Patents Assigned to TEMPO BIOSCIENCE, INC.
  • Biosensors for chloride ions
    Patent number: 10640766
    Abstract: This invention provides biosensors, cell models, and methods of their use for monitoring chloride ion, where the biosensors can include targeting domains, sensing domains and reporting domains. Biosensors can be introduced into cells reprogrammed to represent experimental or pathologic cells of interest, including as detectors of chloride ions, as TempoChloro™ accomplishes.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: May 5, 2020
    Assignee: TEMPO BIOSCIENCE, INC.
    Inventor: Angela Huang
  • Biosensors for cellular osmolarity
    Patent number: 10571480
    Abstract: This invention provides biosensors, cell models, and methods of their use for monitoring osmolarity. Biosensors can include targeting domains, sensing domains and reporting domains. Biosensors can be introduced into cells reprogrammed to represent experimental or pathologic cells of interest. Model cells expressing the biosensors can be contacted with putative bioactive agents to determine possible activities, including as detectors of which is pH changes, as TempoOsmo™ accomplishes.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: February 25, 2020
    Assignee: Tempo Bioscience, Inc.
    Inventor: Angela Huang
  • Human biosensors for heme binding
    Patent number: 9816928
    Abstract: This invention provides biosensors, cell models, and methods of their use for monitoring heme and oxygen. Biosensors can include targeting domains, sensing domains and reporting domains. Biosensors can be introduced into cells reprogrammed to represent experimental or pathologic cells of interest. Model cells expressing the biosensors can be contacted with putative bioactive agents to determine possible activities.
    Type: Grant
    Filed: November 26, 2016
    Date of Patent: November 14, 2017
    Assignee: Tempo Bioscience Inc.
    Inventor: Angela Huang
  • Human calcium binding domain biosensors
    Patent number: 9587230
    Abstract: This invention provides biosensors, cell models, and methods of their use for monitoring ionic or voltage responses to contact with bioactive agents. Biosensors can include targeting domains, sensing domains and reporting domains. Biosensors can be introduced into cells reprogrammed to represent experimental or pathologic cells of interest. Model cells expressing the biosensors can be contacted with putative bioactive agents to determine possible activities.
    Type: Grant
    Filed: August 26, 2014
    Date of Patent: March 7, 2017
    Assignee: TEMPO BIOSCIENCE, INC.
    Inventor: Angela L. Huang