Patents Assigned to Teva Sante
  • Process for the preparation of and crystalline forms of optical enantiomers of modafinil
    Patent number: 9382200
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 8.54, 4.56, and 3.78 ?, and a process for the preparation thereof.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: July 5, 2016
    Assignee: Teva Sante
    Inventors: Olivier Neckebrock, Laurent Courvoisier, Stéphanie Graf, Gilles Serrure, Gérard Francois Coquerel, Sébastien Rose, Christine Besselievre, Franck Patrick Mallet, Adriaan Jan Van Langevelde
  • Process for the preparation of and crystalline forms of optical enantiomers of modafinil
    Patent number: 8975442
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 14.14, 10.66, 7.80 and 4.02 ?, and a process for the preparation thereof.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: March 10, 2015
    Assignee: Teva Sante
    Inventors: Pierre Leproust, Olivier Neckebrock
  • Method for purifying a fused pyrrolocarbazole derivative
    Patent number: 8884014
    Abstract: The present invention relates a method for purifying a fused pyrrolocarbazole compound known as 11-isobutyl-2-methyl-8-(2-pyrimidinylamino)-2,5,6,11,12,13-hexahydro-4Hindazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one using an acid complex thereof. The present invention also relates to a crystalline form of the acid complex.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: November 11, 2014
    Assignees: Cephalon, Inc., Teva Sante
    Inventors: Shawn P. Allwein, Arnaud Grandeury, Guy Piacenza, Sebastien Rose
  • Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
    Patent number: 8759583
    Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein n, Y, R1, R1a, R2 and R2a are as defined in claim 1.
    Type: Grant
    Filed: November 1, 2012
    Date of Patent: June 24, 2014
    Assignee: Teva Sante
    Inventors: Laurent Courvoisier, Gerard Duret, Stephanie Graf, Laurence Prat-Lacondemine, Francois Rebiere, Nicolas Sabourault
  • Process for the preparation of and crystalline forms of optical enantiomers of modafinil
    Patent number: 8729305
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 14.14, 10.66, 7.80 and 4.02 ?, and a process for the preparation thereof.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: May 20, 2014
    Assignee: Teva Sante
    Inventors: Pierre Leproust, Olivier Neckebrock
  • Substituted phenoxypropylcycloamine derivatives as histamine-3 (H) receptor ligands
    Patent number: 8648067
    Abstract: The present invention provides compounds of formula I: their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceutical compositions thereof.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: February 11, 2014
    Assignees: Cephalon, Inc., Teva Sante
    Inventors: Edward R. Bacon, Thomas R. Bailey, Sankar Chatterjee, Derek D. Dunn, Greg A. Hostetler, Robert L. Hudkins, Brigitte Lesur, Babu G. Sundar, Allison L. Zulli, Christophe Yue
  • PROCESS FOR THE PREPARATION OF AND CRYSTALLINE FORMS OF OPTICAL ENANTIOMERS OF MODAFINIL
    Publication number: 20140031589
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 14.14, 10.66, 7.80 and 4.02 ?, and a process for the preparation thereof.
    Type: Application
    Filed: August 28, 2013
    Publication date: January 30, 2014
    Applicant: Teva Sante
    Inventors: Pierre Leproust, Olivier Neckebrock
  • Modafinil oral lyophilizate
    Patent number: 8563014
    Abstract: The invention concerns an oral lyophilizate comprising modafinil particles having a median diameter of about 10 to about 1000 ?m in association with an appropriate amount of at least one excipient selected from the group consisting of fatty acid esters of glycerol, cyclic oligosaccharides, sweeteners or mixtures thereof.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: October 22, 2013
    Assignee: Teva Sante
    Inventors: Thanh-Tam Nguyen, Joëlle Leyder
  • Regioselective reduction of fused pyrrolocarbazoles-5,7-diones
    Patent number: 8410267
    Abstract: The present invention relates to a method for regioselectively reducing the maleimide compounds of formula (I). The invention also relates to C7 hydroxy lactam regioisomers of formula (II) obtainable by this method and their use for the preparation of lactams of formula (III) which are particularly useful as intermediate for the synthesis of fused pyrrolocarbazoles.
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: April 2, 2013
    Assignee: Teva Sante
    Inventor: Laurence Prat-Lacondemine