Abstract: A biomarker composition for predicting susceptibility to a therapeutic agent for neurofibromatosis by using Ras activity; and a pharmaceutical composition for preventing or treating neurofibromatosis, including a Ras activity inhibitor. The biomarker composition can accurately diagnose susceptibility to a therapeutic agent for neurofibromatosis by measuring the expression levels of a GTP-bound and activated Ras (Ras-GTP) protein and an activated p-ERK protein or a gene encoding the same in a biological sample of an individual. The pharmaceutical composition inhibits the activity of Ras proteins, and thus can be effectively used for the prevention or treatment of neurofibromatosis in which the activity of the Ras proteins is increased.

Abstract: The present invention relates to an apparatus and method for providing virtual reality-based eye movement exercise and visual perception training, wherein a dichoptic presentation is provided in consideration of the deviation of a user's eyeball so as to prevent additional damage to stereoscopic vision due to suppression, and is provided by adjusting the degree of difficulty by changing the locations of visual stimuli on the basis of the level of deviation and training capability of the user, thus making it possible for the user to not only receive training suitable for the user's condition, but also simultaneously undergo visual perception training including eye exercise (movement) training and stereoscopic perception recognition.

Abstract: An RF catheter for treating hypertrophic cardiomyopathy includes: a body part constituting a catheter body made of a flexible and soft material; and an intraseptal insertion part provided at a distal part of the body part and having one or more electrodes, a tapered tip gradually becoming thinner toward an end thereof, and a guidewire lumen therein, into which a guidewire is inserted, so that during hypertrophic cardiomyopathy treatment, the intraseptal insertion part is inserted into the interventricular septum along the guidewire. A method of treating hypertrophic cardiomyopathy by using an RF ablation catheter includes: i) positioning the guidewire to a hypertrophied septum through a coronary sinus and a septal vein; ii) transferring the RF ablation catheter to the hypertrophied septum; and iii) performing RF ablation by applying RF energy to the electrodes provided at an end part of the RF ablation catheter by using an RF generator.

Abstract: A SNP-based model for predicting the occurrence of irAEs induced by immunotherapy. The dbSNP database rs541169 and a single nucleotide polymorphism (SNP) site in the TMEM162 (FAM187B) gene are closely correlated with the occurrence of irAEs. The rs541169 can be advantageously used as a biomarker for predicting the occurrence of irAEs induced by immunotherapy or predicting responsiveness to immunotherapy.

Abstract: Disclosed are an open-top two-photon light sheet microscope and an operating method thereof. The open-top two-photon light sheet microscope is capable of obtaining high-depth imaging, high-contrast resolution, and double contrast based on a Bessel beam, and enables rapid three-dimensional imaging by continuously capturing tissue on a per-plane basis without an optical clearing process or a sectioning process, and an operating method thereof.

Abstract: A method for predicting the occurrence of immune-related adverse events (irAEs) induced by an HLA type-based cancer immunotherapy agent. The method involves determining copy number variations (CNVs) of the HLA gene, such as HLA-B exon 2 deficiency, or HLA alleles such as HLA-B*35:01, HLA-B*40:02, HLA-B*54:01, or detecting an allele of an HLA gene selected from HLA-B*35:01, HLA-B*40:02, and HLA-B*54:01, in a biological sample isolated from a subject, and treating the cancer immunotherapy-induced irAE in the subject by administering to the subject a corticosteroid or immunosuppressant.

Abstract: The present disclosure relates to a medical vibratory stimulation device comprising: a wearable part that is worn on a target site of the body; a plurality of vibration elements which are arranged in the wearable part to apply vibratory stimuli to the target site of the body; and a control unit which individually controls the plurality of vibration elements so that the plurality of vibration elements sequentially apply vibratory stimuli from the distal portion to the proximal portion of the target site of the body.

Abstract: The present invention relates to a monoclonal antibody which specifically binds to an EGF2 domain of colon cancer secreted protein-2 (CCSP-2), or an antigen-binding fragment thereof. The monoclonal antibody or the antigen-binding fragment thereof of the present invention specifically binds to the EGF2 domain of CCSP-2, and thus has significantly increased affinity compared with existing peptides specifically binding to CCSP-2 and further increased specificity compared with existing antibodies to CCSP-2. Therefore, in future, accurate diagnosis can be achieved by specific detection of CCSP-2 in the protein level.

Abstract: The present disclosure relates to a corneal endothelial tissue transplantation system for easily and precisely moving corneal endothelial tissue inserted into an anterior chamber of an eyeball. To this end, the corneal endothelial tissue transplantation system according to an embodiment of the present disclosure includes a tissue carrier to which cultured corneal endothelial tissue is attached and which is inserted into an anterior chamber of an eyeball, a magnetic field generation module including at least one magnetic field generator which generates a magnetic field for moving the tissue carrier, and a support plate which supports the magnetic field generator, and a user input module which receives an input signal for controlling the magnetic field generator from a user.

Abstract: The present invention relates to a method, a composition, and a kit for preoperative prediction of prognosis after liver cancer surgery at an early stage by detecting, in a blood sample obtained from a liver cancer patient prior to surgery, an SORD marker, or an SORD marker together with an AFP marker.

Abstract: The disclosure purposes to provide an optical coherence tomography (OCT)-based system for diagnosing a high risk lesion such as a vulnerable atheromatous plaque by using an artificial intelligence model through deep learning. A deep learning-based diagnostic method of diagnosing a high risk lesion of a coronary artery includes: acquiring an OCT image of a coronary artery lesion of a patient; extracting a first feature of a thin cap from the OCT image; setting a region of interest included in the OCT image on a basis of the first feature; and determining whether the region of interest includes a high risk lesion.

Abstract: A chimeric antigen receptor (CAR), including an antigen-binding domain, a CD8 or CD28 hinge domain, a DAP10 cytoplasmic domain, a 2B4 cytoplasmic domain, and a CD3z cytoplasmic domain, where the CAR is expressed in natural killer (NK) cells. A method for treating cancer, including administering a therapeutically effective amount of a composition containing a NK cell that expresses the CAR, or a therapeutically effective amount of a cellular therapeutic agent containing a NK cell that expresses the CAR, to a subject in need thereof.

Abstract: A tympanum image processing apparatus may comprise: a processor which extracts, from a tympanum image, a tympanum outline of the tympanum image and earwax region of the tympanum image by using a first machine learning model, obtains, on the basis of the tympanum outline of the tympanum image, a target image of the entire tympanum, a tympanum outline of the target image, and earwax region of the target image, and generates a transformed image in which an abnormal region of the target image is changed to a normal region; and a display which displays at least one of the transformed image and the target image so that a tympanum region of the transformed image is aligned at a position corresponding to the position of a tympanum region of the target image.

Abstract: An antibody derived from a cancer survivor and use thereof. More particularly, among antibodies derived from survivors of 5 or more years from breast cancer surgery, an antibody showing high binding strength to cancer cells and having an inhibitory effect on the growth and migration of cancer cells is selected to identify an antigen of the antibody. The antibody is then highly likely to contribute to the survival of cancer patients and unlikely to cause adverse effects upon administration, and thus, can be widely used clinically for preventing and treating cancer and inhibiting metastasis.

Abstract: Disclosed are a cognitive training providing apparatus and a method thereof. The cognitive training providing apparatus includes a display module, a memory that stores health status information of a trainee, pieces of multimedia content, and a plurality of training tasks, an input module that receives a response of the trainee, and a control module that selects first multimedia content corresponding to the health status information among the pieces of multimedia content, selects a first training task corresponding to the first multimedia content among the plurality of training tasks, organizes game content by placing the first training task in the first multimedia content, and performs a cognitive training operation by outputting the game content through the display module.

Abstract: Disclosed is a stereoscopic vision training providing apparatus including a display module, a memory including a first reference image, a second reference image, a plurality of training images, stereoscopic vision information, an input module that receives a response of a trainee, and a control module that outputs the first reference image to a first area of the display module, and outputs the second reference image to a second area of the display module, sets training coordinates based on a coordinate change signal for the first reference image and the second reference image, outputs the plurality of training images with different stereoscopic effects to the display module based on the training coordinates, and performs a stereoscopic vision training operation of receiving a selection response to a training image with a high stereoscopic effect.

Abstract: The present invention relates to a pharmaceutical composition including a CDK inhibitor and an ID2 activator for the prevention or treatment of bladder cancer, wherein based on the finding that: among CDK1-TFCP2L1 pathway targets associated with urothelial differentiation in bladder cancer cells, ID2 is a factor significantly correlating with the tumor grade of bladder cancer; an ID2 activator exhibits a therapeutic effect on bladder cancer; and the combined administration of CDK1 inhibitor and ID2 activator induces apoptosis of bladder cancer cells and significantly suppresses the invasiveness of cancer cells, compared to administration thereof alone, thereby exhibiting a therapeutic effect of remarkably suppressing the size and progression of bladder cancer, a composition comprising a CDK inhibitor and an ID2 activator and a method for combined administration thereof are provided as novel therapeutic means for the prevention or treatment of bladder cancer.

Abstract: A method of quantifying fluorescent dyes labeled on extracellular vesicles, including providing an extracellular vesicle molecule labeled with a fluorescence dye molecule, and determining a brightness of each of the extracellular vesicle molecule labeled with the fluorescence dye molecule and the fluorescence dye molecule through fluorescence correlation spectroscopy (FCS) of the extracellular vesicle molecule and the fluorescence dye molecule.

Abstract: The present disclosure relates to a cell culture device. An aspect of the present disclosure may include a culture medium supply unit including a base, a first reservoir disposed on the base and having an accommodation space, which accommodates the culture medium and has one surface in which a through hole through which the culture medium is discharged is formed, and a culture medium control member disposed to pass through the through hole and configured to control a flow of the culture medium discharged from the first reservoir.

Abstract: The present disclosure relates to a low-level laser therapy device using a light-emitting diode (LED) endoscope cap. One aspect of the present disclosure may include a catheter formed to extend so as to be inserted into a body of a patient and including an air insufflation part for stretching the mucosal folds of the duodenum of the patient, an endoscope cap having a through hole therein to allow the catheter to be inserted therethrough, a hood disposed in one region outside the endoscope cap and disposed such that at least one region thereof protrudes forward from the endoscope cap, and one or more LEDs disposed on each of the endoscope cap and the hood.