Patents Assigned to TERVEYDEN JA HYVINVOINNIN LAITOS
  • Patent number: 9708609
    Abstract: The deficiency of Usf1 confers a remarkable number of clinically relevant beneficial metabolic effects in mice via activation of brown adipose tissue. The Usf1 deficient mice have high serum HDL-cholesterol and low triglyceride levels, a beneficial lipid profile opposite to that of human metabolic syndrome. The elevated HDL-C is associated with enhanced cholesterol efflux, and low triglycerides with decreased hepatic VLDL production and elevated triglyceride clearance. Despite their elevated food intake and lower physical activity, the Usf1 deficient mice are protected against diet-induced obesity. Their concomitant increase in energy expenditure is related to the activation of brown adipose tissue. The protective effects of Usf1 deficiency against obesity, insulin resistance, fatty liver, dyslipidemia, vascular inflammation, and atherosclerosis coupled with brown adipose tissue activation are demonstrated. Inhibition or silencing of USF1 is suggested as a therapeutic target to treat various human diseases.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: July 18, 2017
    Assignee: Terveyden ja hyvinvoinnin laitos (THL)
    Inventors: Pirkka-Pekka Laurila, Jarkko Soronen, Matti Jauhiainen, Anu Jalanko
  • Publication number: 20110275085
    Abstract: The present invention relates to the field of diagnostics, especially to the detection of autoimmune diseases such as rheumatoid arthritis. Particularly, the invention provides a method for detecting the presence or absence of rheumatoid arthritis, or of a predisposition therefore or for monitoring rheumatoid arthritis in a subject using expression data of target genes related to immune system and tools of bioinformatics.
    Type: Application
    Filed: December 1, 2009
    Publication date: November 10, 2011
    Applicant: TERVEYDEN JA HYVINVOINNIN LAITOS
    Inventors: Harri Salo, Jarno Honkanen, Outi Vaarala