Abstract: Compounds, compositions and methods for the treatment of cancer are disclosed herein. Embodiments of the present invention include compounds having the formula: (I), wherein R1 is selected from hydrogen or substituted or unsubstituted (C1-C6) alkyl or (C3-C6) cycloalkyl, R2 and R3 are independently selected from hydrogen, substituted or unsubstituted (C1-C6) alkyl, (C4-C6) cycloalkyl, or taken together with the N atom to which they are attached form a 3-6 membered heterocycloalkyl, and n is 1-5. Embodiments of the present invention also include pharmaceutical compositions comprising compounds of Formula (I) or pharmaceutically acceptable salts thereof, and methods of treating cancer via the administration of such compounds to patients in need of such treatment.

Abstract: Sintering self-assemblies of calcined colloidal silica particles results in sintered colloidal crystals that are free of cracks that can be resolved using optical microscopy. The sintered colloidal crystals have significantly improved strength and durability, and withstand aggressive handling. Surface rehydroxylation of the sintered colloidal crystals enables subsequent chemical modification.

Abstract: A laser apparatus includes a first surface-emitting laser device having an active region including at least one group of two or more quantum wells configured to generate photons and having an internal mirror configured to reflect the generated photons, and first and second opposing end cavity mirrors optically coupled to each other via the internal mirror of the first surface-emitting laser device and arranged to reflect the photons generated by the first surface-emitting laser device back to the first surface-emitting laser device to form a standing wave having a single antinode coincident with said at least one group of two or more quantum wells.

Abstract: A cube corner retro-reflector that includes three mutually perpendicular reflecting planes arranged in a pyramidal configuration, wherein at least one of the reflecting planes has a non-isotropic surface causing a polarization state of a ray exiting the cube corner retro-reflector to be orthogonal or substantively orthogonal to a polarization state of a ray entering the cube corner retro-reflector for all linear polarization orientations.

Abstract: A method of selecting component values for an analog circuit includes identifying a cost function that evaluates similarity between an approximate frequency response function and a preferred frequency response function for at least one characteristic of the functions, determining the approximate frequency response function of the analog circuit based on an approximate component value, and changing the approximate component value based on a determined magnitude of similarity between the preferred frequency response function and the approximate frequency response function for the at least one characteristic. An impedance matching apparatus includes a mismatch detection circuit that produces a difference between source and load impedances, a match network controller that produces a control value based on the difference, and a reconfigurable varactor match network including at least one stub mounted varactor having a capacitance controlled by the control value to match the source and load impedances.

Abstract: The present invention relates to stabilized silica colloidal crystals. In particular, the present invention relates to silica colloidal crystals having improved mechanical strength and durability. The present invention also relates to methods of making stabilized silica colloidal crystals by direct bonding between nanoparticles or between a polymer and nanoparticles through a siloxane bond.

Abstract: An optical device that includes 1) a gain section having a plurality of core regions including dopant species configured to absorb incident radiation at a first wavelength and emit radiation at a second wavelength, and 2) at least one passive section attached to the gain section. The gain section and the at least one passive section comprise an optical cavity which selectively promotes in-phase light emission from the optical cavity. An alternative optical device which includes a gain section having a plurality of core regions including dopant species configured to absorb incident radiation at a first wavelength and emit radiation at a second wavelength, and 2) two passive sections attached to the gain section at opposite ends.

Abstract: A polymer coated nanoparticle containing a metallic core and a polymer shell encapsulating said metallic core is useful, for example, in magnetic tapes and supercapacitors.

Abstract: The present invention provides methods of inhibiting cadherins between Schlemm's canal cells, to a patient suffering from glaucoma as well as screening for substances that inhibit cadherins between the Schlemm's canal cells.

Abstract: A transportable gas sterilization unit having a chamber, a disposable gas generator utilizing chlorine dioxide as a sterilant, chemical quencher and a detector and a method of using the unit and to generate chlorine dioxide for medical instrument sterilization or disinfection. A two photon, photo-activated chlorine dioxide system and coatings utilizing chlorine dioxide as at least one sterilant material, and methods for coating medical instruments with the photo activated chlorine dioxide system.

Abstract: An optical data recovery system including an optical receiver configured to receive light reflected from an optical medium and produce modulated data, a processing unit configured to transform the modulated data into a series of transform coefficients respectively identifying frequencies of the modulated data at respective times, and the processing unit is configured to identify from the series of transform coefficients defect coefficients associated with positions in the modulated data where the modulated data is corrupted.

Abstract: Glycopeptides which are amphipathic and capable of crossing the blood-brain-barrier are provided. The glycopeptides are useful for treating a variety of neurological an behavioral disorders.

Abstract: An optical device including: a first transparent substrate; a first electrode disposed on the first transparent substrate; a first mirror disposed on the first electrode; a high electro-optic coefficient polymer or sol-gel material disposed on the first mirror; a second mirror disposed on the high electro-optic coefficient polymer or sol-gel material and at least partially sandwiching the sol-gel material between the first and second mirrors; a second electrode disposed on the second mirror; and a second transparent substrate disposed on the second electrode.

Abstract: Poling electro-optic polymers on an organically modified sol-gel cladding layer can enhance Pockel's coefficient by up to a factor of 2.5.

Abstract: Sintering self-assemblies of calcined colloidal silica particles results in sintered colloidal crystals that are free of cracks that can be resolved using optical microscopy. The sintered colloidal crystals have significantly improved strength and durability, and withstand aggressive handling. Surface rehydroxylation of the sintered colloidal crystals enables subsequent chemical modification.