Abstract: Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.
Type:
Grant
Filed:
March 2, 2018
Date of Patent:
December 4, 2018
Assignee:
Terumo Corporation
Inventors:
Gregory M. Cruise, Gloria Hincapie, Clayton Harris
Abstract: Described herein are apparatus, compositions, systems and methods for occluding vascular structures and vascular malformations with radiopaque hydrogel filaments. The filaments can contain no support members and can be CT and MR compatible. Methods of forming such filaments are also disclosed.
Type:
Grant
Filed:
April 3, 2015
Date of Patent:
November 13, 2018
Assignee:
Terumo Corporation
Inventors:
Michael Constant, Edward Michael Keeley, Joshua Garretson, Gregory M. Cruise, Wendy Graczyk
Abstract: Polymers are described herein comprising: a reaction product of a prepolymer solution including at least one macromer, at least one flexomer, and at least one visualization agent. Methods of making and using these polymers are also described.
Type:
Grant
Filed:
April 3, 2015
Date of Patent:
October 9, 2018
Assignee:
Terumo Corporation
Inventors:
Michael Constant, Gregory M. Cruise, Samuel Chen
Abstract: A drive mechanism for a drug delivery device having a rotationally fixed plunger rod driven by a lead screw. The lead screw engages a free lock which is coupled to a release knob. A dose setting dial cooperates with an inner cylinder using a clutch to establish the axial movement of the plunger rod during dose setting and dispensing.
Type:
Grant
Filed:
September 3, 2015
Date of Patent:
August 28, 2018
Assignees:
Terumo Corporation, Sanofi-Aventis Deutschland GMBH
Abstract: Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.
Type:
Grant
Filed:
June 22, 2017
Date of Patent:
April 10, 2018
Assignee:
Terumo Corporation
Inventors:
Gregory M. Cruise, Gloria Hincapie, Clayton Harris
Abstract: Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.
Type:
Grant
Filed:
December 5, 2016
Date of Patent:
October 31, 2017
Assignee:
Terumo Corporation
Inventors:
Gregory M. Cruise, Gloria Hincapie, Clayton Harris
Abstract: Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.
Type:
Grant
Filed:
September 19, 2014
Date of Patent:
January 17, 2017
Assignee:
Terumo Corporation
Inventors:
Gregory M. Cruise, Gloria Hincapie, Clayton Harris
Abstract: Described herein are apparatus, compositions, systems and associated methods to occlude structures and malformations of the vasculature with radiopaque hydrogel filaments with delayed controlled rates of expansion. Further described is a device for implantation in an animal comprising a difunctional, low molecular weight ethylenically unsaturated shapeable macromer; an ethylenically unsaturated monomer; and a radiopaque element, wherein said device contains no support members. Methods of forming such devices are also disclosed.
Type:
Grant
Filed:
April 18, 2012
Date of Patent:
October 4, 2016
Assignee:
Terumo Corporation
Inventors:
Michael Constant, Josh Garretson, Gregory M. Cruise
Abstract: An internal tissue including a lesion region in the human body is modeled as a three-dimensional model. By reconstructing thickness or flexibility of a lumen wall portion including the lesion region and making it possible to confirm a motion of the lumen wall or a flow of fluid in the inside of the lumen wall, a state of the lesion region in the lumen can be confirmed clearly by visual inspection or the like. As a result, the diagnosis in the lumen can be made easier.
Abstract: A drive mechanism for a drug delivery device having a rotationally fixed plunger rod driven by a lead screw. The lead screw engages a free lock which is coupled to a release knob. A dose setting dial cooperates with an inner cylinder using a clutch to establish the axial movement of the plunger rod during dose setting and dispensing.
Type:
Grant
Filed:
August 20, 2008
Date of Patent:
October 13, 2015
Assignees:
TERUMO CORPORATION, SANOFI-AVENTIS DEUTSCHLAND GMBH
Abstract: This invention relates to a dose display mechanism for a drug delivery device that allows the user to select multiple doses of an injectable drug and for the dispensing of the set dosage of the drug and applying said drug to a patient, preferably by injection.
Type:
Application
Filed:
May 17, 2012
Publication date:
September 13, 2012
Applicants:
TERUMO CORPORATION, SANOFI-AVENTIS DEUTSCHLAND GMBH
Abstract: This invention relates to a cap for drug delivery devices, in particular of the injector-type comprising a needle and a needle cover, wherein said cap is suitable as a needle safety tool, by comprising a needle cover retaining portion. In particular, the present invention relates to such devices, which are handled by the patients themselves.
Type:
Grant
Filed:
March 16, 2007
Date of Patent:
November 15, 2011
Assignees:
Terumo Corporation, Sanofi-Aventis Deutschland GmbH
Abstract: An internal tissue including a lesion region in the human body is modeled as a three-dimensional model. By reconstructing thickness or flexibility of a lumen wall portion including the lesion region and making it possible to confirm a motion of the lumen wall or a flow of fluid in the inside of the lumen wall, a state of the lesion region in the lumen can be confirmed clearly by visual inspection or the like. As a result, the diagnosis in the lumen can be made easier.
Abstract: There is described an artificial blood vessel for use in a region of a living body which needs to be repeatedly pierced with a needle. The artificial blood vessel includes a main section having a vessel wall which includes a laminated assembly comprising an inner layer, an outer layer, and an intermediate layer positioned therebetween, and a pair of anastomotic sections disposed on the respective opposite ends of the main section. Each of the anastomotic sections has an intermediate layer thinner than the intermediate layer of the main section or is free of an intermediate layer, so that the anastomotic section as a vessel wall thinner than the main section.
Abstract: A blood vessel in a patient is severed by inserting a shaft through an incision in the patient, the shaft carrying first and second clamps. The first and second clamps are closed against the vessel in closely adjacent relationship to one another. Thereafter, the clamps are moved in generally opposing directions to sever the vessel at a location between the clamps. Each clamp carries a cauterizing pad for cauterizing the severed ends of the vessel.
Abstract: An endoscopic apparatus for dissecting a blood vessel includes a endoscopic barrel having a plurality of lumens, one of the lumens being dimensioned for receiving an endoscope, a handle disposed at a proximal end of the endoscopic barrel, at least two fingers having distally curved ends for dissecting and cauterizing the desired blood vessel, and a displaceable cone portion disposed over a distal end of the endoscopic barrel. The cone portion has a first position concealing the at least two fingers and a second, extended position exposing the at least two fingers. A control rod extends between the handle and each of the fingers such that movement of the control mechanism between a first position and a second position produces a predetermined movement of the respective finger.
Type:
Grant
Filed:
March 1, 2004
Date of Patent:
July 7, 2009
Assignees:
Terumo Corporation, Olympus Medical Systems Corp.
Abstract: An endoscopic apparatus for harvesting a desired blood vessel including an endoscopic barrel having at least two lumens, one of the lumens dimensioned for receiving an endoscope, a handle disposed at a proximal end of the endoscopic barrel, a cone portion disposed over a distal end of the endoscopic barrel, and at least one manipulator fork extendable from the cone portion for dissecting the desired blood vessel from connective tissue.
Abstract: This invention relates to a drive mechanism for a drug delivery device, drug delivery devices comprising the drive mechanism of the invention and a method of assembling such drug delivery devices, which allow the user to select multiple doses of an injectable drug and to dispense the set dose of the drug.
Type:
Application
Filed:
August 20, 2008
Publication date:
December 18, 2008
Applicants:
sanofi-aventis Deutschland GmbH, Terumo Corporation