Abstract: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.
Type:
Application
Filed:
January 26, 2012
Publication date:
November 14, 2013
Applicants:
UNIVERSITY OF ROCHESTER, TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER LEARNING, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
Inventors:
Paul M. Dunman, Patrick D. Olson, Wayne Childers
Abstract: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease.
Type:
Application
Filed:
January 26, 2012
Publication date:
November 7, 2013
Applicants:
UNIVERSITY OF ROCHESTER, TEMPLE UNIVERSITY--OF THE COMMONWEALTH SYSTEM OF HIGHER LEARNING, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
Inventors:
Paul M. Dunman, Patrick D. Olson, Wayne Childers