Patents Assigned to Texas Tech Univeristy System
  • Patent number: 12013396
    Abstract: Disclosed is a system and method for a microdevice to separate blood cells based on differences in antigen expression. Specifically, cells of the same phenotype are separated based on whether or not they are activated during infection or resting. The device of the present disclosure takes a small sample of blood and provides differential cell counts that can be used to test for infection and inflammatory response. The device can be used to identify sepsis and other infections rapidly. By measuring differences in activated white cell counts such as neutrophils, the device of the present disclosure measures physiological response to infection in hospitalized patients recovering from burns, surgeries, etc.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: June 18, 2024
    Assignee: Texas Tech Univeristy System
    Inventor: Dimitri Pappas
  • Patent number: 10821441
    Abstract: A microfluidic device includes a substrate and a cover. The substrate has an inlet port, a first microchannel, one or more parking loops, a second microchannel and an outlet port for each microchannel network. The first microchannel is connected to the inlet port, the second microchannel is connected to the outlet port, the parking loops are connected between the first and second microchannels. Each parking loop includes a parking loop inlet, a parking loop output, a fluidic trap connected between the parking loop inlet and the parking loop outlet, and a bypass microchannel connected to the parking loop inlet and the parking loop outlet. The cover is attached to a top of the substrate and has an inlet opening and an outlet opening through the cover for each microchannel network. The inlet and outlet openings of the cover are disposed above the inlet and outlet ports in the substrate.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: November 3, 2020
    Assignee: Texas Tech Univeristy System
    Inventors: Siva A. Vanapalli, Swastika S. Bithi