Patents Assigned to Texas Tech University
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Publication number: 20250244307Abstract: Embodiments of the present disclosure pertain to computer-implemented methods of reconstructing a fiber length distribution of a fiber from its fibrogram by receiving the fibrogram; determining an end of the fibrogram; applying a windowed curve-fitting procedure to smoothen the fibrogram curvel and estimating the fiber length distribution of the fiber from the smoothened fibrogram curve. The methods may also include one or more steps of reconstructing an initial and missing portion of the fibrogram; assessing fiber quality based on the estimated fiber length distribution; adjusting one or more fiber-related conditions based on the estimated fiber length distribution; and repeating the method after the adjustment. Additional embodiments pertain to computing devices for reconstructing a fiber length distribution of a fiber from its fibrogram.Type: ApplicationFiled: April 4, 2023Publication date: July 31, 2025Applicant: Texas Tech University SystemInventors: Christopher Turner, Md Abu Sayeed, Eric Hequet
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Patent number: 12344632Abstract: Disclosed is a system and method for Fmoc/tBu solution-phase peptide synthesis including the development of a new benzyl-type GAP protecting group, and related uses thereto. This novel GAP protecting group is utilized in place of a polymer support, facilitating C to N Fmoc peptide synthesis without chromatography, recrystallization, or polymer supports. The GAP group can be added and removed in high yield.Type: GrantFiled: February 10, 2021Date of Patent: July 1, 2025Assignee: Texas Tech University SystemInventors: Guigen Li, Cole Seifert
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Patent number: 12338204Abstract: Disclosed is a composition and method for a therapeutic treatment that is able to combat triple negative breast cancers (TNBCs). The class of urea compounds acts by blocking at inhibiting the mTOR signaling pathway, which, as a central regulator of mammalian metabolism and physiology that when inhibited leads to the induction of autophagocytosis. The disclosed compounds are further capable of reinitiating the p53 cycle as well as inhibition of the BNIP3/BNIP3L pathway. The disclosed compounds also shows the ability to cross the blood-brain-barrier where metastases can form. This new drug has the potential to be a powerful new treatment to combat invasive TNBCs.Type: GrantFiled: August 9, 2019Date of Patent: June 24, 2025Assignee: Texas Tech University SystemInventors: Nadezhda German, Ruwein Zhang, Wei Wang, Constantinos Mikelis, Luca Cucullo
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Patent number: 12322921Abstract: Core-cladding planar waveguide (PWG) structures and methods of making and using same. The core-cladding PWG structures can be synthesized by hydride vapor phase epitaxy and processed by mechanical and chemical-mechanical polishing. An Er doping concentration of [Er] between 1×1018 atoms/cm3 and 1×1022 atoms/cm3 can be in the core layer. Such PWGs have a core region that can achieve optical confinement between 96% and 99% and above.Type: GrantFiled: March 12, 2020Date of Patent: June 3, 2025Assignee: Texas Tech University SystemInventors: Hongxing Jiang, Zhenyu Sun, Yaqiong Yan, Jing Li, Jingyu Lin
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Publication number: 20250172541Abstract: Embodiments pertain to a bioink operational to form an artificial bone. The bioink includes a plurality of bone-related cells. Additional embodiments pertain to an artificial bone that includes a plurality of bone-related cells; and a bioink of the present disclosure that is embedded with the cells. The artificial bone may be in the form of a three-dimensional structure that includes a plurality of channels operational to allow fluid flow through the artificial bone. Further embodiments pertain to methods of making an artificial bone by applying a plurality of bone-related cells and a bioink onto a surface such that the bioink becomes embedded with the cells and forms a three-dimensional structure with a plurality of channels.Type: ApplicationFiled: January 23, 2025Publication date: May 29, 2025Applicant: Texas Tech University SystemInventors: Sanjay K. Srivastava, Shreyas Gaikwad, Marina Curcic, Mohamed Eltokhy
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Patent number: 12295812Abstract: The present disclosure describes a self-sprayer device for self-administering an animal product to an animal and providing environmental enrichment to the animal.Type: GrantFiled: August 8, 2024Date of Patent: May 13, 2025Assignee: Texas Tech University SystemInventor: John J. McGlone
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Patent number: 12281145Abstract: This invention relates to a truncated dysferlin nucleic acid and protein, vectors (e.g., adeno-associated virus vectors) comprising the nucleic acid and methods of using the same for delivery of dysferlin to a cell or a subject and treating dysferlinopathy.Type: GrantFiled: June 16, 2017Date of Patent: April 22, 2025Assignees: The University of North Carolina at Chapel Hill, Texas Tech University SystemInventors: Matthew Louis Hirsch, R. Bryan Sutton
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Patent number: 12270152Abstract: The present invention includes a method for dissolving cellulose comprising dissolving cellulose in an ionic liquid and a co-solvent, wherein the ionic liquid is an imidazolium-based ionic liquid with, e.g., a halide or acetate as the anion.Type: GrantFiled: January 17, 2019Date of Patent: April 8, 2025Assignee: Texas Tech University SystemInventors: Noureddine Abidi, Edward Quitevis, Vidura D. Thalangamaarachchige, Niwanthi Dissanayake
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Publication number: 20250060318Abstract: Embodiments pertain to methods of evaluating fiber quality by (1) receiving at least one in-line hologram image of the fiber; (2) reconstructing the in-line hologram image of the fiber into at least one three-dimensional image of the fiber that includes fiber-related data; and (3) correlating the fiber-related data to fiber quality. Such methods may also include: (4) adjusting fiber-related conditions; and (5) repeating steps 1-3 after the adjustment. Further embodiments pertain to systems for evaluating fiber quality in accordance with the aforementioned methods. Such systems may include a receiving area with a region for housing a fiber, a light source associated with the receiving area, a chamber associated with the light source and receiving area, a camera within the chamber, a processor in electrical communication with the camera, a storage device, an algorithm associated with the storage device and a graphical user interface (GUI) associated with the processor.Type: ApplicationFiled: December 23, 2022Publication date: February 20, 2025Applicants: Texas Tech University System, University of ToledoInventors: Aniruddha Ray, Brendan Kelly, Hamed Sari-Sarraf
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Publication number: 20250041036Abstract: The present disclosure describes a self-sprayer device for self-administering an animal product to an animal and providing environmental enrichment to the animal.Type: ApplicationFiled: August 8, 2024Publication date: February 6, 2025Applicant: Texas Tech University SystemInventor: John J. McGlone
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Publication number: 20240407712Abstract: Embodiments pertain to a computer-implemented method of predicting muscle fatigue in a subject by: (1) receiving data related to muscle fatigue in a muscle of the subject; (2) feeding the data into an algorithm to predict the muscle fatigue; and (3) outputting the predicted muscle fatigue. The algorithm my include: (a) an active compartment (M_A) model representing individual motor units (MUs) generating force at full capacity, (b) a resting compartment (M_R) model representing inactive MUs capable of rapid activation into force production, (c) a centrally fatigued compartment (M_FC) model representing fatigued MUs due to a central mechanism dominant at zero or near-zero joint velocities, with rapid recovery, and (d) a peripherally fatigued compartment (M_FP) model representing fatigued MUs due to a peripheral mechanism dominant at higher velocities, with slow recovery. Further embodiments pertain to a computing device for predicting muscle fatigue in a subject in accordance with such methods.Type: ApplicationFiled: June 12, 2024Publication date: December 12, 2024Applicant: Texas Tech University SystemInventors: James Yang, Ritwik Rakshit
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Patent number: 12152564Abstract: Disclosed is a system and method for both consumer and utility scale energy extraction from flow-based energy sources. The passive system may utilize directing perforations on a surface in order to create and air jet vortex generators. Alternatively the system may provide for flow through discrete orifices aligned with the span of an aerodynamic assembly in a co-flow direction, utilizing a Coanda effect. Further additional configurations include directing flow through a perforated surface skin that is near the trailing edge on the suction side. Even further are embodiments for blowing air directly out of the trailing edge of an airfoil. The disclosed systems and methods support a wide variety of scenarios for fluid flow energy extraction, such as wind or water flow, as well as for related products and services.Type: GrantFiled: September 13, 2021Date of Patent: November 26, 2024Assignee: Texas Tech University SystemInventor: Carsten Hein Westergaard
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Publication number: 20240383855Abstract: Embodiments of the present disclosure pertain to methods of forming a co-crystallized composition by mixing a first molecule in a solid phase with a second molecule in a liquid phase to form a mixture, and then co-crystallizing the mixture to form the co-crystallized composition in the form of a crystalline solid. The mixing of the first and second molecules may occur through the utilization of mechanical force, such as milling. The co-crystallization of the first and second molecules may occur by adding a solvent to the mixture of the molecules and then evaporating the added solvent. The methods may also include a step of utilizing the co-crystallized composition as seed crystals to grow additional co-crystallized compositions. Further embodiments of the present disclosure pertain to the formed co-crystallized compositions.Type: ApplicationFiled: August 27, 2022Publication date: November 21, 2024Applicant: Texas Tech University SystemInventors: Kristin Hutchins, Jesus Daniel Loya
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Patent number: 12134962Abstract: Methods for optimization of liquid oil production by huff-n-puff in shale reservoirs to achieve an improved (and optimal) oil recovery factor. The process determines and utilizes the optimum huff and puff times, number of cycles and soaking time under practical operation and reservoir conditions. The huff time in the process is a period so long that the pressure near the wellbore reaches the set maximum injection pressure during the huff period. The puff time in the process is the time required for the pressure near the wellbore to reach the set minimum production pressure during the puff period. Soaking is typically not necessary during the huff-n-puff gas injection in shale oil reservoirs. The number of huff-n-puff cycles is determinable by the time in which the economic rate cut-off is reached.Type: GrantFiled: May 15, 2023Date of Patent: November 5, 2024Assignee: Texas Tech University SystemInventor: James J. Sheng
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Patent number: 12125638Abstract: High-frequency supercapacitors that can respond at kilohertz frequencies (AC-supercapacitors). The electrodes of the AC-supercapacitors include edge oriented graphene (EOG) electrodes or carbon nanofiber network (CNN) electrodes. The EOG electrodes are formed by utilizing a plasma and feedstock carbon gas to carbonize cellulous paper and deposit graphene implemented in one step. The CNN electrodes are formed by pyrolyzing a carbon nanofiber network utilizing a plasma.Type: GrantFiled: November 3, 2020Date of Patent: October 22, 2024Assignee: Texas Tech University SystemInventor: Zhaoyang Fan
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Publication number: 20240328084Abstract: Embodiments of the present disclosure pertain to methods of removing lignin from a material by associating the material with a deep eutectic solvent (DES) that includes at least one hydrogen bond acceptor (HBA) and at least one hydrogen bond donor (HBD). The methods of the present disclosure may also include one or more steps of heating the solvent-associated material, separating the material from the solvent, drying the material, washing the material, and/or processing the material. Additional embodiments of the present disclosure pertain to delignified materials that are formed in accordance with the methods of the present disclosure.Type: ApplicationFiled: March 30, 2024Publication date: October 3, 2024Applicants: Texas Tech University System, BastCore, Inc.Inventors: Julia L. Shamshina, Noureddine Abidi, Bibb C. Beale, III, Richard A. Bryant
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Patent number: 12105579Abstract: A system and method for automatically predicting and detecting a failure of a system or a component includes one or data sources, a data pipeline interface communicably coupled to the one or more data sources, one or more processors communicably coupled to the data pipeline interface and the one or more relational databases, and one or more devices coupled to the one or more processors. The data pipeline interface processes and stores the data in one or more relational databases. The one or more processors quantify, forecast and prognosticate a likelihood of future events using one or more predictive modules, and determine one or more options and impacts using a prescriptive module. The one or more devices provide the one or more options and impacts or implement the one or more options.Type: GrantFiled: April 13, 2018Date of Patent: October 1, 2024Assignee: Texas Tech University SystemInventor: Dy D. Le
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Patent number: 12097180Abstract: Provided herein are maternal neonatal pheromonal agents capable of reducing aggression and improving feeding behavior in a pig. Compositions comprising the pheromonal agents and methods of using the agents to reduce aggression and improve feeding behavior and weight gain in the pig are also provided.Type: GrantFiled: September 21, 2020Date of Patent: September 24, 2024Assignee: Texas Tech University SystemInventor: John J. McGlone
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Patent number: 12099516Abstract: An apparatus and method include: receiving a data set having two or more variables; receiving a selection of at least one of the two or more variables, an abstraction level and a visual feature; automatically generating and displaying a set of visual representations of the data set on the display; receiving a change in the selected variables, selected abstraction level, the selected visual feature, or a selection from various views; determining a visual representation recommendation based on the selected variable(s), selected abstraction level and the selected visual feature, the change in the selected variables, selected abstraction level, the selected visual feature, or the selected views; and automatically updating and displaying the set of visual representations of the data set on the display based the visual representation recommendation, and the change in the selected variables, selected abstraction level, the selected visual feature, or the selected views.Type: GrantFiled: September 11, 2020Date of Patent: September 24, 2024Assignee: Texas Tech University SystemInventors: Van Vung Pham, David C. Weindorf, Tommy Dang
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Patent number: 12097181Abstract: Provided herein are maternal neonatal pheromonal agents capable of reducing aggression and improving feeding behavior in a pig. Compositions comprising the pheromonal agents and methods of using the agents to reduce aggression and improve feeding behavior and weight gain in the pig are also provided.Type: GrantFiled: July 7, 2022Date of Patent: September 24, 2024Assignee: Texas Tech University SystemInventor: John J. McGlone