Abstract: The present invention relates to the therapeutic use of the carboxy-terminal domain of the heavy chain of the tetanus toxin for the treatment of amyotrophic lateral sclerosis (ALS).
Type:
Grant
Filed:
April 5, 2010
Date of Patent:
February 3, 2015
Assignees:
University of Zaragoza, Autonomous University of Barcelona
Inventors:
María Moreno Igoa, Ana Cristina Calvo Royo, Maria Jesús Muñoz Gonzalvo, Maria Pilar Zaragoza Fernández, Rosario Osta Pinzolas, José Aguilera Avila
Abstract: The present invention relates to the therapeutic use of the encoding sequence of the carboxy-terminal domain of the heavy chain of the tetanus toxin and of the polypeptide encoded by said sequence, preferably for the treatment of amyotrophic lateral sclerosis (ALS).
Type:
Application
Filed:
April 5, 2010
Publication date:
October 14, 2010
Applicants:
UNIVERSITY OF ZARAGOZA, AUTONOMOUS UNIVERSITY OF BARCELONA
Inventors:
Maria Moreno Igoa, Ana Cristina Calvo Royo, Maria Jesús Muñoz Gonzalvo, Maria Pilar Zaragoza Fernández, Rosario Osta Pinzolas, José Aguilera Avila
Abstract: A transgenic mouse containing an IGF-1 transgene which is operably linked to a promoter sequence and is expressed in the pancreas of the mouse.