Patents Assigned to Texas Heart Institute
  • Patent number: 11981895
    Abstract: Embodiments of the disclosure include methods and compositions for the renewal of cardiomyocytes by targeting the Hippo pathway. In particular embodiments, an individual with a need for cardiomyocyte renewal is provided an effective amount of a shRNA molecule that targets the Sav1 gene. Particular shRNA sequences are disclosed.
    Type: Grant
    Filed: September 12, 2022
    Date of Patent: May 14, 2024
    Assignee: Baylor College of Medicine and Texas Heart Institute
    Inventors: James F. Martin, Yuka Morikawa, Todd Ryan Heallen, John Leach
  • Patent number: 11969591
    Abstract: An Example tool for implanting a pacemaker lead includes a body that includes a recess, a first electrical contact positioned within the recess, and a projection coupled to the body. In addition, the tool includes a second electrical contact positioned on the projection. The recess is configured to receive the pacemaker lead therein such that a first electrode of the pacemaker lead is to engage with the first electrical contact and a second electrode of the pacemaker lead is to engage with the second electrical contact. A rotation of the tool about a central axis of the pacemaker lead is configured to rotate the first electrical contact and the first electrode together about the central axis and to slidingly engage the second electrical contact along the second electrode.
    Type: Grant
    Filed: October 28, 2021
    Date of Patent: April 30, 2024
    Assignee: Texas Heart Institute
    Inventors: Maryam Nuru, Ronit Kar, Mathews Medayil John, Allison Davis Post, Skylar Jobe Buchan, Mehdi Razavi
  • Patent number: 11911625
    Abstract: Systems and methods for heart stimulation in accordance with embodiments of the invention are illustrated.
    Type: Grant
    Filed: November 20, 2019
    Date of Patent: February 27, 2024
    Assignees: The Regents of the University of California, Texas Heart Institute
    Inventors: Aydin Babakhani, Hongming Lyu, Razavi Mehdi, Mathews M. John, Allison Post
  • Patent number: 11751759
    Abstract: One aspect of the invention provides a trocar including: a central cylinder defining a central channel and having a distal end adapted and configured for insertion within a subject; one or more gas outlets located within the central cylinder proximate to the distal end of the trocar; and one or more liquid outlets located within the central cylinder on a proximal side of the one or more gas outlets. The one or more liquid outlets are adapted and configured to dispense a liquid when an endoscope is withdrawn from a fully extended position within the central channel of the trocar to a position proximate to the one or more liquid outlets. Distal advancement of the endoscope to a position adjacent to the one or more gas outlets removes liquid from a distal end of the endoscope.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: September 12, 2023
    Assignees: Baylor College of Medicine, Texas Heart Institute
    Inventors: Bryan M. Burt, Mahmood Khan, William Cohn
  • Patent number: 11712559
    Abstract: Wireless treatment of arrhythmias. At least some of the example embodiments are methods including: charging a capacitor of a first microchip device abutting heart tissue, the charging by harvesting ambient energy; charging a capacitor of a second microchip device abutting the heart tissue, the charging of the capacitor of the second microchip device by harvesting ambient energy; sending a command wirelessly from a communication device outside the rib cage to the microchip devices; applying electrical energy to the heart tissue by the first microchip device responsive to the command, the electrical energy applied from the capacitor of the first microchip device; and applying electrical energy to the heart tissue by the second microchip device responsive to the command to the second microchip device, the electrical energy applied from the capacitor of the second microchip device.
    Type: Grant
    Filed: May 14, 2021
    Date of Patent: August 1, 2023
    Assignees: William Marsh Rice University, Texas Heart Institute, Baylor College of Medicine
    Inventors: Yuxiang Sun, Aydin Babakhani, Mehdi Razavi, David Burkland, Brian Greet, Mathews John, Hongming Lyu
  • Publication number: 20230181211
    Abstract: A surgical cutting device for performing a minimally-invasive surgical procedure and which includes an external hub including a housing and a cutter actuator housed within the housing, wherein the cutter actuator, a catheter including a first end coupled to the external hub, a second end opposite the first end, and an internal passage, a cutting tool coupled to the second end of the catheter and including a cutting element moveable relative to the second end of the catheter by the cutter actuator, and a motion transfer assembly extending through the internal passage of the catheter from the cutter actuator to the cutting tool, wherein the motion transfer assembly is configured to transfer motion from the cutter actuator to the cutting element of the cutting tool in response to the activation of the cutter actuator.
    Type: Application
    Filed: December 8, 2022
    Publication date: June 15, 2023
    Applicant: TEXAS HEART INSTITUTE
    Inventors: Skylar J. Buchan, Mathews M. John, Allison Davis Post, Mehdi Razavi, Drew Bernard, Jayachandrika Jayavasudevan
  • Publication number: 20220339436
    Abstract: A method of improving electrical conduction across an impaired region of a tissue (e.g., myocardial tissue), includes applying an electrically conductive wiring carbon nanotube fibers) across the impaired region. The electrically conductive wiring can become associated with non-impaired regions of the tissue on opposite sides of the impaired region by suturing. The method can also be utilized to treat or prevent cardiac arrhythmia in a subject (e.g., ventricular arrhythmia). The electrically conductive wiring includes carbon nanotubes, such as carbon nanotube fibers, Such electrically conductive wiring can be used to transmit electrical signals to a tissue or sense electrical signals from the tissue. Suture threads including carbon nanotubes, such as carbon nanotube fibers, are provided.
    Type: Application
    Filed: July 11, 2022
    Publication date: October 27, 2022
    Applicants: William Marsh Rice University, Baylor College of Medicine, Texas Heart Institute
    Inventors: Matteo Pasquali, Mehdi Razavi, Flavia Vitale, Colin Christopher Young, Mark David McCauley
  • Publication number: 20220192480
    Abstract: One aspect of the invention provides a trocar including: a central cylinder defining a central channel and having a distal end adapted and configured for insertion within a subject; one or more gas outlets located within the central cylinder proximate to the distal end of the trocar; and one or more liquid outlets located within the central cylinder on a proximal side of the one or more gas outlets. The one or more liquid outlets are adapted and configured to dispense a liquid when an endoscope is withdrawn from a fully extended position within the central channel of the trocar to a position proximate to the one or more liquid outlets. Distal advancement of the endoscope to a position adjacent to the one or more gas outlets removes liquid from a distal end of the endoscope.
    Type: Application
    Filed: March 11, 2022
    Publication date: June 23, 2022
    Applicants: Baylor College of Medicine, Texas Heart Institute
    Inventors: Bryan M. BURT, Mahmood KHAN, William COHN
  • Patent number: 11312685
    Abstract: Disclosed herein is a composition comprising a plurality of liposomes having an average diameter of less than 400 nanometers, wherein the plurality of liposomes comprise: a first lipid or phospholipid; a second lipid or phospholipid which is derivatized with a polymer; and a sterically bulky excipient capable of stabilizing the liposomes; a third lipid or phospholipid derivatized with a polymer terminated with an integrin targeting component; DSPE or a fourth lipid or phospholipid derivatized with a group binding a contrast enhancing agent wherein the plurality of liposomes optionally encapsulates a payload component consisting of one or more bioactive agents.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: April 26, 2022
    Assignees: Texas Heart Institute, Texas Children's Hospital
    Inventors: Darren Woodside, Peter Vanderslice, Robert Market, Ronald Biediger, Richard Dixon, James T. Willerson, Ananth Annapragada, Eric Tanifum
  • Patent number: 11311619
    Abstract: Vaccine compositions including one or more antigens and one or more integrin agonists or activating compounds present in an amount sufficient to increase an immune response of a patient to the one or more antigens.
    Type: Grant
    Filed: July 3, 2020
    Date of Patent: April 26, 2022
    Assignee: 7 Hills Pharma Inc. and Texas Heart Institute
    Inventors: Darren G. Woodside, Peter Vanderslice, Upendra K. Marathi
  • Publication number: 20220008736
    Abstract: Systems and methods for heart stimulation in accordance with embodiments of the invention are illustrated.
    Type: Application
    Filed: November 20, 2019
    Publication date: January 13, 2022
    Applicants: The Regents of the University of California, Texas Heart Institute
    Inventors: Aydin Babakhani, Hongming Lyu, Razavi Mehdi, Mathews M. John, Allison Post
  • Publication number: 20220001009
    Abstract: Pharmaceutical compositions including one or more integrin activating compounds capable of enhancing an anti-tumor activity of one or more therapeutic antibodies, one or more immune checkpoint inhibitors, or mixtures thereof.
    Type: Application
    Filed: June 29, 2021
    Publication date: January 6, 2022
    Applicants: 7 Hills Pharma LLC, Texas Heart Institute
    Inventors: Darren G. Woodside, Peter Vanderslice, Upendra K. Marathi
  • Patent number: 11173296
    Abstract: A medical devices and methods related thereto are disclosed. In an embodiment, the medical device including a pump configured to be inserted within an atrium of a heart, said pump comprising an inlet and an outlet. In addition, the pump includes a flexible outflow conduit coupled to the outlet and configured to carry blood. The outflow conduit includes a radially inner surface defining a throughbore, and a radially outer surface. Further, the pump comprises a driveline configured to conduct control and power signals between the pump and an external device. The driveline extends through the outflow conduit between the radially inner surface and the radially outer surface.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: November 16, 2021
    Assignee: Texas Heart Institute
    Inventors: Oscar H. Frazier, William E. Cohn
  • Publication number: 20210339017
    Abstract: Wireless treatment of arrhythmias. At least some of the example embodiments are methods including: charging a capacitor of a first microchip device abutting heart tissue, the charging by harvesting ambient energy; charging a capacitor of a second microchip device abutting the heart tissue, the charging of the capacitor of the second microchip device by harvesting ambient energy; sending a command wirelessly from a communication device outside the rib cage to the microchip devices; applying electrical energy to the heart tissue by the first microchip device responsive to the command, the electrical energy applied from the capacitor of the first microchip device; and applying electrical energy to the heart tissue by the second microchip device responsive to the command to the second microchip device, the electrical energy applied from the capacitor of the second microchip device.
    Type: Application
    Filed: May 14, 2021
    Publication date: November 4, 2021
    Applicants: WILLIAM MARSH RICE UNIVERSITY, TEXAS HEART INSTITUTE, BAYLOR COLLEGE OF MEDICINE
    Inventors: Yuxiang SUN, Aydin BABAKHANI, Mehdi RAZAVI, David BURKLAND, Brian GREET, Mathews JOHN, Hongming LYU
  • Patent number: 11071857
    Abstract: Wireless treatment of arrhythmias. At least some of the example embodiments are methods including: charging a capacitor of a first microchip device abutting heart tissue, the charging by harvesting ambient energy; charging a capacitor of a second microchip device abutting the heart tissue, the charging of the capacitor of the second microchip device by harvesting ambient energy; sending a command wirelessly from a communication device outside the rib cage to the microchip devices; applying electrical energy to the heart tissue by the first microchip device responsive to the command, the electrical energy applied from the capacitor of the first microchip device; and applying electrical energy to the heart tissue by the second microchip device responsive to the command to the second microchip device, the electrical energy applied from the capacitor of the second microchip device.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: July 27, 2021
    Assignees: William Marsh Rice University, Baylor College of Medicine, Texas Heart Institute
    Inventors: Yuxiang Sun, Aydin Babakhani, Mehdi Razavi, David Burkland, Brian Greet, Mathews John, Hongming Lyu
  • Publication number: 20210023207
    Abstract: Vaccine compositions including one or more antigens and one or more integrin agonists or activating compounds present in an amount sufficient to increase an immune response of a patient to the one or more antigens.
    Type: Application
    Filed: July 3, 2020
    Publication date: January 28, 2021
    Applicants: 7 Hills Pharma LLC, Texas Heart Institute
    Inventors: Darren G. Woodside, Peter Vanderslice, Upendra K. Marathi
  • Patent number: 10799333
    Abstract: A magnet assisted surgical device, system, and method employs magnetic sections, catheters, and guidewires to modify tubular stentgrafts in-situ. One example application provides a more reliable way for surgeons to modify stentgrafts insitu to allow blood flow to continue to branching blood vessels that would otherwise be blocked by the stentgraft itself. One such method includes placing a tip section of the device in the desired location, deploying a stentgraft, placing a magnetic device inside the stentgraft, connecting the magnetic device to the tip section, and excising the portion of the stentgraft held between the magnet and the tip section.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: October 13, 2020
    Assignees: Baylor College of Medicine, Texas Heart Institute
    Inventors: Ramyar Gilani, Ourania Preventza, William E. Cohn
  • Patent number: 10751119
    Abstract: Herein disclosed is a method of detecting and identifying the source of abnormal electrical currents in the heart to assist in ablating these currents, comprising the use of contact or non-contact temperature measurement devices. In an embodiment, source of abnormal electrical activity of the heart and its attached arteries and veins show different temperature patterns from normal segments. In an embodiment, the method further comprises analyzing the temperature of the chamber of interest, and determining regions of low or high temperature by extension metabolic activity. In an embodiment, the method comprises measuring myocardial temperature comprising placing an array of thermocouples imbedded on a basket in the cardiac chamber. In an embodiment, the thermocouples are placed in contact with the myocardial tissue.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: August 25, 2020
    Assignee: TEXAS HEART INSTITUTE
    Inventors: Mehdi Razavi, Mohammad Madjid, James T. Willerson
  • Publication number: 20200054743
    Abstract: Methods for priming of vaccines including administering to a patient a composition including one or more integrin activating compounds capable of adjuvanting an antigen and capable of adjuvanting one or more antigens contained in a vaccine preparation.
    Type: Application
    Filed: July 19, 2019
    Publication date: February 20, 2020
    Applicants: 7 Hills Pharma LLC, Texas Heart Institute
    Inventors: Darren G. Woodside, Peter Vanderslice, Upendra K. Marathi
  • Publication number: 20190351052
    Abstract: Compositions including one or more antigens and one or more integrin activating compounds capable of adjuvanting the one or more antigens contained and increasing an immune response to the one or more antigen in a vaccine preparation.
    Type: Application
    Filed: April 25, 2019
    Publication date: November 21, 2019
    Applicants: 7 Hills Pharma LLC, Texas Heart Institute
    Inventors: Darren G. Woodside, Peter Vanderslice, Upendra K. Marathi