Patents Assigned to The Asan Foundation
  • Publication number: 20200121645
    Abstract: Disclosed is a composition and method for preventing, ameliorating or treating an EGFR-mutant non-small cell lung cancer including a c-Jun N-terminal kinase (JNK) activator as an active ingredient. The composition significantly reduces the level of EGFR in EGFR-mutant non-small cell lung cancer cells, inducing apoptosis. Therefore, the composition is suitable for preventing, ameliorating or treating non-small cell lung cancers in subjects in need thereof. Particularly, the composition is effective in treating and preventing non-small cell lung cancers, which are difficult to effectively treat and prevent with gefitinib or erlotinib. Also disclosed is a composition and method for inhibiting the resistance of a non-small cell lung cancer to an EGFR tyrosine kinase inhibitor including a c-Jun N-terminal kinase (JNK) activator as an active ingredient. The inhibitory composition effectively overcomes resistance to EGFR tyrosine kinase inhibitors.
    Type: Application
    Filed: February 13, 2019
    Publication date: April 23, 2020
    Applicants: THE ASAN FOUNDATION, University of Ulsan Foundation For Industry Cooperation
    Inventors: Jaekyoung SON, Jin Kyung RHO, Jae Cheol LEE
  • Patent number: 10624769
    Abstract: A hybrid stent includes multiple main cells aligned in a spiral shape and including multiple first link units which are aligned diagonally and spaced at a predetermined distance from each other and multiple second link units which connect adjacent first link units among the multiple first link units and are spaced at a predetermined distance from each other, and one or more open cells adjacent to the multiple main cells in a longitudinal direction and aligned in a spiral shape.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: April 21, 2020
    Assignees: CG BIO CO., LTD., THE ASAN FOUNDATION
    Inventors: Han Ki Kim, Hyun Seung Ryu, Jun Hyuk Seo, Jun Kyu Park, Seok Beom Song, Chang Hun Kum, Jae Hwa Cho, Gyu Hyun Jin, Deok Hee Lee, Seon Moon Hwang, Tae Il Kim, Ok Kyun Lim, Ga Young Lee
  • Patent number: 10610088
    Abstract: There is disclosed a multi-wavelength endoscopic system for imaging an observation site labeled with a plurality of fluorescent materials having different colors. The system includes an imaging unit configured to acquire image data by polarizing incident light reflected from the observation site in a first direction and a second direction perpendicular to the first direction, dividing a spectrum region of the incident light polarized in the first direction and the second direction into a plurality of spectrum channels and measuring the intensity of light for each of the spectrum channel. The system further includes a computing unit configured to store a single fluorescence spectrum extracted from sample image data obtained by single-treating the observation site with each of the fluorescent materials and configured to separate and output the image data obtained in the imaging unit using the single fluorescence spectrum so that each of the fluorescent materials is displayed separately.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: April 7, 2020
    Assignee: THE ASAN FOUNDATION
    Inventors: Seung-Jae Myung, Sang-Yeob Kim, Sang Mun Bae, Eun-Ju Do, Dong-Jun Bae
  • Publication number: 20200093376
    Abstract: The present disclosure relates to a method, an apparatus and a computer program for noninvasively determining a cause of a blood pressure change. The method includes at least: obtaining maximum amplitudes of heart sounds; monitoring changes in the maximum amplitudes; estimating change amounts of indexes on a myocardial contractile force and on vascular resistance, based on increasing or decreasing of a blood pressure of the patient, and the changes in the maximum amplitudes; and determining the cause of the blood pressure change of the patient as an effect of at least one of alpha action, alpha blockage, beta action and beta blockage, based on results of the estimation of the first change amount of the first index, the second change amount of the second index and the third change amount of the third index.
    Type: Application
    Filed: November 27, 2019
    Publication date: March 26, 2020
    Applicants: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Sung Hoon KIM, Young Jin MOON, Gyu Sam HWANG
  • Publication number: 20200046357
    Abstract: A stent for anastomosis of different kinds of organs includes a main body, and at least one fixing unit provided in the main body. At least a portion of the main body is inserted into one of different kinds of organs to be anastomosed with each other, and the rest of the main body is inserted into the other of the different kinds of organs. A distance between the different kinds of organs under the anastomosis is maintained by the fixing units.
    Type: Application
    Filed: April 27, 2018
    Publication date: February 13, 2020
    Applicants: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Song-Cheol KIM, Chang Mo HWANG, In Kyong SHIM, Jung-Hoon PARK
  • Publication number: 20200038063
    Abstract: The present disclosure relates to an apparatus for closed reduction of a bone fracture. The apparatus includes at least: a pulling adaptor including: a handle configured to be gripped by an operator; an insertion rod that is extended from the handle in a longitudinal direction of the handle, and configured to be inserted into the bone fracture which is depressed in at least one area thereof; and a pulling lug that is bent and extended from an end of the insertion rod such that a longitudinal direction of the pulling lug is perpendicular to a longitudinal direction of the insertion rod or such that the pulling lug is inclined with respect to the insertion rod, the pulling lug being configured to be inserted into the at least one depressed area of the bone fracture, in order to pull the bone fracture.
    Type: Application
    Filed: October 9, 2019
    Publication date: February 6, 2020
    Applicants: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Jae Soon CHOI, Young Jin MOON, Jong Woo CHOI, Woo Shik JEONG, Ho Yul LEE
  • Patent number: 10532225
    Abstract: Disclosed is a tumor surface dose enhancing radiotherapy apparatus using a magnetic field, including a radiation beam generating unit that irradiates a radiation beam towards a tumor of a patient, a magnetic field generating unit that forms a magnetic field that is parallel to the radiation beam between the radiation beam generating unit and the tumor of the patient, and a control unit that controls a surface dose of the tumor by adjusting an intensity and an effective area of the magnetic field of the magnetic field generating unit.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: January 14, 2020
    Assignee: THE ASAN FOUNDATION
    Inventors: Jung Won Kwak, Nurihyun Jung, Byung Chul Cho, Seung Do Ahn, Sang Wook Lee, Jae Beom Bae
  • Patent number: 10525151
    Abstract: A method for preparing a radiopharmaceutical and, specifically, a method for preparing an organic fluoride-aliphatic compound usable as a radiopharmaceutical, a method for purifying the prepared organic fluoride-aliphatic compound, and a method for preparing a radiopharmaceutical by using a cassette comprising a backdraft preventing reaction container. A method for preparing an organic fluorinated aliphatic compound includes allowing a fluorine salt to react with a leaving group-containing aliphatic compound by using a multifunctional solvent represented by the following Chemical Formula 1 to obtain an aliphatic compound labeled with [18F] fluoride substituting for the leaving group. The organic fluoride-aliphatic compound can be prepared and purified through even a simple process at high yield, high efficiency, and high purity, and the radiopharmaceutical can be safely prepared without damage to a synthetic apparatus.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: January 7, 2020
    Assignee: THE ASAN FOUNDATION
    Inventors: Sang-ju Lee, Seung-jun Oh, Dae-hyuk Moon, Jin-sook Ryu, Jae-seung Kim, Jong-jin Lee
  • Publication number: 20190371203
    Abstract: The inventive concept relates to an endoscopic procedure simulator module and an endoscopic procedure simulator using the same. The endoscopic procedure simulator module according to the inventive concept includes a lesion indicating part having a discharge hole formed therein, through which a fluid is discharged to present a bleeding state, a module body to which the lesion indicating part is coupled, the module body having a fluid channel and a spacing space formed therein, in which the fluid to be discharged through the discharge hole flows through the fluid channel and the spacing space is separated from the fluid channel, and a diaphragm provided in the spacing space of the module body so as to be expandable, in which the diaphragm is expanded by a separate fluid injected into the spacing space and closes the discharge hole of the lesion indicating part.
    Type: Application
    Filed: July 19, 2019
    Publication date: December 5, 2019
    Applicants: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Ji Yong AHN, Gin Hyug LEE
  • Publication number: 20190351187
    Abstract: The present disclosure relates to a catheter delivery device having an improved mechanism for inserting a catheter into a blood vessel of a patient. The catheter delivery device includes at least: a body including a delivery path of a catheter; a pair of feeders having grippers located on the delivery path of the body and are configured to grip and release the catheter; and a rotator configured to rotate the catheter gripped by the feeders. The feeders move from a grip position where the grippers grip the catheter to a forward position where the grippers advance in a state of gripping the catheter, from the forward position to a grip release position where the grippers release the catheter, from the grip release position to a backward position where the grippers retract in a state of releasing a grip on the catheter, and from the backward position to the grip position.
    Type: Application
    Filed: August 2, 2019
    Publication date: November 21, 2019
    Applicants: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Jae Soon CHOI, Young Jin MOON, Gi Byoung NAM, Young Hak KIM, Zhenkai HU, Hoyul LEE
  • Publication number: 20190351190
    Abstract: The present disclosure relates to a catheter and a surgical medical device. The catheter includes at least: a first elastic member positioned at an end portion of the catheter, a second elastic member connected with the first elastic member, the second elastic member being curved with a first radius of curvature to protrude toward a first direction; a first wire connected with a first surface of the first elastic member, and configured to pull the catheter to bend the catheter in the first direction; a second wire connected with a second surface of the first elastic member, which is opposite to the first surface, and configured to pull the catheter to bend the catheter in a second direction; and a tube containing the first elastic member, the second elastic member, the first wire, and the second wire.
    Type: Application
    Filed: August 2, 2019
    Publication date: November 21, 2019
    Applicants: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Jae Soon CHOI, Young Jin MOON, Gi Byoung NAM, Young Hak KIM, Zhenkai HU, Hoyul LEE
  • Patent number: 10478069
    Abstract: Disclosed is a method for estimating an onset time of an infarct region based on brain images, the method including: obtaining brain images; extracting from the infarct region included in the brain images a set of quantitative values that vary according to the onset time of the infarct region; and having the set of quantitative values correspond to the onset time of the infarct region by applying a corresponding relation prepared therefor.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: November 19, 2019
    Assignee: THE ASAN FOUNDATION
    Inventors: Nam Kug Kim, Dong Wha Kang
  • Publication number: 20190329066
    Abstract: The present invention relates to a body insertable device having an outer body being bent; and an inner body positioned inside the outer body, having an accommodation space in which the resource soured is accommodated, and being capable of rotating inside the outer body, wherein a radiation emission direction is continuously adjusted by rotation of the inner body.
    Type: Application
    Filed: June 19, 2017
    Publication date: October 31, 2019
    Applicants: National Cancer Center, Korea Institute of Radiological & Medical Sciences, The Asan Foundation, University of Ulsan Foundation for Industry Cooperation
    Inventors: Young Kyung LIM, Jung Won KWAK, Dae Yong KIM, Yeon Joo KIM, Joo Young KIM, Soon Ki MIN, Young Dae JUNG, Ho Jin JEONG, Sang Hyoun CHOI, Ui Jung HWANG
  • Publication number: 20190302116
    Abstract: Provided are a method of testing NK cell activity, including: specifically stimulating at least two distinguishable factors on NK cells in a sample; measuring a synergistic activation level of the NK cells; and comparing the synergistic activation level of the NK cells with that of normal NK cells, and a composition for testing NK cell activity. In addition, the present disclosure relates to a kit for diagnosing an NK cell synergistic activity-associated disease, the kit including the composition.
    Type: Application
    Filed: March 17, 2017
    Publication date: October 3, 2019
    Applicant: THE ASAN FOUNDATION
    Inventors: Hun Sik Kim, Seung Jae Myung, Song Cheol Kim
  • Publication number: 20190274732
    Abstract: The present disclosure relates to a tool for a closed reduction of a fracture. The tool includes at least: a winding portion having a winding shape; a support extending from the winding portion in a normal direction relative to a plane of the winding shape; and a handle extending from the support in the normal direction, and configured to be gripped.
    Type: Application
    Filed: May 28, 2019
    Publication date: September 12, 2019
    Applicants: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Jae Soon CHOI, Young Jin MOON, Jong Woo CHOI, Ho Yul LEE
  • Publication number: 20190269359
    Abstract: The present disclosure relates to a system and a method for estimating an acute cerebral infarction onset time. The method according to the present disclosure includes at least: receiving a first image and a second image of a first patient whose acute cerebral infarction onset time is not identified; extracting an infarction area image from the second image; aligning the second image with the first image; defining an infarction area in the first image, based on a result of the alignment of the second image with the first image; extracting feature information of the first patient, from the infarction area in the first image; comparing the extracted feature information with reference data; and calculating an amount of time that has elapsed since the acute cerebral infarction onset time, based on a result of the comparison of the extracted feature information with reference data.
    Type: Application
    Filed: May 20, 2019
    Publication date: September 5, 2019
    Applicants: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Namkug KIM, Hyun Na LEE, Sung Won HAM, Dong Wha KANG
  • Publication number: 20190269460
    Abstract: The present invention relates to a customized surgical guide device and a customized surgical guide generating method and program. A customized surgical guide generating method comprises the steps of: acquiring body surface data and treatment area data from medical image data by a computer; a first shape data generating step, wherein the first shape data is data which corresponds to the shape of the body part cover; a target point setting step of setting one or more target points; setting individual first points on the body surface accessible to the target point with a medical tool; setting a guide tube length on the basis of a distance from the first point to the target point; and generating final shape data in which one or more guide tubes are combined to the first shape data by applying the guide tube length to the first point.
    Type: Application
    Filed: May 16, 2019
    Publication date: September 5, 2019
    Applicants: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Namkug KIM, Guk Bae KIM, Beom Seok KO, Sang Wook LEE, Sei Hyun AHN, Byung Ho SON, Jong Won LEE
  • Publication number: 20190262087
    Abstract: Provided are a device for driving a robot joint using a wire, an endoscope robot device including the same, and a medical robot device including the same. The device for driving a robot joint includes at least: a base; a first link coupled with the base, and configured to be rotatable relative to the base; a second link coupled with the first link, and configured to be rotatable relative to the first link; a plurality of wires positioned opposite each other, and configured to generate motions of the first and second links; and a wire drive device configured to drive the plurality of wires. Each of the plurality of wires is fixed, via the second link, on one of the base and the first link. Positions where the plurality of wires are fixed are asymmetrical to each other and have different heights to each other.
    Type: Application
    Filed: May 15, 2019
    Publication date: August 29, 2019
    Applicants: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Young Jin MOON, Jae Soon CHOI, Hoyul LEE
  • Patent number: 10392344
    Abstract: The present invention relates to a method for labelling fluorine-18, which is a radioisotope, and more specifically, to a method for labelling a [18F]fluoride in a method for preparing an organic [18F]fluoro compound by reacting an alkyl halide or an alkyl sulfonate with a [18F]fluoride, wherein a [18F]fluoride supported on a quaternary alkyl ammonium polymer support is eluted using a solution containing a metal salt or a quaternary ammonium salt with an adjusted pH, and a base is not additionally used. The present invention enables a labeling reaction without an additional base after precisely reflecting the concentration of a base absolutely necessary for the nucleophilic substitution of a [18F]fluoride or eluting a [18F]fluoride using a [18F]fluoride eluent with an adjusted pH, thereby stably obtaining a [18F]fluoride-labelled compound in a high yield, and is thus useful for production of fluorine-18-labelled radioactive medical supplies.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: August 27, 2019
    Assignee: THE ASAN FOUNDATION
    Inventors: Sang Ju Lee, Seung Jun Oh, Dae Hyuk Moon, Jin Sook Ryu, Jae Seung Kim, Jong Jin Lee
  • Publication number: 20190217046
    Abstract: Disclosed are a device, a method, and a program for training memory using brain stimulation. The method includes at least: displaying a first problem on a task display portion of a screen; receiving a first response corresponding to the first problem; and evaluating a memory state of a user based on the first response. The first problem includes one or more output images to be displayed at a specific location within the task display portion, and the first response includes a result of comparing a previous first problem that was displayed before N times (N is a natural number) of executing the method, with the displayed first problem.
    Type: Application
    Filed: March 25, 2019
    Publication date: July 18, 2019
    Applicants: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Dong Wha KANG, Dong Ho KIM