Abstract: A magnetometer-based metal detection device and methods of use are described. The device includes a proximal portion, a central body and a distal portion, and at least one magnetometer positioned within or on the distal portion. The at least one magnetometer includes at least one sensor capable of sensing a magnetic field in three orthogonal axes. Also described is a method of calibrating the device to achieve rotational invariance, and a method of determining a directionality or directional line along which a target metal object lies.
Type:
Grant
Filed:
December 28, 2020
Date of Patent:
October 11, 2022
Assignee:
Temple University-Of The Commonwealth System of Higher Education
Inventors:
Samuel Alex Weprin, John Noel, Daniel D. Eun
Abstract: Systems and methods for reducing blood viscosity along a flow direction, suppressing turbulence in blood flow, and treating rouleaux are disclosed. One method includes applying a unidirectional magnetic field to a flow of blood in a direction parallel or antiparallel to a direction of the flow of blood, and maintaining the application of the unidirectional magnetic field to the flow of blood until a blood viscosity along the direction of the flow of blood is reduced and/or the turbulence in the blood flow is suppressed. One system includes an annular magnet sized to encircle a portion of a patient's body. The magnet is adapted to generate a unidirectional magnetic field in a region within the annular magnet. The unidirectional magnetic field has a strength sufficient to reduce the blood viscosity in the portion of the patient's body and/or suppress turbulence in the blood flow by a predetermined amount. The system will also break rouleaux for patients with rouleaux, but the process will take more time.
Type:
Grant
Filed:
November 1, 2017
Date of Patent:
August 9, 2022
Assignee:
Temple University of the Commonwealth System of Higher Education
Inventors:
Rongjia Tao, Hong Tang, Xiaojun Xu, Kazi M. Tawhid-Al-Islam, Enpeng Du
Abstract: The invention provides a novel ceramic-metal oxide-polymer composite material. A functionalized metal oxide nanolayer coating can be bonded between LICGCs and polymers/oligomers, which protects the LICGC from corrosion, has a low interfacial resistance to Li+ migration, and can be a SIC. Hybrid ceramic-polymer electrolytes were formed by engineering the interface between a LICGC and a polymer, polyethylene oxide (PEO), by sputter coating a 200 nm thick SiO2 layer onto a lithium ion conducting glass ceramic (LICGC) and silanating the SiO2 with a functionalized PEG in the presence of LiTFSI. A low interfacial resistance (Rinterfacial) was measured, the same as that obtained for a SiO2 interface soaked with liquid tetraglyme/LiTFSI. The pegylated SiO2 interface (unlike the tetraglyme/LiTFSI interface) protected the LICGC from corrosion by Li0 metal. The (PEG-LiTFSI)—SiO2-LICGC could be bonded with polyethylene oxide/LiTFSI.
Type:
Grant
Filed:
October 9, 2017
Date of Patent:
July 12, 2022
Assignee:
Temple University-Of The Commonwealth System of Higher Education
Inventors:
Stephanie Wunder, Mike Zdilla, Parameswara Rao Chinnam
Abstract: The present invention provides novel multi-functional (e.g., repelling biofilms, promoting formation of minerals, and having anti-infection properties) biocomposites and methods of use thereof. In various embodiments, the present invention also provides method for simultaneously treating biofilms, promoting mineralization, treating infection, or any combination thereof.
Type:
Application
Filed:
March 26, 2020
Publication date:
May 26, 2022
Applicant:
Temple University-Of The Commonwealth System of Higher Education
Abstract: The invention provides compositions and methods for the diagnosis, treatment, assessment, and characterization of hyperlipidemia-related diseases and disorders, including atherosclerosis, non-alcoholic fatty liver disease, obesity and diabetes mellitus in a subject in need thereof, based on the expression level of at least one miRNA that is associated with these diseases and disorders.
Type:
Grant
Filed:
May 21, 2019
Date of Patent:
May 17, 2022
Assignee:
Temple University-Of The Commonwealth System of Higher Education
Abstract: The present application provides compounds and methods of treating bacterial infection, including bacterial infection caused by P. acnes.
Type:
Grant
Filed:
May 17, 2018
Date of Patent:
March 22, 2022
Assignees:
The General Hospital Corporation, Rhode Island Hospital, A Lifespan-Partner, Temple University-Of The Commonwealth System of Higher Education
Inventors:
Frederick M. Ausubel, Wooseong Kim, Eleftherios Mylonakis, William M. Wuest
Abstract: Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided.
Type:
Grant
Filed:
January 30, 2015
Date of Patent:
February 1, 2022
Assignee:
TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Inventors:
Arthur M. Feldman, Douglas G. Tilley, Weizhong Zhu, Kamel Khalili, Walter J. Koch
Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.
Type:
Grant
Filed:
March 15, 2018
Date of Patent:
January 11, 2022
Assignee:
Temple University-Of the Commonwealth System of Higher Education
Inventors:
Benjamin E. Blass, Daniel J. Canney, Kevin M. Blattner
Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.
Type:
Grant
Filed:
December 12, 2019
Date of Patent:
December 7, 2021
Assignee:
Temple University-Of The Commonwealth System of Higher Education
Inventors:
Daniel J. Canney, Benjamin E. Blass, Rong Gao, Magid Abou-Gharbia
Abstract: The present invention includes novel polycationic amphiphilic compounds useful as antimicrobial agents. The present invention further includes methods useful for removing microorganisms and/or biofilm-embedded microorganisms from a surface. The present invention further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms and/or biofilm-embedded microorganisms on a surface.
Type:
Grant
Filed:
October 26, 2017
Date of Patent:
September 7, 2021
Assignees:
Temple University-Of The Commonwealth System of Higher Education, Villanova University
Abstract: Identification of BAG3 (Bcl2-associated anthanogene 3) genetic variants were associated with the prevalence non-ischemic or ischemic dilated cardiomyopathy (DCM) and DCM outcomes in individuals of African ancestry.
Type:
Application
Filed:
June 7, 2019
Publication date:
August 19, 2021
Applicant:
TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Abstract: Compositions and methods for the promotion of wound healing and tissue regeneration are described. The compositions and methods make use of water-soluble soy protein isolates (WSsoy), Fraction 5, Fraction 9, and/or bioactive peptide components of soy protein isolates. The invention also relates to the unexpected discovery that purified WSsoy forms gel-like matrices when suspended within certain concentration ranges in an aqueous environment. The compositions of the invention comprising WSsoy promote natural healing and have a low risk profile.
Type:
Grant
Filed:
July 21, 2016
Date of Patent:
August 3, 2021
Assignee:
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Inventors:
Peter I. Lelkes, Yah-El H. Har-el, Cezary Marcinkiewicz, Philip Lazarovici, Sogol Moaiyed Baharlou, Jonathan A. Gerstenhaber
Abstract: The present invention provides for the first time the identification of fetal neural exosomal biomarkers isolated from maternal plasma useful in diagnosing fetal neurodevelopmental outcomes. The invention also provides the identification of neonatal neural exosomal biomarkers isolated from neonatal plasma useful in diagnosing neonatal neurodevelopmental outcomes The present invention therefore provides methods, kits and systems for diagnosing fetal neurodevelopmental outcomes, by examining relevant proteins and RNA in fetal neural exosomes isolated from a maternal plasma and neonatal neural exosomes isolated from neonatal plasma.
Type:
Grant
Filed:
January 6, 2017
Date of Patent:
March 30, 2021
Assignee:
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of sigma-2 receptor activity.
Type:
Grant
Filed:
March 15, 2018
Date of Patent:
March 30, 2021
Assignee:
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Inventors:
Benjamin E. Blass, Daniel J. Canney, Kevin M. Blattner
Abstract: The present invention includes novel bridged bicycloalkyl-substituted aminothiazole compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.
Type:
Grant
Filed:
January 19, 2018
Date of Patent:
March 9, 2021
Assignee:
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Inventors:
Wayne C. Childers, Magid A. Abou-Gharbia, George C. Morton, Jean-Pierre J. Issa, Hanghang Zhang
Abstract: Methods of eliminating a retrovirus from a subject utilize nanoformulated anti-retroviral compounds and gene editing agents. Compositions comprise at least one anti-retroviral compounds, at least one gene-editing agent, or combinations thereof.
Type:
Application
Filed:
March 6, 2020
Publication date:
March 4, 2021
Applicants:
Temple University - of the Commonwealth System of Higher Education, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
Inventors:
Kamel Khalili, Howard E. Gendelman, Benson Edagwa
Abstract: In certain embodiments, this disclosure relates to methods of treating or preventing type 2 diabetes, pre-diabetes and conditions characterized by an increase in the levels of A1C, glucose, insulin, homeostasis model of assessment of insulin resistance HOMA-IR), oxidative stress in adipose tissue, and earbonvlation of GLUT4 comprising administering an effective amount of a compound of Formula I-III as described herein, to a subject in need thereof.
Type:
Application
Filed:
March 7, 2019
Publication date:
February 25, 2021
Applicant:
Temple University - Of The Commonwealth System Of Higher Education
Inventors:
Salim MERALI, Carlos A. BARRERO, Wayne E. CHILDERS, George C. MORTON
Abstract: Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided.
Type:
Application
Filed:
May 21, 2020
Publication date:
January 21, 2021
Applicant:
TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Inventors:
Arthur M. Feldman, Douglas G. Tilley, Weizhong Zhu, Kamel Khalili, Walter J. Koch
Abstract: The present invention provides homologous recombination vectors to insert transgenic DNA in cells. These vectors shorten the production time and allow for easy generation of genetically modified cells. The invention allows the user to test multiple tags and to generate homozygous modified cell line using the homologous recombination vector. The invention can be used to generate knockout cells, to generate cell lines with knockin genes, to generate cell lines for drug screening against any target, to create transgenic animals, or in gene therapy.
Type:
Grant
Filed:
September 12, 2019
Date of Patent:
January 5, 2021
Assignee:
Temple University-Of The Commonwealth System of Higher Education