Abstract: A touch panel structure is provided. The touch panel structure includes a sapphire substrate having a crystal axis, a crystal structure and a transmittance, wherein the crystal axis includes one selected from a group consisting of c-axis (0001), a-axis (1210), a-axis (1 120), a-axis (2110), a-axis (1120), a-axis (21 10), a-axis (1210), m-axis (1010), m-axis (1100), m-axis (0110), m-axis (1010), m-axis (1100), m-axis (0110), r-axis (1011), r-axis (1011), r-axis (0111), r-axis (011 1), r-axis (1101) and r-axis (1101), the crystal structure is a single-crystal structure, and the transmittance is one of percentages larger than and equal to 80%; and a sensing module including a first sensing layer directly disposed on the sapphire substrate.