Education
    Inventors: Salim MERALI, Carlos A. BARRERO, Wayne E. CHILDERS, George C. MORTON
  • Publication number: 20210017600
    Abstract: Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided.
    Type: Application
    Filed: May 21, 2020
    Publication date: January 21, 2021
    Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Arthur M. Feldman, Douglas G. Tilley, Weizhong Zhu, Kamel Khalili, Walter J. Koch
  • Patent number: 10883120
    Abstract: The present invention provides homologous recombination vectors to insert transgenic DNA in cells. These vectors shorten the production time and allow for easy generation of genetically modified cells. The invention allows the user to test multiple tags and to generate homozygous modified cell line using the homologous recombination vector. The invention can be used to generate knockout cells, to generate cell lines with knockin genes, to generate cell lines for drug screening against any target, to create transgenic animals, or in gene therapy.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: January 5, 2021
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventor: Oscar M. Perez-Leal
  • Patent number: 10843243
    Abstract: The present invention relates to methods and compositions for water treatment and environmental remediation using nanoparticle supported lipid bilayers (NP-SLBs). In one embodiment, the NP-SLBs are single or multilayer lipid bilayers of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) supported by silica.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: November 24, 2020
    Assignee: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Stephanie L. Wunder, Bojeong Kim
  • Patent number: 10835620
    Abstract: This invention is generally related to novel compositions for treating or preventing heart failure. Specifically, the disclosure provides a composition comprising an amino-terminal domain of Beta.adrenergic receptor kinase-1 (Beta.ARKnt) peptide, or a nucleic acid encoding Beta.ARKnt. Further disclosed are methods of using the compositions for treating or preventing heart failure in a subject or for altering Beta.-adrenergic receptor (Beta.AR) density in a subject.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: November 17, 2020
    Assignee: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Walter J. Koch, Sarah M. Schumacher-Bass
  • Publication number: 20200205665
    Abstract: A mobile-platform imaging device uses compression of the target region to generate an image of an object. A tactile sensor has an optical waveguide with a flexible, transparent first layer. Light is directed into the waveguide. Light is scattered out of the first layer when the first layer is deformed. The first layer is deformed by the tactile sensor being pressed against the object, A force sensor detects a force pressing the tactile sensor against the object and outputs corresponding force information. A first communication unit receives the force information from the force sensor. A receptacle holds a mobile device with a second communication unit and an imager that can generate image information using light scattered out of the first layer. The first communication unit communicates with the second communication unit and the mobile device communicates with an external network.
    Type: Application
    Filed: July 26, 2018
    Publication date: July 2, 2020
    Applicant: Temple University - Of The Commonwealth System Of Higher Education
    Inventor: Chang-Hee WON
  • Patent number: 10682320
    Abstract: This invention provides a composition comprising Formula I, or salt thereof, wherein X is either chlorine or bromine, Y is either hydrogen or an alkyl group having a carbon chain length from 1 to 5 carbon atoms, and R is an alkyl group having a carbon chain length from 1 to 5 carbon atoms, except that X is not chlorine when Y is hydrogen and R is an ethyl group. A method of preventing bone erosion in a patient and a method of reducing inflammation in a patient using the compositions of Formula I are disclosed.
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: June 16, 2020
    Assignees: West Virginia University, Temple University-Of the Commonwealth System of Higher Education, University of Pittsburgh-Of the Commonwealth System of Higher Education
    Inventors: John B. Barnett, Harry C. Blair, Jonathan Soboloff
  • Patent number: 10676464
    Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: June 9, 2020
    Assignee: Temple University Of The Commonwealth System of Higher Education
    Inventors: Daniel J. Canney, Benjamin E. Blass, Rong Gao, Magid Abou-Gharbia
  • Publication number: 20200124275
    Abstract: Aspects of the invention are directed to systems and apparatuses for efficiently burning fuels. According to one aspect of the invention, apparatus for efficiently burning hydrocarbons includes a housing having a first opening for receiving a fuel, a second opening for expelling the fuel, and a tubular passageway extending between the first opening and the second opening. The tubular passageway includes a central region and an outer region surrounding the central region. The apparatus also includes a plurality of magnets disposed within the passageway. Each of the magnets has a spherical or an ovoid shape. The plurality of magnets define void spaces for passing the fuel such that a central flow rate of the fuel in the central region of the passageway is equivalent to the an outer flow rate of the fuel in an outer region of the passageway.
    Type: Application
    Filed: June 25, 2018
    Publication date: April 23, 2020
    Applicant: Temple University of the Commonwealth System of Higher Education
    Inventors: Oleksandr DILOYAN, Haykazuni ANDREASYAN
  • Publication number: 20190367493
    Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.
    Type: Application
    Filed: May 14, 2019
    Publication date: December 5, 2019
    Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Daniel J. CANNEY, Benjamin E. BLASS, Rong GAO, Magid ABOU-GHARBIA
  • Publication number: 20190367924
    Abstract: Compositions for specifically cleaving target sequences in retroviruses include nucleic acids encoding a Clustered Regularly Interspace Short Palindromic Repeat (CRISPR) associated endonuclease and a guide RNA sequence complementary to a target sequence in a retrovirus and a receptor used by a retrovirus for infecting a cell. The CRISPR construct edits, for example, proviral HIV DNA, thereby eliminating the provirus from an infected cell and simultaneously edits a viral receptor, e.g. CCR5 preventing infection and reinfection of the host.
    Type: Application
    Filed: February 16, 2018
    Publication date: December 5, 2019
    Applicant: Temple University - of the Commonwealth System of Higher Education
    Inventors: Kamel Khalili, Rafal Kaminski, Thomas Malcolm
  • Patent number: 10398142
    Abstract: The present disclosure provides an antimicrobial composition including a polycationic amphiphile compound, and the method of making and the method of using such a compound or composition. The compound having the formula R1, R2, R3, R4, R5, R6, R10, or R11 is H or a C1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR?, —NH2, —NHR?, —NR?2, —N—C(O)R?, —N—C(O)CR??CR?, —SH, —SR?, —O—C(O)R?, —C(O)R?, —CF3, —OCF3, halogen, benzyl, o-vinylbenzyl, m-vinylbenzyl, p-vinylbenzyl, phenyl, allyl, and substituted allyl. R7, R8 or R9 is a C1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR?, —NH2, —NHR?, —SH, —SR?, —O—C(O)R?, —C(O)R?, —CF3, and —OCF3. R? is H or a C1-4 alkyl. X or Y is a halogen. m and n are integers in the range from 1 to 25.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: September 3, 2019
    Assignees: Temple University of the Commonwealth System of Higher Education, Villanova University
    Inventors: William Wuest, Kevin Patrick Minbiole
  • Patent number: 10393914
    Abstract: Methods and systems for detecting nuclear material concealed within an enclosure are provided. An ionized air density is measured at one or more locations outside of the enclosure. The presence of the concealed nuclear material is detected, for each of the one or more locations, based on a characteristic of the measured ionized air density indicative of concealed nuclear materials.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: August 27, 2019
    Assignees: US Gov't Represented By Secretary Of The Navy Chief Of Naval Research, Temple University Of The Commonwealth System Of Higher Education
    Inventors: Rongjia Tao, Dong Ho Wu
  • Publication number: 20190247470
    Abstract: A method of eliminating the risk of JCV activation in a subject undergoing immunosuppressive therapy, by administering an effective amount of a gene editing composition directed toward at least one target sequence in the JCV genome, cleaving the target sequence in the JCV genome, disrupting the JCV genome, eliminating the JCV infection, eliminating the risk of JCV activation, and treating the subject with an immunosuppressive therapy. A pharmaceutical composition including at least one isolated nucleic acid sequence encoding a CRISPR-associated endonuclease and at least one gRNA having a spacer sequence complementary to a target sequence in a JCV DNA, the isolated nucleic acid sequences being included in at least one expression vector. Pharmaceutical compositions including at least one isolated nucleic acid sequence encoding at least one TALEN, at least one ZFN, and gene editing composition of C2c1, C2c3, TevCas9, Archaea Cas9, CasY.1-CasY.
    Type: Application
    Filed: April 29, 2019
    Publication date: August 15, 2019
    Applicants: Excision Bio Therapeutics, Inc., Temple University of the Commonwealth System of Higher Education
    Inventors: Kamel Khalili, Thomas Malcolm, Kenneth I. Kohn
  • Patent number: 10316061
    Abstract: A novel cell penetrating peptide that transports proteins into cells and/or into nuclei and a pharmaceutical containing the peptide is described.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: June 11, 2019
    Assignee: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Won Hyuk Suh, Geunwoo Jin
  • Patent number: 10287274
    Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: May 14, 2019
    Assignee: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Daniel J. Canney, Benjamin E. Blass, Rong Gao, Magid Abou-Gharbia