Patents Assigned to Tethys Bioscience, Inc.
  • Patent number: 8409816
    Abstract: The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify individuals at risk of developing Diabetes.
    Type: Grant
    Filed: October 5, 2011
    Date of Patent: April 2, 2013
    Assignee: Tethys Bioscience, Inc.
    Inventors: Michael S. Urdea, Michael P. McKenna, Patrick A. Arensdorf
  • Patent number: 8357497
    Abstract: Disclosed are systems and methods for developing diagnostic tests (e.g., detection, screening, monitoring, and prognostic tests) based on biomarker information from legacy clinical sample sets, for which only small sample volumes (e.g., about 0.05 to about 1.0 mL or less per sample) are typically available. For example, biomarkers (e.g., about 10, 50, 100, 150, 200, 300, or more) may be detected in the clinical samples through the use of single molecule detection and each biomarker may be detected in an assay that includes about 1 ?L or less of a legacy clinical sample.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: January 22, 2013
    Assignee: Tethys Bioscience, Inc.
    Inventors: Michael S. Urdea, Michael P. McKenna
  • Patent number: 8232065
    Abstract: Disclosed are systems and methods for developing diagnostic tests (e.g., detection, screening, monitoring, and prognostic tests) based on biomarker information from legacy clinical sample sets, for which only small sample volumes (e.g., about 0.05 to about 1.0 mL or less per sample) are typically available. For example, biomarkers (e.g., about 10, 50, 100, 150, 200, 300, or more) may be detected in the clinical samples through the use of single molecule detection and each biomarker may be detected in an assay that includes about 1 ?L or less of a legacy clinical sample.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: July 31, 2012
    Assignee: Tethys Bioscience, Inc.
    Inventors: Michael S. Urdea, Michael P. McKenna
  • Patent number: 8119358
    Abstract: The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify individuals at risk of developing Diabetes.
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: February 21, 2012
    Assignee: Tethys Bioscience, Inc.
    Inventors: Michael S. Urdea, Michael P. McKenna, Patrick A. Arensdorf
  • Patent number: 8097425
    Abstract: The invention provides methods, compositions, and kits for multiplex fractionation of proteins in a sample. Protein-binding molecules, such as small epitope antibodies or small epitope aptamers, are used for multiplex fractionation of proteins in a protein containing sample. Detection of fractionated proteins may be used for characterization of proteins in a sample in applications such as expression profiling, identification and/or quantification of proteins in a sample, and identification or detection of biomarkers.
    Type: Grant
    Filed: March 12, 2007
    Date of Patent: January 17, 2012
    Assignee: Tethys Bioscience, Inc.
    Inventors: Michael S. Urdea, Michael P. McKenna, Scott Eastman
  • Publication number: 20100197028
    Abstract: Novel methods for assessing the state of a diabetic condition of a subject are described, comprising determining the amount of a metabolite in a sample from a body fluid or tissue of the subject. The methods may be used, for example, in diagnosing and monitoring insulin resistance, prediabetes, or the response to a drug which alters a diabetic condition.
    Type: Application
    Filed: February 22, 2008
    Publication date: August 5, 2010
    Applicant: Tethys Bioscience, Inc.
    Inventors: Steven M. Watkins, Michelle M. Wiest
  • Patent number: 7723050
    Abstract: The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify individuals at risk of developing Diabetes.
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: May 25, 2010
    Assignee: Tethys Bioscience, Inc.
    Inventors: Michael S. Urdea, Michael P. McKenna, Patrick A. Arensdorf
  • Publication number: 20090012716
    Abstract: The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify individuals at risk of developing Diabetes.
    Type: Application
    Filed: April 18, 2008
    Publication date: January 8, 2009
    Applicant: Tethys Bioscience, Inc.
    Inventors: Michael S. Urdea, Michael P. McKenna, Patrick A. Arensdorf
  • Publication number: 20070218519
    Abstract: Disclosed are methods of identifying subjects with Diabetes or a pre-diabetic condition, methods of identifying subjects at risk for developing Diabetes or a pre-diabetic condition, methods of differentially diagnosing diseases associated with Diabetes or a pre-diabetic condition from other diseases or within sub-classifications of Diabetes, methods of evaluating the risk of progression to Diabetes or a pre-diabetic condition in patients, methods of evaluating the effectiveness of treatments in subjects with Diabetes or a pre-diabetic condition, and methods of selecting therapies for treating Diabetes or a pre-diabetic condition, using biomarkers.
    Type: Application
    Filed: October 11, 2006
    Publication date: September 20, 2007
    Applicant: Tethys Bioscience, Inc.
    Inventors: Mickey Urdea, Michael McKenna, Patrick Arensdorf
  • Publication number: 20070042431
    Abstract: The present invention relates generally to methods for reducing the complexity of a sample. More specifically, the present invention relates to proteomics, the measurement of the protein levels in biological samples, and analysis of proteins in a sample using antibodies that recognize small epitopes.
    Type: Application
    Filed: October 23, 2006
    Publication date: February 22, 2007
    Applicant: Tethys Bioscience, Inc.
    Inventors: Michael Urdea, Gregory Landes, Gregory Went