Abstract: Angiotensin (1-7) analogs are provided. Also provided are methods of making such analogs methods for using analogs as therapeutic compositions such as, for example, treatment cancer.
Type:
Grant
Filed:
September 16, 2016
Date of Patent:
November 10, 2020
Assignees:
WAKE FOREST UNIVERSITY HEALTH SCIENCES, TENSIVE CONTROLS, INC.
Inventors:
Patricia Gallagher, Ann Tallant, Daniel Yohannes, Kenneth A. Gruber
Abstract: Angiotensin (1-7) analogs are provided. Also provided are methods of making such analogs methods for using analogs as therapeutic compositions such as, for example, treatment cancer.
Type:
Application
Filed:
September 16, 2016
Publication date:
August 8, 2019
Applicants:
WAKE FOREST UNIVERSITY HEALTH SCIENCES, TENSIVE CONTROLS, INC.
Inventors:
PATRICIA GALLAGHER, ANN TALLANT, DANIEL YOHANNES, KENNETH A. GRUBER
Abstract: Compositions and methods are disclosed for a non-naturally occurring melanocortin ligand comprised of a melanocortin analog coupled to a degradation-resistant C-terminal extension and, optionally, an N-terminal extension, to produce a stable melanocortin ligand having diminished or abolished cardiovascular activity while retaining desired melanocortin regulatory activity.
Abstract: Compositions and methods are disclosed for a non-naturally occurring melanocortin ligand comprised of a melanocortin analog coupled to a degradation-resistant C-terminal extension and, optionally, an N-terminal extension, to produce a stable melanocortin ligand having diminished or abolished cardiovascular activity while retaining desired melanocortin regulatory activity.