Abstract: Compositions and methods for inhibiting and/or sensitizing or re-sensitizing a parasite to an antiparasitic drug are provided. The compositions can comprise a rifamycin derivative or a pharmaceutically acceptable salt, hydrate, or prodrug thereof in an amount and formulation sufficient to inhibit or induce drug-sensitization in a parasite. The methods can comprise administering a rifamycin derivative or a pharmaceutically acceptable salt, hydrate, or prodrug thereof to a parasite in an amount and formulation sufficient to inhibit or induce drug-sensitization in the parasite.
Type:
Grant
Filed:
August 18, 2016
Date of Patent:
March 12, 2019
Assignee:
The Texas A&M University System
Inventors:
James C. Sacchettini, Matthew W. Miller, Deeann Wallis, Nian E. Zhou, Theresa W. Fossum
Abstract: A hydrogel condom containing an antioxidant can provide increased sexual pleasure, thus improving usage and resulting in prevention of disease and prevention of unwanted pregnancies.
Abstract: The present invention provides methods for development of a virulent bacteriophage-based treatment for the control of plant diseases caused by Xylella fastidiosa. The invention further provides methods of isolating and propagating bacteriophage virulent to X. fastidiosa in a Xanthomonas bacterial host and for treating or reducing symptoms of X. fastidiosa infection in a plant. The invention further provides methods of isolating and propagating bacteriophage virulent to Xanthomonas axonopodis pv. citri and for treating or reducing symptoms of Xanthomonas axonopodis pv. citri infection in a plant.
Type:
Grant
Filed:
June 6, 2016
Date of Patent:
February 26, 2019
Assignee:
The Texas A&M University System
Inventors:
Carlos F. Gonzalez, Stephen J. Ahern, Mayukh Das, Ryland F. Young, III, Tushar Suvra Bhowmick
Abstract: The present disclosure relates to systems and methods for dehumidifying air by establishing a humidity gradient across a water selective permeable membrane in a dehumidification unit. Water vapor from relatively humid atmospheric air entering the dehumidification unit is extracted by the dehumidification unit without substantial condensation into a low pressure water vapor chamber operating at a partial pressure of water vapor lower than the partial pressure of water vapor in the relatively humid atmospheric air. For example, water vapor is extracted through a water permeable membrane of the dehumidification unit into the low pressure water vapor chamber. As such, the air exiting the dehumidification unit is less humid than the air entering the dehumidification unit. The low pressure water vapor extracted from the air is subsequently condensed and removed from the system at ambient conditions.
Abstract: A method and system for decoding low density parity check (“LDPC”) codes. A method and system for decoding low density parity check (“LDPC”) codes. An LDPC code decoder includes decoding circuitry configured to process blocks of an LDPC matrix. The decoding circuitry includes a control unit that controls processing by the decoding circuitry. The control unit is configured to cause the decoding circuitry to process blocks of a layer of the LDPC matrix out of order.
Abstract: The present disclosure relates, in some embodiments, to compositions, organisms, systems, and methods for expressing a gene product in a plant using a expression control sequence (ECS) operable in monocots and/or dicots. For example, (i) an isolated nucleic acid may comprise an ECS (e.g., a sugarcane bacilliform virus promoter) and, optionally, an exogenous nucleic acid (ExNA) operably linked to the ECS; (ii) an expression vector may comprise an ECS; an ExNA; and, optionally, a 3? termination sequence, wherein the ECS has promoter activity sufficient to express the ExNA in at least one monocot and at least one dicot; (iii) a microorganism, plant cell, or plant may comprise an isolated nucleic acid; (iv) a method for constitutively expressing an ExNA in a plant (e.g.
Abstract: A tire has a coating with a quadlayer or multiple quadlayers, and a method produces the same. In an embodiment, the method for coating a rubber substrate includes exposing the rubber substrate to a first cationic solution to produce a first cationic layer on the rubber substrate. The method also includes exposing the first cationic layer to a first anionic solution to produce a first anionic layer on the first cationic layer. In addition, the method includes exposing the first anionic layer to a second cationic solution to produce a second cationic layer on the first anionic layer. The method further includes exposing the second cationic layer to a second anionic solution to produce a second anionic layer on the second cationic layer. A quadlayer includes the first cationic layer, the first anionic layer, the second cationic layer, and the second anionic layer. The coating includes the quadlayer.
Type:
Grant
Filed:
December 28, 2012
Date of Patent:
February 5, 2019
Assignees:
Compagnie Generale des Etablissements Michelin, The Texas A&M University System
Inventors:
Jaime C. Grunlan, Morgan A. Priolo, Brian R. Bergman, John J. McHugh
Abstract: The present invention provides new compositions and methods for treating and/or reversing organophosphate intoxication, manifested by both cholinergic and non-cholinergic crisis, in a mammal resulting from exposure to organophosphate compounds. The neurosteroidal compounds of this invention are those having the general structural formula of pregnane, androstane, 19-norandrostanes, and norpregnane with further moieties as defined herein. These compounds include, but are not limited to, ganaxolone, pregnanolone, and androstanediol and their analogs, salts and prodrugs. The present invention further relates to combining a therapeutically effective amount of a neurosteroidal compound with a standard organophosphate antidote (e.g. atropine, pralidoxime). The data suggests that neurosteroids are effective or more effective than benzodiazepines, whether given earlier or later than 40-min (up to several hours) after organophosphate compound exposure.
Abstract: A method includes coating a substrate to provide a flame resistant substrate. In an embodiment, the method includes preparing an aqueous solution. The aqueous solution comprises a phosphate material, a cationic material, and a water. The method further includes exposing the substrate to the aqueous solution to produce a coating on the substrate. The coating includes the cationic material and the phosphate material. The method also includes exposing the coating on the substrate to a melamine solution.
Type:
Grant
Filed:
January 28, 2016
Date of Patent:
December 11, 2018
Assignee:
The Texas A&M University System
Inventors:
Jaime C. Grunlan, Marcus Leistner, Merid M. Haile
Abstract: Metals across all industries demand anti-corrosion surface treatments and drive a continual need for high-performing and low-cost coatings. Ordered thin films comprising aligned inorganic platelets dispersed in a polyelectrolyte polymer matrix provide a new class of transparent conformal barrier coatings for protection in corrosive atmospheres. For example, films assembled via layer-by-layer deposition, as thin as 90 nm, are shown to reduce copper corrosion rates by >1000× in an aggressive H2S atmosphere. These coatings can provide high-performing anti-corrosion treatment alternatives to costlier, more toxic, and less scalable thin films, such as graphene, hexavalent chromium, or atomic layer deposited metal oxides.
Type:
Grant
Filed:
June 14, 2018
Date of Patent:
December 11, 2018
Assignees:
National Technology & Engineering Solutions of Sandia, LLC, The Texas A&M University System
Inventors:
Eric John Schindelholz, Erik David Spoerke, Neil R. Sorensen, Jaime C. Grunlan
Abstract: Methods and systems for reducing the concentration of selenocyanate in water. In the methods and systems, water containing selenocyanate is treated an oxidant to provide oxidant-treated water, which is then contacted with a zero-valent iron treatment system comprising (a) a reactive solid comprising zero-valent iron and one or more iron oxide minerals in contact therewith and (b) ferrous iron.
Abstract: Methods and systems for reducing the concentration of selenium species in water, particularly water containing recalcitrant selenium species. In the methods and systems, water containing one or more selenium species is treated with permanganate to provide permanganate-treated water, which is then contacted with a zero-valent iron treatment system comprising (a) a reactive solid comprising zero-valent iron and one or more iron oxide minerals in contact therewith and (b) ferrous iron.
Abstract: The present invention provides methods of producing biological products or increasing production of such products through expression in a plant of a bacterial or plant glycolate catabolic cycle gene, such as glycolate dehydrogenease (GDH), glycolate oxidase (GO), or malate synthase (MS) in combination with a plant gene, such as farnesyl diphosphate synthase (FPS), squalene synthase (SQS), or PLAS. Also provided are plants, plants parts and compositions produced through methods of the present invention. The invention leads to two to five fold increase of end product yield.
Type:
Grant
Filed:
February 28, 2014
Date of Patent:
October 23, 2018
Assignees:
The Texas A&M University System, The University of Illinois at Urbana Champaign, University of Kentucky
Inventors:
Shuhua (Joshua) Yuan, Donald Ort, Joseph Chappell, Xinguang Zhu, Hong Ma, Yong Kyoung Kim
Abstract: The present disclosure relates, in some embodiments, to materials, systems, organisms, and methods for enhancing abiotic stress tolerance (e.g., cold, salinity, drought, heat, wind) and/or enhancing biomass in plants. For example, enhancing abiotic stress tolerance may be achieved in plants having Arabidopsis thaliana BCL-2-associated athanogene 4 (AtBAG4) nucleic acids and/or polypeptides, Caenorhabditis elegans Ced-9 nucleic acids and/or polypeptides, and/or human Bcl-2-161 nucleic acids and/or polypeptides.
Type:
Grant
Filed:
March 14, 2014
Date of Patent:
October 23, 2018
Assignee:
The Texas A&M University System
Inventors:
Martin B. Dickman, T. Erik Mirkov, Getu Beyene, Mayra Faion-Molina, Marco David Molina Risco
Abstract: The present invention encompasses methods and compositions for treating an ocular disease, disorder or condition in a mammal. The invention includes a population of mesenchymal stromal cells that possess anti-inflammatory, anti-apoptotic, immune modulatory and anti-tumorigenic properties. The invention includes administration of TSG-6, STC-1, or a combination thereof to the ocular as a treatment for an ocular disease, disorder or condition in a mammal.
Type:
Grant
Filed:
June 26, 2017
Date of Patent:
October 23, 2018
Assignees:
The Texas A&M University System, Temple Therapeutics, Inc.
Inventors:
Darwin J. Prockop, Joo Youn Oh, Barry Berkowitz, Gavin W. Roddy, Robert Rosa
Abstract: A method includes coating a substrate to provide a flame resistant substrate. In an embodiment, the method includes preparing a solution. The solution includes an anionic material, a cationic material, and water. The method further includes exposing the substrate to the solution to produce a coating on the substrate. The coating has cationic material and anionic material.
Abstract: Disclosed is a new variety of Prunus persica named ‘Fire Zest One’. This new fresh market variety, which requires approximately 500-550 chilling units of dormancy, is considered to be a peach tree of early season maturity, which ripens in early May in the medium chill zone of Texas and produces non-melting, yellow fleshed fruit that are very firm, attractively colored, and suitable for both local and long-distance shipping.
Abstract: A new and distinct cultivar of Oenothera drummondii identified as TX-12-5 characterized by 1) a propensity for free flowering (numerous flowers over an extended time and range of photoperiods), 2) a low spreading growth habit (typically less than 30 cm tall) with a dense canopy of foliage, 3) a grey-green shade of foliage compared to the green of most of the species, and 4) consistently bright yellow flowers.
Abstract: Disclosed is a new variety of Prunus persica named ‘SMOOTH DELIGHT THREE’. This new variety, which requires approximately 500 chilling units of dormancy, is considered to be a nectarine tree of early season maturity, which ripens in late May to early June in the medium chill zone of Texas and produces white fleshed fruit that are very firm, attractively colored, and suitable for both local and long-distance shipping.