Abstract: Methods for cancer treatment include administering to a cancer patient an anti-CD38 antibody-attenuated human IFN alpha-2b construct and lenalidomide or pomalidomide. Tumors that may be treated according to these methods include tumors which comprise CD-38 expressing tumor cells, including B-cell lymphoma, multiple myeloma, non-Hodgkin's lymphoma, chronic myelogenous leukemia, chronic lymphocytic leukemia, and acute lymphocytic leukemia.
Type:
Grant
Filed:
January 31, 2017
Date of Patent:
March 19, 2019
Assignee:
TEVA PHARMACEUTICALS PTY LTD
Inventors:
Sarah L. Pogue, David S. Wilson, Anthony Gerard Doyle, Collette Jane Behrens