Abstract: 4-Alkoxypyrrolo[2,1-f][1,2,4]triazine compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 4-alkoxypyrrolo[2,1-f][1,2,4]triazine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).
Type:
Grant
Filed:
June 23, 2023
Date of Patent:
September 8, 2026
Assignee:
TenaRx, Inc.
Inventors:
Gopi Kumar Mittapalli, Chi Ching Mak, Lewis Daniel Turner, Brian Joseph Hofilena, Ramkrishna Reddy Vakiti, Brian Walter Eastman, David Mark Wallace