Patents Assigned to The Asan Foundation
  • Patent number: 11434527
    Abstract: The present invention provides a method for detecting mycoplasma, which can directly confirm whether a cell is infected with mycoplasma, by simultaneously amplifying DNA extracted from lysing a host cell infected with mycoplasma, and mitochondrial DNA in the cytoplasm of the host cell. According to the method of the present invention, by directly using the DNA inside the host cell, the DNA of mycoplasma bound around the nucleus of the host cell can be used as an amplification target, thereby increasing detection sensitivity. In addition, since the mitochondrial DNA inside the host cell is used as an amplification target of an internal control sample, whether the sample has been sampled in an appropriate amount can be confirmed in a convenient manner, and furthermore, by comparing the band size between the internal control sample and the mycoplasma DNA, the degree of mycoplasma infection can be quantitatively confirmed.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: September 6, 2022
    Assignees: The Asan Foundation, University of Ulsan Foundation for Industry Cooperation
    Inventors: Eun Ju Kang, Yeon Mi Lee
  • Patent number: 11049241
    Abstract: Disclosed is a method for the quantification of pulmonary vessels by lobe, the method including extracting, at extraction unit, pulmonary vessels based on a medical image, locating, at analysis unit, voxels of pulmonary vessels with respect to the surface of a lobe, and quantifying, at calculation unit, the extracted pulmonary vessels.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: June 29, 2021
    Assignees: Coreline Soft Co., Ltd., The Asan Foundation, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Donghoon Yu, Hyungi Seo, Joon Beom Seo, Nam Kug Kim
  • Patent number: 11037336
    Abstract: A method for processing an unmatched low-dose X-ray computed tomography (CT) image using a neural network and an apparatus therefor are provided. The method includes receiving a low-dose X-ray CT image and removing noise from the low-dose X-ray CT image using a unsupervised learning based neural network learned using unmatched data to reconstruct a routine-dose X-ray CT image corresponding to the low-dose X-ray CT image.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: June 15, 2021
    Assignees: The Asan Foundation, University of Ulsan Foundation for Industry Cooperation, Korea Advanced Institute of Science and Teclmoiogy
    Inventors: JongChul Ye, Eunhee Kang, Dong Hyun Yang, Joon Bum Seo, Hyun Jung Koo
  • Publication number: 20210115505
    Abstract: The present invention provides a method for detecting mycoplasma, which can directly confirm whether a cell is infected with mycoplasma, by simultaneously amplifying DNA extracted from lysing a host cell infected with mycoplasma, and mitochondrial DNA in the cytoplasm of the host cell. According to the method of the present invention, by directly using the DNA inside the host cell, the DNA of mycoplasma bound around the nucleus of the host cell can be used as an amplification target, thereby increasing detection sensitivity. In addition, since the mitochondrial DNA inside the host cell is used as an amplification target of an internal control sample, whether the sample has been sampled in an appropriate amount can be confirmed in a convenient manner, and furthermore, by comparing the band size between the internal control sample and the mycoplasma DNA, the degree of mycoplasma infection can be quantitatively confirmed.
    Type: Application
    Filed: May 17, 2019
    Publication date: April 22, 2021
    Applicants: The Asan Foundation, University of Ulsan Foundation for Industry Cooperation
    Inventors: Eun Ju KANG, Yeon Mi LEE
  • Publication number: 20190329066
    Abstract: The present invention relates to a body insertable device having an outer body being bent; and an inner body positioned inside the outer body, having an accommodation space in which the resource soured is accommodated, and being capable of rotating inside the outer body, wherein a radiation emission direction is continuously adjusted by rotation of the inner body.
    Type: Application
    Filed: June 19, 2017
    Publication date: October 31, 2019
    Applicants: National Cancer Center, Korea Institute of Radiological & Medical Sciences, The Asan Foundation, University of Ulsan Foundation for Industry Cooperation
    Inventors: Young Kyung LIM, Jung Won KWAK, Dae Yong KIM, Yeon Joo KIM, Joo Young KIM, Soon Ki MIN, Young Dae JUNG, Ho Jin JEONG, Sang Hyoun CHOI, Ui Jung HWANG
  • Publication number: 20190133173
    Abstract: The present invention relates to a composition using a SLIT-ROBO system for preventing or treating sarcopenia and, more specifically, to a composition comprising a gene selected from among slit1, slit2, slit3, robo1, robo2, and fragments thereof, or a protein expressed from the gene as an effective ingredient for preventing or treating a muscle disease or for improving muscular function.
    Type: Application
    Filed: June 8, 2017
    Publication date: May 9, 2019
    Applicants: The Asan Foundation, University Of Ulsan Foundation For Industry Cooperation
    Inventor: Jung Min KOH
  • Patent number: 10242293
    Abstract: Provided are a method and program for computing a bone age using a deep neural network. The method for computing a bone age using a deep neural network, including: receiving an analysis target image that is a specific medical image to compute the bone age; and analyzing the analysis target image by at least one computer using the deep neural network to compute the bone age. According to the present disclosure, since the bone age is computed by accumulating medical images of a specific race (particularly, Korean) and analyzing the same, it is possible to compute an accurate bone age that conforms to race.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: March 26, 2019
    Assignees: The Asan Foundation, Vuno, Inc.
    Inventors: Woo Hyun Shim, Jin Seong Lee, Yu Sub Sung, Hee Mang Yoon, Jung Hwan Baek, Sang Ki Kim, Hyun Jun Kim, Ye Ha Lee, Kyu Hwan Jung
  • Publication number: 20180369538
    Abstract: Provided is a catheter to be inserted into an object. The catheter includes a main body having a tubular shape and an expansion layer formed on an outer circumferential surface of the main body, and the expansion layer contains an expandable material which is expanded by contact with a liquid.
    Type: Application
    Filed: November 4, 2016
    Publication date: December 27, 2018
    Applicants: The Asan Foundation, AJOU University Industry-Academic Cooperation Foundation, University of Ulsan Foundation for Industry Cooperation
    Inventors: Deok Hee LEE, Ji Hoon SHIN, Seon Moon HWANG, Tae Il KIM, Ga Young LEE, Eun Joung KIM, Jin Ho YOON, Seng Yong CHUN, Ki Dong PARK, Yun Ki LEE
  • Patent number: 10058261
    Abstract: Provided is a non-invasive system for estimating an atrial signal, including a plurality of sensors to sense a surface electrocardiogram signal, a reference atrial signal generation unit to generate an estimated ventricular signal with respect to a R wave in an electrocardiogram signal from one sensor among the plurality of sensors, and to generate a reference atrial signal by subtracting the estimated ventricular signal from the electrocardiogram signal from the one sensor, and an atrial signal estimation unit to generate an estimated atrial signal by applying a constrained independent component analysis algorithm based on the reference atrial signal to the received surface electrocardiogram signal, and to estimate one of the estimated atrial signals as an actual atrial signal, and a method using the same.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: August 28, 2018
    Assignees: Korea Institute of Science and Technology, The Asan Foundation
    Inventors: Jong Min Lee, Yoha Hwang, Seung-Jong Kim, Kyoung Jae Kim, Hyeong-jin Jeon, Gi-Byoung Nam, Yong-Giun Kim
  • Patent number: 10007984
    Abstract: A method of quantifying a medical image is disclosed herein. The method of quantifying a medical image includes acquiring regions of interest based on a medical image; filtering the sizes of the acquired regions of interest using length scale analysis; classifying the regions of interest whose sizes have been filtered, according to the sizes of the regions of interest; and visualizing the regions of interest whose sizes have been filtered, so that the regions of interest whose sizes have been filtered are distinguished from each other in the medical image according to the sizes of the regions of interest.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: June 26, 2018
    Assignee: The Asan Foundation
    Inventors: Min Ho Lee, Nam Kug Kim, Joon Beom Seo
  • Patent number: 9996918
    Abstract: A method for distinguishing between pulmonary arteries and pulmonary veins and a method for quantifying blood vessels are disclosed. The method for distinguishing between pulmonary arteries and pulmonary veins includes: forming a set of pulmonary vessels for points corresponding to pulmonary vessels, wherein each of the points of the set of pulmonary vessels has weight information; forming a tree from the points of the set of pulmonary vessels by using the weight information; and distinguishing between the pulmonary arteries and the pulmonary veins by separating the tree into a plurality of regions. The method for quantifying blood vessels includes: extracting blood vessels as a three-dimensional set of voxels based on medical images of an organ; finding the voxels of blood vessels included in a region of interest of the organ; and quantifying length information of the blood vessels by using the found voxels.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: June 12, 2018
    Assignee: The Asan Foundation
    Inventors: Nam Kug Kim, Joon Beom Seo, Se Youn Park, Sang Min Lee
  • Patent number: 9815840
    Abstract: The present invention relates to a pyrrolopyridazine derivative represented by Formula 1 of the detailed description, or a pharmaceutically acceptable salt thereof. The compound according to the present invention and a pharmaceutically acceptable salt thereof can inhibit the activity of protein kinase(s), and thus are useful for preventing or treating diseases related thereto.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: November 14, 2017
    Assignee: The Asan Foundation
    Inventors: Tae Gon Baik, Won-Hyuk Jung, Seung In Kim, Seung Chan Kim, Sook Kyung Park, Su Yeon Jung, Seung Hee Ji, So Young Ki, Min Cheol Kim, Eun Young Lee, Eun Mi Hong
  • Patent number: 9752151
    Abstract: The present invention relates to a composition for treatment or metastasis suppression of cancers which includes a p34 expression inhibitor or activity inhibitor as an active ingredient. According to the present invention, the p34 protein knock-down causes monoubiquitination of PTEN and accordingly nuclear localization of PTEN is induced, as a result, an Akt pathway which is related to survival, proliferation, invasive properties and metastatic properties of tumors is inhibited, and thus there is an effect of significantly reducing clonogenic potential and tumor forming potential of various cancer cells which simultaneously express PTEN and NEDD4-1. Consequently, the p34 gene expression inhibitor or p34 protein activity inhibitor according to the present invention can be effectively used as a treatment agent or a metastasis suppression agent for cancers.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: September 5, 2017
    Assignees: The Asan Foundation, University of Ulsan Foundation for Industry Cooperation
    Inventors: Tae Won Kim, Dong Hoon Jin, Seung Woo Hong, Jai Hee Moon, Jae Sik Shin, Jin Sun Kim, Kyung Ah Jung, Jung Shin Lee, Eun Kyung Choi, Jae Lyun Lee, Yong Sang Hong, Kyu Pyo Kim, Ky Youb Nam, Bong Cheol Kim
  • Publication number: 20160302689
    Abstract: The present disclosure relates to a brain disease diagnosis service apparatus including at least: a receiving unit for receiving an image of a subject to be diagnosed; a preprocessing unit for estimating a transformation matrix in order to align a predetermined standard image with the image received by the receiving unit, and for applying the estimated transformation matrix to a predetermined standard brain region map, thereby generating an individual brain region map for the subject to be diagnosed; a feature point extracting unit for calculating a ratio occupied by brain lesions for each brain region in the individual brain region map, generated by the preprocessing unit, of the subject to be diagnosed, thereby extracting feature points; and a disability type determining unit for determining a disability type on the basis of the ratio of the brain lesions, calculated by the feature point extracting unit, for each brain region.
    Type: Application
    Filed: November 18, 2014
    Publication date: October 20, 2016
    Applicant: The Asan Foundation
    Inventors: Dong Wha KANG, Yong Hwan KIM
  • Patent number: 8927760
    Abstract: The present invention relates to colchicine derivatives expressed in chemical formula 1, or to pharmaceutically acceptable salts thereof, to a method for preparing said derivatives, and to a pharmaceutical composition comprising said derivatives. The colchicine derivatives according to the present invention exhibit superior immunomodulatory effects as compared with conventional immunomodulators or colchicines, and therefore can be valuably used as an immunomodulator for modulating an acute or chronic immune response in organ transplantation.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: January 6, 2015
    Assignee: The Asan Foundation
    Inventors: Duck Jong Han, Sung-eun Yoo, Jeehee Suh
  • Patent number: 8841085
    Abstract: Disclosed are a nanoparticle sensor for measuring protease activity, for protease imaging, and a method for preparing the same. More specifically, the present invention relates to a nanoparticle sensor for measuring protease activity in which a fluorophore- and a quencher-conjugated peptide substrate is conjugated to a biocompatible polymer nanoparticle. The peptide substrate is specifically lysed by a protease. The sensor according to the present invention is capable of inhibiting emission of fluorescence with high extinctive activity of the quencher on a fluorescent material. But strong fluorescence is specifically emitted only if the peptide substrate is lysed by a specific protease. Therefore, the sensor is especially useful as a method for screening a novel drug such as a protease overexpression inhibitor, and early diagnosis of incurable diseases and various diseases such as autoimmune diseases including cancer, osteoarthritis, rheumatoid arthritis and dementia.
    Type: Grant
    Filed: August 27, 2009
    Date of Patent: September 23, 2014
    Assignees: Korea Institute of Science and Technology, The Asan Foundation, Futurechem Co., Ltd.
    Inventors: Ick-Chan Kwon, Kui-Won Choi, Kwang-Meyung Kim, In-Chan Youn, Seul-Ki Lee, Kyeong-Soon Park, Dae-Hyuk Moon, Dae-Yoon Chi, Seung-Jin Lee, Seung-Jae Myung
  • Patent number: 8664230
    Abstract: The invention provides novel substituted pyridopyrimidines represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of the phosphoinositide 3? OH kinase family (PI3K) for the treatment of inflammatory diseases, cancer, cardiovascular diseases, allergy, asthma and autoimmune disorders.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: March 4, 2014
    Assignee: The Asan Foundation
    Inventors: Gilnam Lee, Chul Soo Lim, Han Won Cho, Jeongbeob Seo, Albert Charles Gyorkos, Suk Young Cho, Eun Kyung Choi, Choung Soo Kim, Jung Jin Hwang
  • Publication number: 20130190200
    Abstract: The present invention relates to a single nucleotide polymorphism (SNP) for predicting the sensitivity to an anticancer targeted therapeutic formulation, a polynucleotide containing the same, and a method for predicting the sensitivity to an anticancer targeted therapeutic formulation. According to the present invention, it is possible to predict the sensitivity of each individual to a certain anticancer targeted therapeutic formulation, using a small amount of a sample taken from a patient and thus to select a most suitable targeted therapeutic formulation over the entire duration of treatment for the patient.
    Type: Application
    Filed: December 8, 2010
    Publication date: July 25, 2013
    Applicants: Korea Research Institute of Bioscience and Biotechnology, The ASAN Foundation
    Inventors: Jin Cheon Kim, Yong Sung Kim, Seon Young Kim, Dong Hyung Cho
  • Patent number: 7847092
    Abstract: The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of primary or secondary organofluoro compound by reacting fluorine salt containing radioactive isotope fluorine-18 with primary or secondary alkyl halide or primary or secondary alkyl sulfonate in the presence of alcohol of Chemical Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.
    Type: Grant
    Filed: December 9, 2005
    Date of Patent: December 7, 2010
    Assignees: FutureChem Co., Ltd., The Asan Foundation
    Inventors: Dae Hyuk Moon, Dae Yoon Chi, Dong Wook Kim, Seung Jun Oh, Jin-sook Ryu