Patents Assigned to Terumo BCT, Inc.
  • Publication number: 20220112967
    Abstract: Provided is a centrifuge cassette assembly (800) for separating a fluid and related method of manufacture. The cassette assembly includes a first chamber, a second chamber (308), a fluidic channel (808) creating a fluid connection between the first chamber and the second chamber, at least one molded insertion valve (600, 700) configured to control the flow of fluid in the fluidic channel and a heating element (802) for actuating the at least one molded valve. Further provided are Normally Open Valves (NOVs) (700) and Normally Closed Valves (NCVs) (600) which are capable of insertion into, and which control the fluid flow of, the centrifuge cassette assembly.
    Type: Application
    Filed: February 26, 2020
    Publication date: April 14, 2022
    Applicant: Terumo BCT, Inc.
    Inventors: Randy PEERY, James LADTKOW, Jesse JANZEN, Andrew GLOOR, Kevin KLIMEK
  • Publication number: 20210361849
    Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.
    Type: Application
    Filed: August 3, 2021
    Publication date: November 25, 2021
    Applicant: Terumo BCT, Inc.
    Inventors: Taylor POLODNA, Brian M. HOLMES
  • Publication number: 20210361850
    Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.
    Type: Application
    Filed: August 4, 2021
    Publication date: November 25, 2021
    Applicant: Terumo BCT, Inc.
    Inventors: Brian M. HOLMES, Thomas J. FELT, Taylor POLODNA
  • Publication number: 20210361848
    Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.
    Type: Application
    Filed: August 3, 2021
    Publication date: November 25, 2021
    Applicant: Terumo BCT, Inc.
    Inventors: Peter O'BRIEN, Brian M. HOLMES
  • Publication number: 20210361847
    Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.
    Type: Application
    Filed: August 3, 2021
    Publication date: November 25, 2021
    Applicant: Terumo BCT, Inc.
    Inventors: Thomas J. FELT, Dennis J. HLAVINKA, Brian M. HOLMES
  • Patent number: 11137206
    Abstract: Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma.
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: October 5, 2021
    Assignee: Terumo BCT, Inc.
    Inventors: Frank Corbin, III, Dennis J. Hlavinka, Rajesh Pareta, Mark E. Hillam
  • Patent number: 11110217
    Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: September 7, 2021
    Assignee: Terumo BCT, Inc.
    Inventors: Peter O'Brien, Brian M. Holmes
  • Patent number: 11104874
    Abstract: Embodiments provide for introducing a first fluid into a bioreactor and while introducing the first fluid into the bioreactor, circulating a second fluid with a reagent at a first flow rate through the bioreactor. The bioreactor may be maintained in a first orientation for a first period of time to allow at least a first portion of the reagent to coat the bioreactor. The second fluid may then be circulated at a second flow rate slower than the first flow rate to allow a second portion of the reagent to coat the bioreactor. Introduction of the first fluid may promote coating of the bioreactor by ultrafiltration. The introduction of the first fluid may be stopped. A third fluid may be circulated through the bioreactor to remove a portion of the reagent not coated on the bioreactor.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: August 31, 2021
    Assignee: Terumo BCT, Inc.
    Inventors: Nathan D. Frank, Brian J. Nankervis, Dennis J. Hlavinka, Thomas G. Dilorenzo
  • Patent number: 11103630
    Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: August 31, 2021
    Assignee: Terumo BCT, Inc
    Inventors: Brian M. Holmes, Thomas J. Felt, Taylor Polodna
  • Patent number: 11103629
    Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: August 31, 2021
    Assignee: Terumo BCT, Inc.
    Inventors: Taylor Polodna, Brian M. Holmes
  • Patent number: 11090425
    Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: August 17, 2021
    Assignee: Terumo BCT, Inc.
    Inventors: Thomas J. Felt, Dennis J. Hlavinka, Brian M. Holmes
  • Patent number: 11067336
    Abstract: Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma.
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: July 20, 2021
    Assignee: Terumo BCT, Inc.
    Inventors: Frank Corbin, III, Dennis J. Hlavinka, Rajesh Pareta, Mark E. Hillam
  • Patent number: 11013850
    Abstract: Embodiments are described that include systems and methods for separating components of a composite fluid, e.g., whole blood. Some embodiments provide for processing a composite fluid by subjecting a volume of the fluid to a first centripetal acceleration for an initial separation, followed by a second centripetal acceleration for a second separation.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: May 25, 2021
    Assignee: Terumo BCT, Inc.
    Inventors: Bruce W. Gibbs, Bruce Ellingboe, Jeffrey J. Blakeslee
  • Patent number: 11013851
    Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: May 25, 2021
    Assignee: Terumo BCT, Inc.
    Inventors: Brian M. Holmes, Thomas J. Felt, Peter O'Brien
  • Patent number: 11008547
    Abstract: Embodiments described herein generally relate to passively replacing media in a closed cell expansion system to reduce or prevent the dilution of chemical signaling used to inhibit signaling pathways that keep a cell population in the lag phase of cell growth. To prevent such dilution, active inlet fluid flow to the system may be halted. To replace fluid lost by the system, a bag containing media may be attached to the waste line in replacement of the waste or outlet bag connected thereto. By turning off one or more pumps, media from the replacement bag is added to the system at the rate of evaporation. Chemical signaling dilution may be prevented while conserving system resources. Enhancement of chemical signaling to reduce the lag phase of cell growth may further be accomplished by adding molecules, such as chemical-signaling proteins, from a direct source to the system.
    Type: Grant
    Filed: March 25, 2015
    Date of Patent: May 18, 2021
    Assignee: Terumo BCT, Inc.
    Inventor: Brian J. Nankervis
  • Patent number: 10976105
    Abstract: Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma.
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: April 13, 2021
    Assignee: Terumo BCT, Inc.
    Inventors: Frank Corbin, III, Dennis J. Hlavinka, Rajesh Pareta, Mark E. Hillam
  • Patent number: 10969171
    Abstract: Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma.
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: April 6, 2021
    Assignee: Terumo BCT, Inc.
    Inventors: Frank Corbin, III, Dennis J. Hlavinka, Rajesh Pareta, Mark E. Hillam
  • Publication number: 20210047602
    Abstract: Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. In further embodiments, the cells may include T cell subpopulations, including regulatory T cells (Tregs), helper, naïve, memory, or effector, for example.
    Type: Application
    Filed: November 2, 2020
    Publication date: February 18, 2021
    Applicant: Terumo BCT, Inc.
    Inventors: Boah VANG, Brian J. NANKERVIS, Mark E. JONES
  • Publication number: 20210024876
    Abstract: Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.
    Type: Application
    Filed: September 30, 2020
    Publication date: January 28, 2021
    Applicant: Terumo BCT, Inc.
    Inventors: Edward Allan STANTON, IV, Glen Delbert ANTWILER, Patrick J. HOWLEY, Michael E. KINZIE, Jon A. DODD, Casey V. MEDINA
  • Patent number: 10870827
    Abstract: Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: December 22, 2020
    Assignee: Terumo BCT, Inc.
    Inventors: Edward Allan Stanton, IV, Glen Delbert Antwiler, Patrick J. Howley, Michael E. Kinzie, Jon A. Dodd, Casey V. Medina