Abstract: Disclosed is a method to enhance the reach of coiled tubing in the lateral section of a wellbore. The application of this method may enhance the use of coiled tubing in drilling very deep flowing wells. Similarly, the method may be applied in increasing the reach of the tubing for other coiled tubing well intervention applications. The method involves the use of downhole motor assemblies, stabilizers, and dynamic torque arrestors to rotate coiled-tubing string.

Abstract: A method includes coating a substrate to provide a flame resistant substrate. In an embodiment, the method includes exposing the substrate to a cationic solution to produce a cationic layer deposited on the substrate. The cationic solution comprises cationic materials. The cationic materials comprise a polymer, a colloidal particle, a nanoparticle, a nitrogen-rich molecule, or any combinations thereof. The method further includes exposing the cationic layer to an anionic solution to produce an anionic layer deposited on the cationic layer to produce a layer comprising the anionic layer and the cationic layer. The anionic solution comprises a layerable material.

Abstract: The disclosure provides rifamycin and rifamycin derivative compositions, including rifabutin and rifabutin derivative compositions able to cause drug-sensitization in a cancer cell or inhibition of a cancer cell. The disclosure also provides methods of administering such compositions to cancer cells to sensitize them to drugs, such as chemotherapeutics, or directly inhibit them. The disclosure also provides methods of administering such compositions to increase reactive oxygen species (ROS), particularly superoxides, in cancer cells. The disclosure further provides methods of determining whether a cancer will respond to chemotherapeutics and whether to administer rifamycin or a rifamycin derivative based on ROS levels in cancer cells of a patient.

Abstract: The AC portion of the input of the ultra-sparse partial resonant power converter contains three pairs of forward-conducting-bidirectional-blocking switches connected in a first direction, and two pairs of forward-conducting-forward-blocking devices connected in a second direction to the three pairs of forward-conducting-bidirectional-blocking switches. The second direction is opposite to the first direction. The AC portion of the output of the ultra-sparse partial resonant power converter contains three pairs of forward-conducting-bidirectional-blocking switches connected in a first direction, and two pairs of forward-conducting-reverse-blocking devices connected in a second direction to the three pairs of forward-conducting-bidirectional-blocking switches. The forward-conducting-reverse-blocking devices can be switches or diodes.

Abstract: A method includes coating a substrate to provide a flame resistant substrate. In an embodiment, the method includes exposing the substrate to a cationic solution to produce a cationic layer deposited on the substrate. The cationic solution comprises cationic materials. The cationic materials comprise a polymer, a colloidal particle, a nanoparticle, a nitrogen-rich molecule, or any combinations thereof. The method further includes exposing the cationic layer to an anionic solution to produce an anionic layer deposited on the cationic layer to produce a layer comprising the anionic layer and the cationic layer. The anionic solution comprises a layerable material.

Abstract: A method includes coating a substrate to provide a flame resistant substrate. In an embodiment, the method includes exposing the substrate to a cationic solution to produce a cationic layer deposited on the substrate. The cationic solution includes cationic materials. The cationic materials include polymers, nanoparticles, or any combinations thereof. The method further includes exposing the cationic layer to an anionic solution to produce an anionic layer deposited on the cationic layer to produce a bilayer. The bilayer is the anionic layer and the cationic layer. The anionic solution includes layerable materials.

Abstract: Provided herein provided is an assay system for monitoring drug susceptibility of a pathogenic bacteria comprising color-producing substrates for a beta-lactamase of the pathogenic bacteria, an assay device for visibly detecting a product of the beta-lactamase on the substrate thereof and a reader configured to quantify the visibly detected product. Also provided is an in vitro method to determine susceptibility to a drug effective against a pathogenic bacteria, for example, a pathogenic Mycobacteria, that has a beta-lactamase activity. An excitation wavelength is delivered to a biological sample obtained from a subject having an infection from the pathogenic bacteria in the presence of a beta-lactamase substrate. The intensity of a signal, such as a fluorescent, luminescent or colorimetric signal, at an emission wavelength of a product of the beta-lactamase on the subject is correlated to drug susceptibility.

Abstract: Provided herein are methods of metabolic kinetic phenotyping based on amino acids, proteins and other metabolites thereof. In the method a solution comprising a plurality of stable isotopes of amino acids is administered to the individual and one or more kinetic parameters of amino acids and the metabolites are calculated in blood samples taken periodically from the individual. The metabolic phenotype is composed from the kinetic parameters. Also provided are methods and kits for identifying a disease, such as chronic heart failure, in a patient using the metabolic parameters.

Abstract: Antibacterial metallic nanofoams, substrates having the nanofoam coated thereon, methods for preventing, inhibiting, and/or killing bacterial growth using the metallic nanofoams, and compositions and methods for making the metallic nanofoams.

Abstract: The present invention encompasses an osteogenic composition comprising mesenchymal stem cells pre-cultured in the presence of an agent that accelerates canonical Wnt signaling therein. Also, provided are osteogenic compositions incorporated into a biocompatible gel. The present invention provides methods for treating bone degeneration or injury associated with a pathophysiological condition in a mammal or for accelerating repair of a skeletal injury in a mammal by administering to the mammal or contacting the site of injury with the osteogenic composition.

Abstract: An intermedullary device and methods of use are described. The device is configured for fixation of a long bone and to facilitate healing of the long bone. The device comprises an elongate member having a first end, a second end, and a mid region. The mid region comprises a band or collar extending outwardly away from the outer surface of the device to increase all or a portion of the cross-sectional diameter of the mid region. The elongate member has a length that may be about the same as or less than the length of the long bone's diaphyseal region. The band further comprises at least one engaging surface configured for engaging with a cortical region of the long bone at a defect site. Use of the device facilitates healing of the long bone at or near the defect site. The method comprises providing a first end of the device in a first exposed region of the long bone's medullary canal. The method further comprises providing a second end of the device in a second exposed region of the medullary canal.

Abstract: Methods and composition for the production of non-flowering or late flowering sorghum hybrid. For example, in certain aspects methods for use of molecular markers that constitute the Ma5/Ma6 pathway to modulate photoperiod sensitivity are described. The invention allows the production of plants having improved productivity and biomass generation.

Abstract: The present invention encompasses methods, compositions, and devices for treating an ocular disease, disorder or condition in a mammal. The invention includes polypeptides that possess anti-inflammatory, anti-apoptotic, immune modulatory and anti-tumorigenic properties, and their application in the treatment of eye disease, particularly diseases of the retina. In particular aspects, the invention includes administration of a therapeutic polypeptide such as a stanniocalcin family member protein for the treatment of an eye disease. Also included are fusion proteins and cells stimulated or modified to express the therapeutic polypeptides as set forth herein.

Abstract: Methods and products for altering or promoting the development of heart tissue are disclosed. The methods include the use of nucleic acids of cardiogenic inducing factor for treating a subject having heart disease.

Abstract: A method and device produce thermoelectric power and thermoelectric modules. In one embodiment, a thermoelectric module comprises N-type carbon nanotube film and P-type carbon nanotube film.

Abstract: A system and computerized method for monitoring and analyzing animal related data. In one embodiment, the system includes a processor and memory operable to identify a parameter related to animal management for species in a biological environment, aggregate animal related data from different sources about the parameter of the species, identify a baseline for the parameter, correlate the animal related data against the baseline to obtain correlated data, and analyze said correlated data to assess said animal management.

Abstract: Systems and methods for forming nanoparticles in-situ are disclosed herein. The nanoparticles may be formed in-situ through thermocycling a solution comprising at least one of a molten salt, a surfactant, and a catalyst. The nanoparticles may form in the solution itself and/or on surfaces of a vessel in which the solution is formed. Nanofins may be formed from the agglomeration of particles in the solution and on surfaces. Microchannels may be formed by these nanofins, and in some cases microchannels on a surface may have nanofins form on the surface. In some embodiments, a previously formed solution that has nanoparticles formed in-situ may be used to generate nanofins in a vessel, on a wafer in a vessel, in the solution itself, or combinations thereof.

Abstract: The present disclosure provides compositions and methods for inhibiting ?1-integrin expression and functionality, and for addressing any condition characterized by increased ?1-integrin levels, through inhibition of NR4A1 (TR3) in the cell.

Abstract: Methods and composition for a melatonin signaling modulator-based diagnosis and therapy are described. For example, in certain aspects methods for administering an anti-tumor therapy using a melatonin signaling modulator are described. Furthermore, the invention provides compositions and methods for detecting biliary tract disease such as cholangiocarcinoma.

Abstract: ‘DALSA 0605’ is a new variety of St. Augustinegrass distinguished by having high tolerance to grey leaf spot disease, significantly reduced levels of fecundity and juvenile development of Southern chinch bugs, and superior drought resistance conferred through a combination of tolerance to drying soil, deep genetic rooting potential, and rapid recovery following drought, as disclosed herein.