Abstract: A therapeutic method for catalytically forming persulfide and/or polysulfide from hydrogen sulfide in vitro and in vivo using endogenously or exogenously released hydrogen sulfide is disclosed. That method comprises contacting cells in need including those under oxidative stress, traumatic brain injury (TBI) and hypoxia, or have an excess of hydrogen sulfide or deficiency of protein persulfidation with oxidized carbon nanoparticulate material in which the particles contain a plurality of carbonyl, hydroxyl and carboxyl substituents. Oxidized carbon nanoparticulate (OCN) material can be prepared from any of a variety of sources of which activated charcoal is preferred. A water-dispersible OCN material is described that does not need added hydrophilic polymers to provide dispersibility for at least 7 days at a concentration of about 1-5 mg/mL. These OCN materials also have a UV absorbance maximum in water of about 220 nm and pass through a 0.22 µm pore PES membrane.

Abstract: A process for continuously upgrading heavy oil to produce light hydrocarbon gases which are recycled in the process as a carrier gas used in spark-discharge hydrocarbon cracking within the process. The process also produces light hydrocarbon liquids which are used to upgrade the heavy oil. An apparatus for continuously upgrading heavy oil to produce light hydrocarbon gases which are recycled in the as a carrier gas used in spark-discharge hydrocarbon cracking within the apparatus. The apparatus also produces light hydrocarbon liquids which are used to upgrade the heavy oil.

Abstract: A cartilage mimetic gel includes double network hydrogels. The double network hydrogels comprise a first crosslinked network and a second crosslinked network. The first crosslinked network can be formed from poly(2-acrylamido-2-methylpropane sulfonic acid). The second crosslinked network can be formed from poly(N-isopropyl acrylamide-co-acrylamide).

Abstract: A device includes an input converter, an output converter, and a controller. The input converter is electrically coupled to an electrical meter and an energy production array. The output converter is electrically coupled to the energy production array and a load. The controller is communicatively coupled to the input converter, the output converter, the energy production array, and the load. The input converter and the output converter are positioned between the electrical meter and the load.

Abstract: The present disclosure relates to methods of treating Coronavirus-Associated Lung Damage (CALD) and cytokine storm using CALD-treating compounds. The methods can involve administering CALD-treating compounds to a patient suffering from CALD or cytokine storm.

Abstract: A fluazifop-resistant sorghum cultivar designated ‘21534_ACCase-R’ and plants comprising a polynucleotide encoding the polypeptide of SEQ ID NO: 39 are disclosed herein. The present invention provides seeds, plants, and plant parts derived from sorghum cultivar ‘21534_ACCase-R’ and those including SEQ ID NO: 39. Further, it provides methods for producing a sorghum plant by crossing ‘21534_ACCase-R’ with itself or another sorghum variety. The invention also encompasses any sorghum seeds, plants, and plant parts produced by the methods disclosed herein, including those in which additional traits have been transferred into ‘21534_ACCase-R’ through the introduction of a transgene or by breeding ‘21534_ACCase-R’ with another sorghum cultivar.

Abstract: The disclosure provides a method for cleaning an implanted medical device. In one embodiment, the method includes providing a medical device including a membrane; wherein the membrane comprises a thermoresponsive hydrogel including N-isopropylacrylamide (NIPAAm) or poly(N-isopropylacrylamide) (PNIPAAm), and a volume phase transition temperature (VPTT). The method also includes implanting the medical device into a target area; wherein the membrane temperature is maintained at substantially the same temperature as the target area; wherein temperature fluctuations within the target area that approach, meet and/or exceed the volume phase transition temperature induce deswelling or relative deswelling in the membrane and temperature fluctuations within the target area that are relatively lower and/or approach and/or fall below the volume phase transition temperature induce swelling or relative swelling in the membrane.

Abstract: The present disclosure relates to methods of treating Coronavirus-Associated Lung Damage (CALD) and cytokine storm using CALD-treating polypeptides. The methods can involve administering serum amyloid P-component to a patient suffering from CALD or cytokine storm.

Abstract: Endolysosomal targeting conjugates that are engineered to deliver cargo molecules such as cytotoxic drugs or imaging labels with improved efficiency to late endosomes and/or lysosomes in target cells such as tumor cells are described. The endolysosomal targeting conjugate includes a targeting component and a cargo component. The targeting component is configured to bind to a cell surface molecule of a target cell and the cargo component includes a cargo molecule. The targeting component and the cargo component may be fused by a covalent bond or associated by a non-covalent bond. The targeting component may bind to the cell surface molecule or the cargo component with higher affinity in the extracellular space than in an endolysosomal compartment of the target cell.

Abstract: Disclosed herein are antisense oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA at the 5?-end of UBE3A-AS, which is downstream of SNORD115-45 snoRNA. Also disclosed are pharmaceutical compositions and methods for treatment of Angelman syndrome.

Abstract: Processes of polymerizing polyolefins and synthesis of activators. The polymerization processes include polymerizing one or more (C2-C12)?-olefin monomers in the presence of at least one catalyst and at least one co-catalyst to produce a polyolefin. The co-catalyst includes a cation and an anion, in which the anion has a structure having a vinyl terminated alkene, one boron atom or more than one boron atoms, and at least four halogen atoms. The anion of the co-catalysts is incorporated into a polymer chain of the polyolefin.

Abstract: The system includes a gas tank. A reference volume is fluidly coupled to the gas tank. A coreholder fluidly is coupled to the reference volume. A sample is disposed in the coreholder. A fluid pump is fluidly coupled to the coreholder. A first pressure transducer is fluidly coupled between the fluid pump and the coreholder. The first pressure transducer measures a confining pressure. A second pressure transducer is fluidly coupled to the coreholder. The second pressure transducer measures upstream pressure within the coreholder.

Abstract: A multi-modal vehicle includes a frame, a rotor pivotally mounted to the frame, the rotor including a first position and a second position circumferentially spaced from the first position, and a motor coupled to the rotor and configured to rotate the rotor, wherein, when the rotor is disposed in the first position, the rotor is configured to generate lift when actuated by the motor, wherein, when the rotor is disposed in the second position, the rotor is configured to engage a surface to transport the vehicle when actuated by the motor.

Abstract: A composition includes a thermoplastic polymer and a polyrotaxane. The polyrotaxane includes a plurality of cyclic molecules and a chain polymer passing through the plurality of the cyclic molecules in a skewering manner, at least a part of the hydroxyl groups of the plurality of cyclic molecules being substituted with a hydrophobic group. A group that enhances miscibility of the polyrotaxane to the thermoplastic polymeris bound to at least a part of the hydrophobic groups of each of the plurality of cyclic molecules.

Abstract: Methods and systems of 3D printing non-photocurable thermosetting polymer materials and continuous fiber composites that reduces the manufacturing time and energy required by implementing fast, self-sustaining, and self-propagating, in-situ curing of the polymer and the and continuous fiber composites as the non-photocurable thermosetting polymer materials are being printed.

Abstract: A method for inspecting a photomask includes scanning the photomask with an interferometric fringe pattern generated by an interferometer, generating an interferogram associated with the photomask in response to scanning the photomask using the interferometer, and detecting one or more geometric parameters of the photomask using the generated interferogram.

Abstract: A resin composition is provided. The resin composition includes a rigid polymer resin, a functionalized polyrotaxane, and (optionally) a core-shell polymer. The resin composition may be cured to form a cured thermoset resin. The cured thermoset set has improved mechanical properties relative to a reference cured thermoset. A method of preparing a cured article of the curable resin composition is also provided. The method includes providing the curable resin composition and curing the curable composition.

Abstract: An apparatus for surgical lighting is disclosed. The apparatus includes a light emitting element formed with a light source encapsulated within an outer layer. The outer layer includes a biocompatible material. A power supply is coupled to the light source. The apparatus includes an actuating mechanism that controls power from the power supply to the light source to emit light along a surgical area. The light emitting element provides enhanced illumination and other surgical advantages.

Abstract: A variety of fluid loss control compositions and methods are provided for controlling fluid loss in a cementing operation. As described herein, polyelectrolyte complex nanoparticles and fluid loss control compositions containing polyelectrolyte complex nanoparticles can be effective for fluid loss control in a variety of cementing operations. Methods of making and methods of using the electrolyte complex nanoparticles and fluid loss control compositions containing polyelectrolyte complex nanoparticles are also provided. The polyelectrolyte complex nanoparticles can include a polycation polymer such as a branched chain polyethylenimine, and a polyanion polymer such as polyacrylic acid or poly(vinylsulfonic) acid. The polyelectrolyte complex nanoparticles can contain additional additives such as metal ions or fluid loss additives such as a cellulose polymer.

Abstract: Bio-Inks and methods of using compositions comprising the bio-Inks are disclosed. 3-D tissue repair and regeneration through precise and specific formation of biodegradable tissue scaffolds in a tissue site using the bio-inks are also provided. Specific methylacrylated gelatin hydrogels (MAC) and methacrylated chitosan (MACh) preparations formulated with sucrose, a silicate-containing component (such as laponite), and/or a cross-linking agent (such as a photo-initiator or chemical initiator), as well as powdered preparations of these, are also disclosed. Kits containing these preparations are provided for point-of-care tissue repair in vivo. Superior, more complete (up to 99.85% tissue regeneration within 4 weeks applied in situ), and rapid in situ tissue repair and bone formation are also demonstrated.