Patents Assigned to The Arizona Board of Regents
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Patent number: 11976274Abstract: Provided herein, are methods of identifying neoantigens for treating and preventing cancer. Also disclosed are methods and compositions for administering identified neoantigens for the treatment and prevention of cancer.Type: GrantFiled: March 28, 2022Date of Patent: May 7, 2024Assignee: Arizona Board of Regents on Behalf of Arizona State UniversityInventors: Stephen Albert Johnston, Luhui Shen
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Patent number: 11978466Abstract: Systems, methods, and apparatuses to restore degraded speech via a modified diffusion model are described. An exemplary system is specially configured to train a diffusion-based vocoder containing an upsampler, based on pairing original speech x and degraded speech mel-spectrum mT samples; train a deep convoluted neural network (CNN) upsampler based on a mean absolute error loss to match the estimated original speech {circumflex over (x)}? outputted by the diffusion-based vocoder by extracting the upsampler, generating a reference conditioner, and generating a weighted altered conditioner cTn?. The system further optimizes speech quality to invert non-linear transformation and estimate lost data by feeding the degraded mel-spectrum mT through the CNN upsampler and feeding the degraded mel-spectrum mT through the diffusion-based vocoder. The system then generates estimated original speech {circumflex over (x)}? based on the corresponding degraded speech mel-spectrum mT. Other related embodiments are described.Type: GrantFiled: May 27, 2022Date of Patent: May 7, 2024Assignee: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Jianwei Zhang, Suren Jayasuriya, Visar Berisha
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Patent number: 11976162Abstract: Solvent free epoxy systems are disclosed that can include a hardener compound H comprising: a molecular structure (R1—(Y1)n), wherein R1 is an ionic moiety, Y1 is a nucleophilic group, n is a between 2 and 10; and an ionic moiety A acting as a counter ion to R1; and an epoxy compound E comprising: a molecular structure (R2—Z1)n), wherein R2 is an ionic moiety, Z1 comprises an epoxide group, n is a between 2 and 10, and an ionic moiety B acting as a counter ion to R2. In embodiments, the epoxy compound E and/or the hardener H is comprised in a solvent-less ionic liquid. The systems can further include accelerators, crosslinkers, plasticizers, inhibitors, ionic hydrophobic and/or super-hydrophobic compounds, ionic hydrophilic compounds, ionic transitional hydrophobic/hydrophilic compounds, biological active compounds, and/or plasticizer compounds. Polymers made from the disclosed epoxy systems and their methods of use are described.Type: GrantFiled: February 18, 2020Date of Patent: May 7, 2024Assignee: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Cody Friesen, Jose Antonio Bautista-Martinez, Mykhaylo Goncharenko, Paul Johnson
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Patent number: 11976261Abstract: A bioproduct manufacturing system is disclosed. The system comprises a hollow-fiber primary membrane gas absorber comprising a shell side and a lumen, wherein the primary membrane gas absorber is configured to receive a carbonate salt-based solvent on the shell side and a gas mixture comprising oxygen, nitrogen, and carbon dioxide in the lumen, at least one runway algal cassette reactor-photobioreactor, and a growth medium circulating between the primary membrane gas absorber and the at least one runway algal cassette reactor-photobioreactor. The at least one runway algal cassette reactor-photobioreactor comprises at least one growth chamber coupled to and in fluid communication with a headspace channel so as to define and interior volume, a first condenser coupled to and in fluid communication with the headspace channel, and a harvest line in fluid communication with the at least one growth chamber and coupled to a filter.Type: GrantFiled: February 1, 2021Date of Patent: May 7, 2024Assignee: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Pierre C. Wensel, Henri Gerken
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Patent number: 11977047Abstract: This present disclosure is directed to a silver metal wire coated with silver sulfide reference electrode, the preparation via anodization of a silver metal wire in a sodium and/or potassium sulfide solution and use thereof, including test methods to measure corrosion in test articles such as metal pipes. The reference electrode exhibits good stability characteristics, including stability under high temperature conditions.Type: GrantFiled: August 30, 2021Date of Patent: May 7, 2024Assignee: Arizona Board of Regents on Behalf of the University of ArizonaInventors: Dominic Francis Gervasio, Kalin Denton, Gil-Pyo Kim, Vlad Alex Sasaran, Nicholas Michael McEvoy, Alexis Gray
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Patent number: 11978534Abstract: Systems, devices and methods for predicting binding on an array such as a peptide array. Certain methods utilize a peptide array having a plurality of peptides with one or more defined parameters and contacting the peptide array with a training sample containing one or more molecules of interest. Interactions between the plurality of peptides and the one or more molecules of interest are processed according to a data fitting model, which model is then is applied to interactions between the plurality of peptides and a test sample to predict binding associated with the one or more molecules of interest.Type: GrantFiled: July 9, 2018Date of Patent: May 7, 2024Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventor: Neal Woodbury
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Publication number: 20240144998Abstract: A system for in-memory computing comprises a volatile memory comprising at least a first layered subarray, wherein each subarray comprises a plurality of memory cells, and a plurality of sub-sense amplifiers connected to a read bitline of the first subarray of the memory, configured to compare a measured voltage of the read bitline to at least one threshold and provide at least one binary output corresponding to a logic operation based on whether the voltage of the read bitline is above or below the threshold. A method for in-memory computing is also disclosed.Type: ApplicationFiled: November 1, 2023Publication date: May 2, 2024Applicant: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Deliang Fan, Shaahin Angizi
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Publication number: 20240145036Abstract: A method of calculating an abundance of an mRNA sequence within a gene comprises storing an index table of the gene in a non-volatile memory, obtaining a short read of the mRNA sequence, generating a set of input fragments from the mRNA sequence, initializing a compatibility table in a volatile memory, for each input fragment in the set of input fragments, searching for an exact match of the input fragment in the index table, calculating a final result from the compatibility table, and calculating an abundance of the mRNA sequence in the gene by aggregating the transcripts compatible with the short read, wherein the calculating step is performed on the same integrated circuit as the non-volatile memory. A system for in-memory calculation of an abundance of an mRNA sequence within a gene is also disclosed.Type: ApplicationFiled: March 21, 2023Publication date: May 2, 2024Applicant: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Deliang Fan, Fan Zhang, Shaahin Angizi
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Patent number: 11970683Abstract: Disclosed herein are methods and systems for membrane carbonation for cultivating microalgae and other microorganisms that utilize a gaseous substrate, as well as to upgrade the quality of mixed-gas streams.Type: GrantFiled: March 4, 2020Date of Patent: April 30, 2024Assignee: Arizona Board of Regents on Behalf of Arizona State UniversityInventors: Bruce Rittmann, Everett Eustance, Yen-Jung Lai, Justin Flory, Diana Calvo Martinez, Tarun Shesh
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Patent number: 11969401Abstract: The disclosure provides methods for treating or limiting development age-related macular degeneration, comprising (a) a GPR143 receptor agonist, including but not limited to L-DOPA, L-DOPA analogues, or a pharmaceutically acceptable salt thereof, and (b) melatonin, a melatonin analogue, or a pharmaceutically acceptable salt thereof, and related compositions.Type: GrantFiled: January 30, 2020Date of Patent: April 30, 2024Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONAInventors: Robert Snyder, Brian McKay
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Patent number: 11970521Abstract: Peptide analogues of ?-amyloid and methods of using said analogues for neuroprotection are described herein. The ?-amyloid peptide analogues have a sequence that is at least 50% identical to an N-terminal ?-amyloid core fragment. A pharmaceutical composition of the ?-amyloid peptide analogues in a pharmaceutically acceptable carrier can be administered to a subject for neuromodulation. The ?-amyloid peptide analogues, while lacking neurotoxicity, effectively provides for protective activity against ?-amyloid toxicity.Type: GrantFiled: August 15, 2017Date of Patent: April 30, 2024Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, UNIVERSITY OF HAWAIIInventors: Robert A. Nichols, Kelly Forest, Victor J. Hruby
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Patent number: 11974495Abstract: Tetradentate platinum and palladium complexes based on biscarbazole and analogues for full color displays and lighting applications.Type: GrantFiled: July 19, 2021Date of Patent: April 30, 2024Assignee: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Jian Li, Zhi-Qiang Zhu
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Patent number: 11971410Abstract: Provided herein are methods for classifying how a subject having a cancer will respond to immunotherapeutic (IT) therapy based on the subject's immunosignature or frameshift signature. Also provided herein are methods for classifying a subject having a cancer as having a good prognosis or a poor prognosis based on the subject's immunosignature or frameshift signature.Type: GrantFiled: February 15, 2022Date of Patent: April 30, 2024Assignee: Arizona Board of Regents on behalf of Arizona State UniversityInventor: Stephen Johnston
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Patent number: 11973274Abstract: A single-switch-per-bit topology for reconfigurable reflective surfaces (RRSs) is provided. Novel multi-bit unit-cell configurations are presented for radio-frequency (RF) RRSs with improved radiation efficiency and compact designs. Embodiments described herein realize a multi-bit RRS using an antenna array with multiple integrated switches at the ports of every antenna element (e.g., one at each port, providing one control bit per switch). By manipulating the states of the switches, the impinging waves on the surface are modulated, leading to beamforming in the desired direction. Some embodiments utilize a single switch-per-bit topology integrating single-pole-single-throw (SPST) switches (e.g., PIN diodes) into the unit-cell design, achieving up to 4 bits of phase quantization with only 4 switches. The exhibited radiation efficiency of the multi-bit RRS is significantly improved compared to lower bit configurations.Type: GrantFiled: May 18, 2021Date of Patent: April 30, 2024Assignee: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Panagiotis Theofanopoulos, Georgios Trichopoulos
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Publication number: 20240133914Abstract: The present disclosure provides an optomechanical accelerometer that includes a first membrane having a first susceptibility; a second membrane having a second susceptibility that is greater than the first susceptibility; and at least one support member; wherein: the second membrane is supported above the first membrane by the at least one support member, such that the first and second membranes form at least a portion of an optical cavity.Type: ApplicationFiled: February 11, 2022Publication date: April 25, 2024Applicant: Arizona Board of RegentsInventors: DALZIEL WILSON, AMAN RAJENDRA AGRAWAL
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Publication number: 20240135256Abstract: A method of training a machine learning algorithm comprises providing a set of input data, performing transforms on the input data to generate augmented data, to provide transformed base paths into machine learning algorithm encoders, segmenting the augmented data, calculating main base path outputs by applying a weighting to the segmented augmented data, calculating pruning masks from the input and augmented data to apply to the base paths of the machine learning algorithm encoders, the pruning masks having a binary value for each segment in the segmented augmented data, calculating sparse conditional path outputs by performing a computation on the segments of the segmented augmented data, and calculating a final output as a sum of the main base path outputs and the sparse conditional path outputs. A computer-implemented system for learning sparse features of a dataset is also disclosed.Type: ApplicationFiled: October 24, 2023Publication date: April 25, 2024Applicant: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Jae-sun Seo, Jian Meng, Li Yang, Deliang Fan
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Publication number: 20240137040Abstract: A low-pass and band-pass delta-sigma (??) analog-to-digital converter (ADC) device for sensor interface is disclosed. The device includes a first stage comprising a low-resolution passive integrator-based noise-shaping successive approximation register (SAR) ADC and a second stage comprising a voltage-controlled oscillator (VCO)-ADC.Type: ApplicationFiled: October 19, 2023Publication date: April 25, 2024Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventor: Arindam SANYAL
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Publication number: 20240135219Abstract: A signal comprises a plurality of codewords associated with a set of codewords, each codeword comprising a plurality of symbols associated with a symbol constellation. Processing includes: mapping quantum states associated with symbols of a particular codeword of the signal to a plurality of input qubits, and applying quantum operations to the input qubits according to a quantum circuit for decoding the signal. The quantum operations comprise: controlled unitary multi-qubit operations performed on two or more qubits in a first set of qubits controlled based on two or more qubits in a second set of qubits, an initial quantum measurement performed on an initially measured qubit in the first set of qubits, at least one controlled unitary single-qubit operation performed on a post-measurement state associated with the initially measured qubit, and quantum operations that invert at least a portion of the operations in the plurality of controlled unitary multi-qubit operations.Type: ApplicationFiled: January 25, 2022Publication date: April 25, 2024Applicants: Arizona Board of Regents on Behalf of the University of Arizona, Duke UniversityInventors: Narayanan Rengaswamy, Kaushik Seshadreesan, Saikat Guha, Henry Pfister
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Patent number: 11967663Abstract: A multi junction solar cell includes one or more upper cells and a thin-film, polycrystalline, low-bandgap bottom cell. A single-junction solar cell includes a polycrystalline semiconductor thin film, wherein a bandgap of the solar cell is greater than 1.2 eV or less than 1.2 eV, and the solar cell is configured to receive light through two surfaces, such that the bottom cell has bifacial operation.Type: GrantFiled: June 14, 2021Date of Patent: April 23, 2024Assignee: Arizona Board of Regents on behalf of Arizona State UniversityInventor: Richard R. King
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Patent number: 11964384Abstract: A curved origami-based metamaterial includes a panel of material having a plurality of curved creases each disposed within a plane of the panel. The panel is configured to be folded along one of the plurality of creases, and the panel is also configured to be bent about an axis disposed outside the plane of the panel. Stiffness manipulation is configured to be achieved in situ by activating a different one of the plurality of curved creases.Type: GrantFiled: September 29, 2021Date of Patent: April 23, 2024Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Hanqing Jiang, Zirui Zhai