Abstract: Method, device, and system for identifying a model-based time dependent light scattering signature that includes receiving an experimental time dependent light scattering signature comprising experimental data descriptive of an average molecular weight of protein components in a solution over time. The method further includes identifying an Ansatz for evaluating the experimental time dependent light scattering signature, the Ansatz being an initial model-based time dependent light scattering signature, the initial model-based time dependent light scattering signature identifying at least one key variable. The method also includes adjusting the at least one key variable in the initial model-based time dependent light scattering signature until a final model-based time dependent light scattering signature is identified. In some instances, the final model-based time dependent light scattering signature identifies at least one protein aggregation mechanism.
Type:
Grant
Filed:
January 12, 2017
Date of Patent:
December 20, 2022
Assignees:
ADVANCED POLYMER MONITORING TECHNOLOGIES, INC., THE ADMINISTRATORS OF THE TULANE EDUCATION FUND
Abstract: Carbon with mesopores (about two to fifteen nanometers in average pore size) is made using sucrose as a source of carbon, and silica and phosphoric acid as templates for the mesopore structure in the carbon. A silica sol is prepared in a water/ethanol medium and sucrose is dispersed in the sol. Phosphoric acid may be added to the sol to control pore size in the mesopore size range. The sol is dried, carbonized, and the silica and phosphate materials removed by leaching. The residue is a mesoporous carbon mass having utility as a catalyst support, gas absorbent, and the like.
Type:
Grant
Filed:
May 24, 2007
Date of Patent:
February 22, 2011
Assignees:
GM Global Technolgy Operations LLC, Tulane University; Administrators of the Tulane Education Fund
Inventors:
Qingyuan Hu, Yunfeng Lu, Jing Tang, Mei Cai
Abstract: Titanium oxide (usually titanium dioxide) catalyst support particles are doped for electronic conductivity and formed with surface area-enhancing pores for use, for example, in electro-catalyzed electrodes on proton exchange membrane electrodes in hydrogen/oxygen fuel cells. Suitable compounds of titanium and a dopant are dispersed with pore-forming particles in a liquid medium. The compounds are deposited as a precipitate or sol on the pore-forming particles and heated to transform the deposit into crystals of dopant-containing titanium dioxide.
Type:
Application
Filed:
March 3, 2010
Publication date:
June 24, 2010
Applicants:
GM GLOBAL TECHNOLOGY OPERATIONS, INC., Administrators Of The Tulane Education Fund
Inventors:
Mei Cai, Yunfeng Lu, Zhiwang Wu, Lee Lizhong Feng, Martin S. Ruthkosky, John T. Johnson, Frederick T. Wagner
Abstract: The present invention provides methods for utilizing a form of optimized suspension culture to examine the infectivity of pathogenic organisms and agents in human cells and tissues. Also provided are methods using a rotating wall vessel to predict chemosensitivity of cells and tissues to toxins and chemotherapeutic agents. These culture conditions potentiate spatial colocalization and three-dimensional assembly of individual cells into large aggregates which more closely resemble the in vivo tissue equivalent. In this environment, dissociated cells can assemble and differentiate into macroscopic tissue aggregates several millimeters in size. These culture conditions allow for better cellular differentiation and formation of three-dimensional cellular aggregates, more efficient cell-to-cell interactions, the in in vivo-like exchange of growth factors and greater molecular scaffolding facilitating mechanical stability for cells.
Type:
Grant
Filed:
April 5, 2002
Date of Patent:
July 17, 2007
Assignees:
Department of Veterans Affairs, Administrators of the Tulane Education Fund
Inventors:
Timothy Grant Hammond, Cheryl Anne Nickerson
Abstract: The invention comprises a foot-operated control for controlling operation of a computer by providing an input to the computer, such as controlling the position and movement of the computer's cursor in response to movement of one or more of an operator's feet.
Type:
Grant
Filed:
March 5, 1997
Date of Patent:
November 17, 1998
Assignee:
Administrators of the Tulane Education Fund