Abstract: Vaccine compositions including a yeast comprising an immunostimulatory polypeptide and optionally an antigenic polypeptide are provided herein. The immunostimulatory polypeptide and the antigenic polypeptide are expressed or displayed on the surface of the yeast vaccine composition. Methods of using the vaccine composition to vaccinate subjects are also provided.
Type:
Application
Filed:
June 11, 2020
Publication date:
September 24, 2020
Applicants:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, The Texas A&M University System
Inventors:
Olivia B. Faulkner, Lisa Bielke, Leona Nicole Calhoun, Luc Berghman, Billy Hargis
Abstract: An embodiment includes a system comprising: a monolithic shape memory polymer (SMP) foam having first and second states; wherein the SMP foam includes: (a) polyurethane, (b) an inner half portion having inner reticulated cells defined by inner struts, (c) an outer half portion, having outer reticulated cells defined by outer struts, surrounding the inner portion in a plane that provides a cross-section of the SMP foam, (d) hydroxyl groups chemically bound to outer surfaces of both the inner and outer struts. Other embodiments are discussed herein.
Type:
Grant
Filed:
July 22, 2016
Date of Patent:
September 22, 2020
Assignees:
Lawrence Livermore National Security, LLC, The Texas A&M University System
Inventors:
Landon D. Nash, Duncan J. Maitland, Nicole Docherty, Thomas S. Wilson, Ward Small, IV, Jason Ortega, Pooja Singhal
Abstract: Disclosed are non-noble element compositions of matter, structures, and methods for producing the catalysts that can catalyze oxygen reduction reactions (ORR). The disclosed composition of matter can be comprised of graphitic carbon doped with nitrogen and associated with one or two kinds of transition metals. The disclosed structure is a three dimensional, porous structure comprised of a plurality of the disclosed compositions of matter. The disclosed structure can be fashioned into an electrode of an electrochemical cell to serve as a diffusion layer and also to catalyze an ORR. Two methods are disclosed for producing the disclosed composition of matter and structure. The first method is comprised of two steps, and the second method is comprised of a single step.
Abstract: The present invention provides a biodegradable “precision polymer system” (poly system) and methods for preparing pharmaceutically effective “precision polymer nanosystems” (polymer nanosystem) for delivery and/or targeting of drugs or drug like compounds.
Abstract: A method of applying a gas-impermeable coating includes forming a polyelectrolyte complex suspension. The polyelectrolyte complex suspension is applied to a substrate. The substrate having the polyelectrolyte complex applied theron is treated. The treating reduces salt content of the polyelectrolyte complex.
Type:
Application
Filed:
October 18, 2017
Publication date:
September 17, 2020
Applicant:
The Texas A&M University System
Inventors:
Jaime C. Grunlan, Merid Haile, Ryan Smith
Abstract: An energy storage device and method of forming and operating the same. In one embodiment, the energy storage device includes a positive electrode including a first redox polymer deposited on a first conductive porous substrate. The energy storage device also includes a solid-state polyelectrolyte separator operative as a voltage generator, and a negative electrode including a second redox polymer deposited on a second conductive porous substrate, thereby forming an electrochemical cell.
Abstract: The present invention provides a method for treating inflammatory conditions, for example, inflammatory bowel disease, ulcerative colitis induced inflammatory bowel disease, spinal cord injury or spaceflight-induced immune dysregulation and associated comorbidities in a mammal or subject in need of such treatment. The present invention also provides a method for decreasing osteocyte protein levels in a mammal suffering from inflammatory condition. A pharmacologically effective does of Irisin or a pharmaceutical composition of irisin is administered to the mammal or subject one or more times.
Type:
Application
Filed:
October 25, 2018
Publication date:
September 17, 2020
Applicant:
Texas A&M University System
Inventors:
Corinne Metzger, Anand Narayanan, David Zawieja, Susan Bloomfield
Abstract: Embodiments of the claimed invention are directed to a device, comprising: an anode that includes a lithiated silicon-based material and a sulfur-based cathode, wherein the anode and the cathode are designed to have mesoporous structures. In certain embodiments, the sulfur-based cathode is a mesoporous carbon structure comprising sulfur within the mesopores. A further embodiment of the invention is directed to a device comprising a semi-liquid lithium-sulfur battery comprising a lithium anode and a sulfur cathode. In certain embodiments, the sulfur cathode comprises a liquid catholyte, which is housed within a reservoir that is a carbon nanotube sponge. An additional embodiment of the invention is directed to a method for producing a lithiated silicon anode and a sulfur-based cathode.
Abstract: The invention relates to methods for treating cancers by targeting the elimination of selective activated immune cell populations in combination with checkpoint inhibitors. The cells may be targeted, for instance, using CLIP inhibitors and or MHC class II inducers.
Type:
Application
Filed:
September 14, 2018
Publication date:
August 27, 2020
Applicants:
The Texas A&M University System, The Regents of the University of Colorado, a Body Corporate
Inventors:
Richard Tobin, Martha Karen Newell-Rogers
Abstract: A device includes an input converter, an output converter, and a controller. The input converter is electrically coupled to an electrical meter and an energy production array. The output converter is electrically coupled to the energy production array and a load. The controller is communicatively coupled to the input converter, the output converter, the energy production array, and the load. The input converter and the output converter are positioned between the electrical meter and the load.
Type:
Application
Filed:
September 28, 2018
Publication date:
August 27, 2020
Applicant:
The Texas A&M University System
Inventors:
PANGANAMALA R. KUMAR, LE XIE, PRASAD N. ENJETI
Abstract: Methods and compositions for the production of monocot plants with increased starch content in stems are provided. In accordance with the invention, novel promoters and regulatory elements with specific temporal and spatial expression patterns are disclosed together with methods for the production of plants having desirable stem composition at harvest.
Abstract: A venous valve model includes a first layer having a central axis and a fluid channel extending between a fluid inlet and a fluid outlet formed in the first layer, wherein the fluid channel is defined by a pair of channel walls, a first venous valve formed in the first layer and positioned along the fluid channel, and a pair of first actuation chambers positioned adjacent the channel walls of the fluid channel, wherein the pair of first actuation chambers are configured to decrease a width of the fluid channel in response to pressurization of the pair of first actuation chambers.
Abstract: Phase change material compositions and methods for using the compositions to prepare substrate coatings or bulk blended polymers that advantageously lower friction between interacting substrate surfaces and lower substrate surface wear.
Abstract: An embodiment includes a platform shape memory polymer system. Such an embodiment exhibits a blend of tunable, high performance mechanical attributes in combination with advanced processing capabilities and good biocompatibility. A post-polymerization crosslinking synthetic approach is employed that combines polyurethane and thiol-ene synthetic processes. Other embodiments are described herein.
Type:
Grant
Filed:
February 2, 2016
Date of Patent:
August 4, 2020
Assignees:
Lawrence Livermore National Security, LLC, The Texas A&M University System
Inventors:
Keith Hearon, Landon D. Nash, Thomas Wilson, Duncan J. Maitland, Mark A. Wierzbicki
Abstract: An apparatus configured to detect a substance, and method of operating and forming the same. In one embodiment, the apparatus includes a tunable resonator including an upper Bragg reflector and a lower Bragg reflector separated by a porous matrix. The tunable resonator is configured to be illuminated by a light source and produce a first spectral optical response from a substance absorbed within the porous matrix. The apparatus also includes a detector positioned proximate the tunable resonator configured to provide a first absorption signal representing the first spectral optical response.
Abstract: Inefficient dissipation of heat limits the performance of electronic devices. Thermal interface materials (TIMs) can be used in electronic devices to dissipate heat more effectively and efficiently. Nanocomposites have been prepared using functionalized boron nitride nanosheets (BNNS). The incorporation of soft-ligand functionalized BNNS in a metal matrix was used to nanofabricate kinetically-trapped nanocomposites TIMs.
Type:
Grant
Filed:
March 17, 2016
Date of Patent:
August 4, 2020
Assignee:
THE TEXAS A&M UNIVERSITY SYSTEM
Inventors:
Mustafa Akbulut, Cengiz Yegin, Nirup K. Nagabandi, Blake Teipel
Abstract: Methods and systems include determining travel information from vehicles. In one embodiment, a system monitors traffic on a roadway in real-time. The system includes a plurality of reader devices. The reader devices are capable of asynchronously capturing a unique network identifier of a device in a vehicle when the device is disposed in reader range of the reader devices. The reader device time stamps each captured unique network identifier. The time stamped unique network identifier is forwarded to a host module. The host module receives the time stamped unique network identifier. In addition, the host module determines travel information from the time stamped unique network identifier by comparing the time stamped unique network identifier for a particular vehicle to other time stamped unique network identifiers captured for the particular vehicle.
Abstract: A waveguide structure including a mid-infrared-transparent waveguide on a mid-infrared-transparent undercladding may serve as a photonic chemical sensor for measuring characteristic absorptions of analytes brought in physical contact with the waveguide. In some embodiments, a sensor including an amorphous-silicon waveguide on a barium-titanate undercladding can operate at wavelengths ranging from 2.5 ?m to about 7 ?m; this sensor may be manufactured by epitaxial growth of the undercladding on a substrate, followed by CMOS-compatible creation of the waveguide. Additional embodiments are disclosed.
Abstract: Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD154 polypeptide or an HMGB1 polypeptide.
Type:
Grant
Filed:
August 5, 2019
Date of Patent:
July 21, 2020
Assignees:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM
Inventors:
Lisa Bielke, Sherryll Layton, Billy Hargis, Neil R. Pumford, Olivia B. Faulkner, Luc Berghman, Daad Abi-Ghanem
Abstract: ‘15173 GR’ is a new and distinct hardy herbaceous Hibiscus hybrid with novel characteristics that include upright branched stems, numerous, outward-facing, flowers that exhibit a background that is between moderate yellowish pink and strong pink in the mid and upper part, and between vivid reddish orange and deep yellowish pink from the middle part down to the edge of the center eye, a strong red center eye, a prolonged blooming season, and hastate, trilobed leaves.
Type:
Grant
Filed:
May 22, 2019
Date of Patent:
July 21, 2020
Assignee:
The Texas A&M University System
Inventors:
Dariusz P. Malinowski, William E. Pinchak, R. Steve Brown