Abstract: A beam steering apparatus including a first actuatable micromirror array (AMA) having a pitch, p, adapted to impart a modulation to a wavefront incident on the first AMA by a transition between a first state and a second state, wherein the first AMA has a transition time (T) between the first state and the second state, and at least one light source adapted to provide the incident wavefront having a duration, t, to the first AMA, where t?T. The AMA may be a MEMS device such as a digital micromirror array. The beam steering apparatus may constitute a portion of LIDAR system.

Abstract: A method for preparing 18F radiolabeled biomolecules and agents for 18F-PET imaging is disclosed herein. A perfluoroaryl-conjugated target tracer is synthesized and purified with temperature and solvent conditions that are mild for the tracer molecule. The purified perfluoroaryl-conjugated target tracer is then labeled with 18F using 18F salts within a short reaction time, and with temperature and solvent conditions that are mild for the tracer molecule. The method provides a quick and convenient process that maintains the biological activities of the target molecules. The radio-labeled biomolecules may be used as contrast agents for Positron Emission Tomography (PET).

Abstract: Various examples are provided related to amplified deformable mirrors (ADMs). In one embodiment, an ADM includes a deformable mirror and a flexible dielectric matrix deposited on a front side of the deformable mirror. A pathlength of a wavelength, ?0, of electromagnetic radiation passing through the dielectric matrix can be amplified by a distribution of dielectric particles embedded in the dielectric matrix.

Abstract: Features are described for a pellet dispenser. The pellet dispenser be implemented as a complex molded unit to fit within the home cage of laboratory animals (e.g., hanging from a wall of the cage or inside a food hopper of the cage). The pellet dispenser may be contained within the cage or otherwise attached to the cage so as not to take up additional floor space in the cage which should be allocated for the small laboratory animal. The pellets may be gravity or screw drive fed towards an ejector port. At prescribed times during the day, a prescribed number of pellets may be ejected into the animal cage. Additional components of the pellet dispenser include an ejector (e.g., a linear actuator) and pellet hopper.

Abstract: Viral promoters and compositions and methods of use thereof are provided. Compositions include viruses with impaired ability to reactivate from latency, and pharmaceutical compositions and method of use thereof. The genome of the viruses include one or more mutations that reduce expression from one or more promoters that regulate expression of viral genes during reactivation from latency. The mutation(s) are typically in a region of the viral genome that includes (i) promoter elements of the iP1 promoter of human cytomegalovirus, or the sequence of another virus corresponding thereto (e.g., an iP1 promoter homolog); (ii) promoter elements of the iP2 promoter of human cytomegalovirus, or sequence of another virus corresponding thereto (e.g., an iP2 promoter homolog); or (iii) a combination thereof. In some embodiments the virus encodes one or more heterologous antigens. The viruses can be used as vaccines to induce prophylactic and therapeutic immune responses in subjects in need thereof.

Abstract: Minimally invasive percutaneous methods, devices, and systems for placing guide wires in bones in a desired position and orientation and for facilitating the treatment of fractures such as but not limited to intertrochanteric fractures or other applications such as osteotomies. The methods, devices, and systems may allow for rapid and reproducible placement of a guide wire in a bone. Each degree of freedom may be controlled independently.

Abstract: A composition includes a reaction product of a mixture of elemental sulfur and at least a first ethylenically unsaturated compound comprising a hydroxyl or carboxyl group.

Abstract: Devices and systems for treating based on light therapy are disclosed. One example device includes an eyewear configured for placement in front of an eye to allow light to reach the eye, and one or more filters having transmission spectra within a range that approximately spans 450 to 570 nm associated with blue or green light. The one or more filters is configured to block light spectra outside of said range and to allow the blue or green light to reach the eye for administering light therapy to a subject exhibiting pain.

Abstract: A biopsy system for harvesting larger volumes of tissue as compared to standard core biopsy needles. The system has a needle with a lumen, an aperture disposed at the distal end of the needle and connected to the lumen, and a cutting mechanism adapted to cut tissue. When the needle is rotated after it is inserted into a target tissue, the cutting mechanism cuts from the tissue and directs the cut tissue portions into the lumen. Multi-bioimpedance measurements are used to guide a needle and direct the application of electricity for cauterizing tissue.

Abstract: A collinear T-cavity VECSEL system generating intracavity Hermite-Gaussian modes at multiple wavelengths, configured to vary each of these wavelengths individually and independently. A mode converter element and/or an astigmatic mode converter is/are aligned intracavity to reversibly convert the Gaussian modes to HG modes to Laguerre-Gaussian modes, the latter forming the system output having any of the wavelengths provided by the spectrum resulting from nonlinear frequency-mixing intracavity (including generation of UV, visible, mid-IR light). The laser system delivers Watt-level output power in tunable high-order transverse mode distribution.

Abstract: A tiled head-mounted display device, comprising: an optical component including a plurality of prisms with free-form surfaces, each prism being a wedge prism comprising a first optical surface, a second optical surface and a third optical surface; and a display component including a plurality of micro-displays, wherein the number of the micro-displays and the number of the prisms with free-form surfaces is identical. The tiled head-mounted display device according to the present invention is compact and light, provides wide field of view and high resolution, especially for the optical tiling head-mounted display device, the exit pupil planes of each display channels are coincident, thus avoiding pupil aberration and keeping exit pupil diameter and eye clearance same as the single ocular. There is no resolution variance throughout the entire field of view, thus preventing extra trapezoid distortion.

Abstract: Methods and systems are described that enable three-dimensional (3D) imaging of objects. One example system includes a light source that produces multiple light beams having specific spectral content and polarization states. The system also includes phase masks that modify the intensity or phase of the light, and projection optics that allow simultaneously projection of at least three fringe patterns onto an object having particular phase, polarization and spectral characteristics. The detection system includes a camera that simultaneously receives light associated with the at the fringe patterns upon reflection from the object, and a processing unit coupled to the camera unit that determines one or both of a phase or a depth information associated with the object. The system and associated methods can efficiency produce 2D images of the object and allow determination of characteristics such as surface profile. The disclosed systems and methods can be effectively implemented with moving objects.

Abstract: The present invention relates generally to a head-mounted projection display, and more particularly, but not exclusively to a polarized head-mounted projection display including a light engine and a compact, high-performance projection lens for use with reflective microdisplays.

Abstract: Systems and methods for computer-implemented patient assistance are disclosed. In certain embodiments, the invention contemplates receiving patient data from plurality of sensors at a patient computer, transmitting patient data to a server, monitoring and analyzing the patient data at the server, and outputting recommended actions from the server to a personnel computer. The recommended actions are calculated based on safety considerations, emotional considerations, and/or a patient's treatment plan.

Abstract: A method for measuring distorted illumination patterns and correcting image artifacts in structured illumination microscopy. The method includes the steps of generating an illumination pattern by interfering multiple beams, modulating a scanning speed or an intensity of a scanning laser, or projecting a mask onto an object; taking multiple exposures of the object with the illumination pattern shifting in phase; and applying Fourier transform to the multiple exposures to produce multiple raw images. Thereafter, the multiple raw images are used to form and then solve a linear equation set to obtain multiple portions of a Fourier space image of the object. A circular 2-D low pass filter and a Fourier Transform are then applied to the portions. A pattern distortion phase map is calculated and then corrected by making a coefficient matrix of the linear equation set varying in phase, which is solved in the spatial domain.

Abstract: The present disclosure is directed to systems and methods of collecting environmental and/or biometric information and/or data using a chronic monitoring apparatus that includes a wearable expandable support structure to wirelessly receive power via a wireless power transfer antenna disposed in, on, or about the wearable expandable support structure. The chronic monitoring apparatus includes power receiver circuitry, data transmission circuitry, sensor circuitry, and control circuitry. The wearable expandable support structure maintains close contact between at least a portion of the sensor circuitry and the wearer of the chronic monitoring apparatus without requiring the use of adhesives or other bonding agents. The chronic monitoring apparatus communicates the collected environmental and/or biometric information to external data collection circuitry.

Abstract: The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.

Abstract: A three-dimensional imaging system includes at least one light source, a circular or elliptical polarization beamsplitter, a detector arrangement and an image processor. The light source is configured to provide light in a first circular or elliptical polarization state onto an object to be imaged. The circular or elliptical polarization beamsplitter is arranged to spatially separate the light reflected from an object into a first reflected portion in the first polarization state and a second reflected portion in the second polarization state. The first and second circular or elliptical polarization states are orthogonal to one another. The detector arrangement detects at least the first reflected portion of the light and the image processor is configured to generate image information from the detected first reflected portion.

Abstract: Methods, devices and systems provide improved detection, sensing and identification of objects using modulated polarized beams. An example polarization sensitive device includes an illumination source, and a modulator coupled to the illumination source to produce output beams in which polarization states or polarization parameters of the output beams are modulated to produce a plurality of modulated polarized beams. The device further includes a polarization sensitive detector positioned to receive a reflected portion of modulated polarized beams after reflection from an object and to produce information that is indicative of modulation and polarization states of the received beams. The information can be used to enable a determination of a distance between the polarization sensitive device and the object, or a determination of a polarization-specific characteristic of the object.

Abstract: A heat recovery apparatus, system and method of using the same. The heat recovery apparatus includes a particulate inlet, a particulate distributor in fluid communication with the particulate inlet, a cavity in fluid communication with the particulate distributor, a plurality of pipes contained within the cavity and configured for transmission of a heat transfer fluid therethrough, and a particulate outlet in fluid communication with the cavity.