Abstract: The present invention is directed to a [1,3]thiazin-2-amine compound, an application and a pharmaceutical composition, belongs to the field of BACE inhibitors. The [1,3]thiazin-2-amine compound is a compound represented by formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof. The compound has a good inhibitory effect on BACE and can be used in preparing a medicament for treating a neurodegenerative disease, such as Alzheimer's disease.
Type:
Grant
Filed:
December 14, 2017
Date of Patent:
January 12, 2021
Assignee:
TETRANOV PHARMACEUTICAL CO., LTD.
Inventors:
Yusheng Wu, Apeng Liang, Chengshan Niu, Yang Geng, Jingya Li
Abstract: The present invention is directed to a [1,3]thiazin-2-amine compound, an application and a pharmaceutical composition, belongs to the field of BACE inhibitors. The [1,3]thiazin-2-amine compound is a compound represented by formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof. The compound has a good inhibitory effect on BACE and can be used in preparing a medicament for treating a neurodegenerative disease, such as Alzheimer's disease.
Type:
Application
Filed:
December 14, 2017
Publication date:
October 31, 2019
Applicant:
TETRANOV PHARMACEUTICAL CO., LTD.
Inventors:
Yusheng WU, Apeng LIANG, Chengshan NIU, Yang GENG, Jingya LI