Abstract: The present invention discloses composition comprising an open matrix network carrying pharmaceutically active cannabinoid substance, pharmaceutically acceptable water soluble or water dispersible carrier materials provided as discrete units of the suspension or emulsion in form of liquid units contained in pockets of suitable mould, solid units such as frozen units, gelled units or frozen discrete units, wherein the composition is in the form chosen from sublingual tablet, buccal tablet, and rapidly disintegrating tablet.