Abstract: According to embodiments of the present invention, a method for demodulating a position error signal from a readback servo signal having a first frequency associated with a first servo track of a storage medium and a second frequency associated with a second servo track adjacent to the first servo track is provided. The method includes sampling the readback servo signal at successive time instants to provide a sequence of samples, computing a Discrete Fourier Transform based on the sequence of samples, and providing a measurement indicative of the position error signal based on the Discrete Fourier Transform. According to further embodiments of the present invention, a demodulator is also provided.

Abstract: The present invention relates to novel antimicrobial compounds, methods of their production as well as uses thereof.

Abstract: A catalyst composition is provided, which may be used for ring closing metathesis. In the composition, a catalyst is immobilized on a siliceous mesocellular foam support. A suitable catalyst for use in the composition is a Grubbs-type catalyst or a Hoveyda-Grubbs-type catalyst.

Abstract: We describe a method of expressing a recombinant protein comprising mannose-terminated N-glycans from a host cell, the method comprising: (a) introducing a nucleic acid encoding a recombinant protein into a Chinese Hamster Ovary (CHO) cell comprising a mutation in the GnT 1 gene (GenBank Accession Number AF343963) leading to loss of GnT 1 function; and (c) expressing the recombinant protein from the host cell, in which the expressed recombinant protein comprises a mannose-terminated glycan structure, and in which the method does not include a step of introducing functional GnT-1 into the host cell. The method may be used for producing recombinant glucocerebrosidase with a mannose-terminated glycan structure, suitable for treatment or prevention of Gaucher's Disease.

Abstract: According to embodiments of the present invention, a data storage device is provided. The data storage device includes a recording channel configured to carry a signal; a detector configured to detect the signal from the recording channel; and a noise prediction circuit configured to predict noise affecting the recording channel and the detected signal based on a noisy channel model. According to further embodiments of the present invention, a method of processing a signal in a data storage device is also provided.

Abstract: Various embodiments provide a method for collecting audience information of a group of users in an audience measurement. The method may include each user dividing its private information into a private portion and a predetermined number of exchange portions; each user transmitting each of its exchange portions to a respective user of the predetermined number of users selected from the group of users; each user aggregating its private portion and exchange portions received from other users of the group of users, thereby producing randomized information; and aggregating the randomized information of the group of users, thereby producing aggregated private information for the group of users.

Abstract: A method for encoding a digital signal into a scalable bitstream comprising quantizing the digital signal, and encoding the quantized signal to form a core-layer bitstream, performing an error mapping based on the digital signal and the core-layer bitstream to remove information that has been encoded into the core-layer bitstream, resulting in an error signal, bit-plane coding the error signal based on perceptual information of the digital signal, resulting in an enhancement-layer bitstream, wherein the perceptual information of the digital signal is determined using a perceptual model, and multiplexing the core-layer bitstream and the enhancement-layer bitstream, thereby generating the scalable bitstream.

Abstract: We describe a method of determining whether a cancer cell is likely to be resistant to treatment by an mTOR inhibitor. The method may comprise detecting PPP2R2B (GenBank Accession Number: NM_18167) in or of the cell. It may, alter-natively, or in addition, comprise detecting PDK1 (GenBank Accession Number: NM_002613), in or of the cell. The method may comprise detecting methylation of the PPP2R2B promoter in or of the cell. It may comprise detecting the expression and/or activity of PPP2R2B in or of the cell. It may comprise detecting PDK1 mediated Myc phosphorylation activity.

Abstract: Embodiments of the invention provides a method and device for assigning bitrates to a plurality of channels in a scalable audio encoding/truncation process. Different bitrates are assigned to different channels in the scalable audio encoding/truncation process.

Abstract: A sensor and a method of detecting a target analyte are provided. The sensor includes a substrate; a layer comprising a plurality of through holes, wherein the layer is disposed above the substrate; a first element configured to detect a target analyte; a second element that can produce a detectable signal; wherein the first element and the second element are configured to couple the target analyte between the first element and the second element.

Abstract: The disclosure relates to methods for screening candidate antibody molecules which bind to podocalyxin-like protein (PODXL) and/or to undifferentiated pluripotent stem cells and particularly, although not exclusively, to methods for identifying candidate cytotoxic antibody molecules.

Abstract: A method for measuring a change in a spacing between a head and a storage medium of a data storage system. The method includes obtaining a first readback signal from the storage medium using the head at a first spacing between the head and the storage medium, determining a first power spectrum density over a frequency range from the obtained first readback signal, obtaining a second readback signal from the storage medium using the head at a second spacing between the head and the storage medium, determining a second power spectrum density over the frequency range from the obtained second readback signal, and providing a measurement indicative of the change in the spacing based on the determined first power spectrum density and the determined second power spectrum density. A data storage system is also provided.

Abstract: The disclosure relates to methods of binding and identifying undifferentiated pluripotent stem cells and particularly, although not exclusively, to use of binding moieties which bind to PHB on the surface of undifferentiated pluripotent stem cells, such as PHB-binding peptides, and to methods for depleting undifferentiated stem cells from a sample.

Abstract: A heated reaction gas comprising methane is contacted with first and second catalysts to catalyze production of an aromatic hydrocarbon. The first catalyst is more active than the second catalyst for catalyzing aromatization of methane, and the second catalyst is more active than the first catalyst for catalyzing aromatization of ethane. A reactor for producing aromatic hydrocarbons from the reaction gas may have a conduit defining a reaction zone for the reaction gas to react therein, and the first and second catalysts may be disposed in the reaction zone.

Abstract: According to embodiments of the present invention, an optical arrangement is provided. The optical arrangement includes a support substrate; at least one optical fiber arranged on the support substrate; at least one waveguide arranged on the support substrate and adjacent to the at least one optical fiber; the at least one waveguide defining a light propagation direction; and at least one grin index lens arranged asymmetrically relative to the light propagation direction such that light is coupled from the at least one optical fiber through the at least one grin index lens to the at least one waveguide.

Abstract: A multiple quantum well (MQW) structure for a light emitting diode and a method for fabricating a MQW structure for a light emitting diode are provided. The MQW structure comprises a plurality of quantum well structures, each quantum well structure comprising: a barrier layer; and a well layer having quantum dot nanostructures embedded therein formed on the barrier layer, the barrier and the well layer comprising a first metal-nitride based material; wherein at least one of the quantum well structures further comprises a capping layer formed on the well layer, the capping layer comprising a second metal-nitride based material having a different metal element compared to the first metal-nitride based material.

Abstract: Techniques for differentiating isobaric species are described. An isobaric species may be substituted with a tagging species identified using mass spectrometry. The isobaric species may be a subunit of a first polymer having a defined sequence, e.g., the isobaric species may be an amino acid in a protein or a peptide sequence. A tagging species may be substituted for the isobaric species in a second polymer having an otherwise identical sequence as the first polymer. The second polymer may have the same number of sequences as the first polymer, and substantially the same sequence of subunits, with a few exceptions such as the tagging species for the isobaric species. The first polymer and the second polymer may be prepared in the same reaction vessel. A polymer/protein of defined subunit sequence containing an isobaric species or a tagging species may be analyzed by mass spectrometry to determine the sequence.

Abstract: According to embodiments of the present invention, a memory device with soft decision decoding is provided. The memory device includes a memory cell configured to store an input data bit; a memory sensor configured to read out a parameter associated with a state of the memory cell; a detector configured to determine, based on the parameter read out from the memory cell, a soft information indicating the likelihood that the input data bit stored in the memory cell is a “0” or the likelihood that the input data bit stored in the memory cell is a “1”; and a decoder configured to generate a decoded bit based on the soft information. Further embodiments relate to a method of performing soft-decision decoding on a data bit stored in a memory cell of a memory device.

Abstract: According to embodiments of the present invention, a magnetoresistance device is provided. The magnetoresistance device includes a hard magnetic layer and a soft magnetic layer arranged one over the other, wherein the soft magnetic layer includes a stack structure, the stack structure including a first layer and a second layer arranged one over the other, wherein the first layer has a first damping factor and the second layer has a second damping factor, the first damping factor is selected to be lower than the second damping factor.

Abstract: An interrogation circuit for a nanowire sensor array and a method for interrogating a nanowire sensor array are provided. The circuit comprises a switch array connected to the nanowire sensor array for selectively connecting first ends of nanowire sensors of the nanowire sensor array to a reference voltage; an integration amplifier (IA) connected to second ends of the nanowire sensors at a first input of the IA and to the reference voltage at a second input of the IA, for generating an oscillating output signal clamped between first and second voltage values; wherein the switch array is further arranged for switching one of the nanowire sensors to be connected in a closed loop with the IA such that a current through said one nanowire sensor periodically charges and discharges an integration capacitor of the IA for determining a resistance of said one nanowire sensor from a frequency of the periodic charging and discharging.