Abstract: A method of purifying a nanodiamond powder includes preparing the nanodiamond powder, heating the nanodiamond powder at between 450° C. and 470° C. in an atmosphere including oxygen, performing a hydrochloric acid treatment on the heated nanodiamond powder, and performing a hydrofluoric acid treatment on the nanodiamond powder obtained after performing the hydrochloric acid treatment.

Abstract: Described herein are DNA primer sequences designed for the determination of gene or transcript information from Anuran species, and which may be used in studies for developmental and/or toxicity testing and for environmental toxicology or ecological assessment. Also described herein is a rapid, sensitive, high-throughput assay useful for supporting potential risk assessment across vertebrate clades, and that is also useful for evaluation of complex contaminant mixtures.

Abstract: The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.

Abstract: Polarization based channeled images are optically demodulated to produce directly viewable images. A channeled image flux is converted to an unpolarized flux by a phosphor or other sensor, and the resulting converted flux is demodulated by modulating at a spatial frequency corresponding to a modulating frequency of the channeled image flux. After modulation, the converted flux is spatially filtered to remove or attenuate portions associated with the modulation frequency and harmonics thereof. The resulting baseband flux is then imaged by direct viewing, projection, or using an image sensor and a display.

Abstract: The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

Abstract: The invention encompasses method of using quantitative PCR to detect fungal organisms in clinical and environmental samples to generate standards that allow the quantification of fungal organisms in the samples.

Abstract: The disclosure provides methods for characterizing a prostate cancer sample by detecting expression of ERG, PTEN or both, changes in which relative to a normal control are shown herein to be correlated with prostate cancer capsular penetration and more aggressive forms of prostate cancer. Such methods are useful for the prognosis of prostate cancer capsular penetration and for making treatment decisions in patients with prostate cancer that has penetrated the capsule. Also provided are kits that can be used with such methods.

Abstract: Provided are modular volume holographic imaging system (VHIS) endoscopic systems, comprising: an endoscope attachment module having a microscope objective lens, a single or cascaded compensated relay system configured to preserve an optical wavefront for use with a single or multiplexed volume hologram to select wavefronts originating from different object depths, and a system aperture; and a handle module configured to be reversibly attachable for operative communication with the endoscope attachment module, and having a beam splitter; a relay having adjustable spacing for object space focus compensation, and a single or multiplexed volume hologram suitable in operation to select wavefronts originating from different object depths, and wherein the handle module is further configured for operative communication with an illumination source and imaging optics. Preferably, an illumination module and an imaging module are configured to be in operative, reversibly attachable communication with the handle module.

Abstract: The present invention encompasses a phototrophic microorganism with altered and controlled adhesive properties.

Abstract: A method of producing particles of materials includes, with a first substance that includes at least one component that is a gas at room temperature and atmospheric pressure, extruding or emulsifying the first substance into or in the presence of a second substance to create a bubble in which the first substance is encapsulated by the second substance and wherein at least some of the first substance is in a gaseous phase, and causing the first substance to condense to a liquid phase, which causes the bubble to transform into a droplet or emulsion. The droplet or emulsion so created is an activatable phase change agent that is stable at room temperature and pressure.

Abstract: The invention relates to methods for determining the source of hydrocarbons presented in the pores of a host rock or found in contaminated groundwater. The method includes the steps of (a) determining a first isotopic composition of boron and/or lithium in one or more components within a potential source rock sample, such as kerogen, clay, or water; (b) determining a second isotopic composition of boron and/or lithium in the hydrocarbons found within the pores of a host rock sample or in contaminated groundwater; and (c) comparing the first and second isotopic compositions to determine whether the potential source rock is the source of the hydrocarbons within the pores of the host rock or in contaminated groundwater.

Abstract: The present invention discloses a solution to accelerate control flow loops by utilizing the branch outcome. The embodiments of the invention eliminate fetching and execution of unnecessary operations and also the overhead due to predicate communication thus overcoming the inefficiencies associated with existing techniques. Experiments on several benchmarks are also disclosed, demonstrating that the present invention achieves optimal acceleration with minimum hardware overhead.

Abstract: A variable stiffness treadmill system having a variable stiffness mechanism, a split-belt treadmill, a counterweight system, and a body weight support for supporting an individual and varying the stiffness below the individual on the treadmill for research and rehabilitation.

Abstract: The present invention provides conjugated side-strapped phthalocyanines and methods for producing and using the same. In one particular embodiment, the conjugated side-strapped phthalocyanine is of the formula: where each of the substituents are defined herein.

Abstract: An apparatus is disclosed for rotating equipment, like solar panels, about an axis. Tension and compression members, in a rigid structure, are employed in the apparatus to minimize weight and to maximize stiffness. The rotating equipment is attached to the upper end of a rotatable elongated compression member, rotatably supported at its lower end by a tri-pod base comprising three additional compression members. Six tension members extending up from the tripod base hold a flange through which passes the rotatable elongated compression member. Lateral forces on the rotatable equipment are transmitted to the tripod base through the six tension members. The apparatus is configured such that wind forces and torques on the rotated equipment are transmitted by the apparatus to ground supports. Solar panels supported by the apparatus may be held at a fixed tilt angle, or an additional mechanism may be provided for rotational about a second orthogonal axis.

Abstract: A new construction of CP-ABE, named Privacy Preserving Constant CP-ABE (PPC-CP-ABE) that significantly reduces the ciphertext to a constant size with any given number of attributes is disclosed. PPCCP-ABE leverages a hidden policy construction such that the recipients' privacy is preserved efficiently. A Privacy Preserving Attribute Based Broadcast Encryption (PP-AB-BE) scheme is disclosed. PP-AB-BE is flexible because a broadcasted message can be encrypted by an expressive hidden access policy, either with or without explicit specifying the receivers. PP-AB-BE significantly reduces the storage and communication overhead. Also, PP-AB-BE attains minimal bound on storage overhead for each user to cover all possible subgroups in the communication system.

Abstract: A composition and method for targeted delivery of substances to the lower GI tract comprises a base or scaffold carrier to which a drug or prodrug is fixed or covalently attached. Compound, when taken orally travels through the GI tract of a patient to the lower GI where bacterial azo reductace enzymes cleave the bonds, releasing the drug or prodrug from the base or scaffold carrier permitting the delivery of the drug to the vicinity of a target cell type in the GI tract. The base or scaffold, which remains as a by-product passes out of the GI tract in the feces.

Abstract: A method for the in vivo production of 1,3-butadiene from 2,4-pentadienoate is described (FIG. 1). Enzymes capable of decarboxylating 2,4-pentadienoate to 1,3-butadiene have been discovered. Recombinant expression of these newly discovered enzymes has resulted in the engineering of microorganisms capable of producing 1,3-butadiene when cultured in the presence of 2,4-pentadienoate. 1,3-butadienoate is an important monomer used in the manufacturing of rubbers and plastics. This invention will help to enable the biological production of 1,3-butadiene from renewable resources such as sugar, for example.

Abstract: Provided herein are devices and methods for generating microfluidic gradients, including an array of unique microfluidic gradients within an array of microchannels. Fluids within conduits are mixed in an intersection region to generate a mixed flow stream in a source reservoir channel that provides a gradient that varies with axial distance from the intersection region. Microchannels having an inlet connected to the source reservoir channel are configured to provide a microfluidic gradient in the microchannel. An outlet end of the microchannel is connected to a sink reservoir channel. By varying the ratio of fluid flow rates from the fluid conduits, the microchannel gradients are tuned. In this manner, a large number of unique gradients or array of microfluidic gradients is provided, wherein the gradient can be any number of physical or chemical parameters, including concentrations and physical fluid properties.

Abstract: A triple sensor structured for simultaneous measurement of glucose, oxygen, and pH. The sensor components are in thin film states such as sensing films or membranes, with a glucose probe associated with emission of radiation in the blue part of the spectrum, an oxygen probe associated with radiation in red portion of the spectrum, and a pH probe—with a green portion of the spectrum. The optical probes are chemically grafted or immobilized in a suitable polymer matrix, alleviating the leaching of the probes from the matrix, improving the thin film sensing stability, and enabling the repeatable use of the same sensing films.