Abstract: The present invention provides methods and apparatuses for the continuous processing and solids handling in near-critical and supercritical fluids. The present invention also allows for treatment of the starting material with the near-critical or supercritical fluid. The remaining raffinate is then continuously transferred and may be collected in a barrier fluid.

Abstract: The present invention provides a means for the recovery of residual specialty oils from cake using a compressed solvent, preferably carbon dioxide. The present invention also allows for the cake to be toasted before extraction. The compressed solvent can be recycled and the process is continuous.

Abstract: The present invention provides a method and device for collecting and concentrating a desired compound from a chromatographic column exit stream. The collection chamber can be heated or cooled and washed in a forward or backward direction for efficient removal.

Abstract: The invention is directed to a process for preparing a pharmaceutical formulation containing two or more active pharmaceutical ingredients comprising: (a) contacting two or more active pharmaceutical ingredients with a supercritical fluid to form a supercritical fluid solution; and (b) separating the active ingredients from the supercritical solution to yield a powder precipitate. Preferably, the pharmaceutical formulation prepared according to the invention contains a combination of two anti-infective agents or two anticancer agents. The invention is further directed to a process for preparing a pharmaceutical formulation containing two or more active pharmaceutical ingredients comprising: (a) combining two or more active ingredients with a cosolvent to form a solution; (b) contacting the solution with a supercritical fluid; and (c) recovering the precipitate in a powder form.

Abstract: This invention relates to a refrigeration method and processes that employ a nontoxic and environmentally benign, oil-free refrigerant in a novel vapor-compression thermodynamic cycle that includes a means for enhancing cooling capacity and efficiency. A means of controlling of the process conditions and flow of the refrigerant are provided. The refrigerant in the invention in used in a transcritical cycle.