Abstract: A device for indirect temperature regulation of the brain of a human via a nasal cavity thereof, the device comprising: a membrane having a membrane surface area, a length, a center point with respect to the length, a width, and a center point with respect to the width, said membrane adapted to be arranged in contact with a surface of the nasal cavity, said membrane defining a closed volume and having the shape of the nasal cavity such that when in use, it expands and conforms to the nasal cavity, a first catheter, a second catheter, and means for circulating said fluid into said volume via said first catheter and out of said volume via said second catheter.