Abstract: Provided are methods, devices and compositions for reducing and/or inhibiting postsurgical tissue adhesion using a hydrogel film disposed onto a target tissue, thereby providing an adhesion barrier that remains over said target tissue for a prescribed period of time. In some embodiments, the hydrogel film is formed by the gelation of a pre-gel mixture applied onto the target tissue as a plurality of particles having an average maximum dimension, such as diameter, of at most about 500 ?m. In some embodiments, the hydrogel film has a minimum storage modulus of 100 Pa. In some embodiments, the pre-gel mixture comprises an ECM digest having a collagen to carbohydrate ratio (by mass) of at least 70:1.
Type:
Grant
Filed:
August 26, 2022
Date of Patent:
March 12, 2024
Assignee:
TEXAS MEDICAL CENTER
Inventors:
Timothy J. Keane, Jr., Peter Alexander Smith, Stephen G. Ramon
Abstract: Tactile sensing devices, systems, and methods to image a target tissue location are disclosed. When force is applied to the tactile sensing device, voltage data is detected and visualized on a screen, indicating the target tissue location.
Type:
Grant
Filed:
March 21, 2018
Date of Patent:
November 23, 2021
Assignee:
TEXAS MEDICAL CENTER
Inventors:
Nicole C. Moskowitz, Jessica Traver, Xavier Garcia-Rojas, Yashar Ganjeh
Abstract: Provided herein are catheter devices, systems, and methods to ablate a tissue location. The devises, systems, and methods disclosed herein comprise catheters comprising a fenestrated nozzle, ablation balloons, and an ablation medium that is directed at a tissue location.
Type:
Application
Filed:
August 7, 2020
Publication date:
November 19, 2020
Applicant:
Texas Medical Center
Inventors:
Benjamin Morgan LEGUM, Shadi SHARIATNIA, Matthew Aria NOJOOMI, Kovi Ethan BESSOFF
Abstract: Tactile sensing devices, systems, and methods to image a target tissue location are disclosed. When force is applied to the tactile sensing device, voltage data is detected and visualized on a screen, indicating the target tissue location.
Type:
Grant
Filed:
May 2, 2017
Date of Patent:
June 26, 2018
Assignee:
TEXAS MEDICAL CENTER
Inventors:
Nicole C. Moskowitz, Jessica Traver, Xavier Garcia-Rojas, Yashar Ganjeh
Abstract: Linear double-stranded DNA fragments containing a promoter, a nucleotide sequence, such as a transgene, preferably non-viral, and a 3′ untranslated region, are delivered to tissue of an animal by direct injection accompanied by electroporation. Long-term expression of the transgene results in prolonged availability of proteins, hormones, or enzymes that may be deficient in the mammal. In addition, the linear fragments increase the safety of the vectors for mammalian gene therapy by avoiding deleterious side effects.
Type:
Application
Filed:
September 6, 2002
Publication date:
August 21, 2003
Applicant:
Baylor College of Medicine Texas Medical Center
Abstract: The subject invention provides for the production of lactoferrins and lactoferrin polypeptide fragments using the host cells Aspergillus in combination with novel plasmid constructs. More specifically, the subject invention provides novel vector constructs capable of producing lactoferrins and lactoferrin polypeptide fragments in Aspergillus host cells. More particularly, the subject invention provides for novel plasmid constructs suitable for use with Aspergillus and especially Aspergillus awamori, niger and oryzae host cells, which enables them to produce large amounts of recombinant lactoferrins and lactoferrin polypeptide fragments.
Type:
Grant
Filed:
November 2, 1994
Date of Patent:
November 5, 1996
Assignee:
Baylor College of Medicine Texas Medical Center
Inventors:
Orla M. Conneely, Denis R. Headon, Bert W. O'Malley
Abstract: A refrigerant leak detection apparatus and method for testing for leaking frigerant within a heat exchanging fluid, particularly for testing for leaking refrigerant in a chiller system comprising heat exchangers.
Type:
Grant
Filed:
March 31, 1995
Date of Patent:
June 11, 1996
Assignee:
Texas Medical Center Central Heating and Cooling Cooperative Association
Abstract: A refrigerant leak detection apparatus and method for testing for leaking frigerant within a heat exchanging fluid, particularly for testing for leaking refrigerant in a chiller system comprising heat exchangers.
Type:
Grant
Filed:
December 3, 1993
Date of Patent:
October 4, 1994
Assignee:
Texas Medical Center Central Heating and Cooling Cooperative Association