Abstract: The present invention comprises a humanized monoclonal antibody that binds to the chemokine receptor CCR4. This antibody is derived from Mab 1567 and recognizes the same epitope. Binding of the invented antibody to CCR4 inhibits ligand-mediated activities and is used to treat symptoms of cancer. Moreover, the antibody is used in combination with vaccines to suppress the activity of regulatory T cells.
Type:
Grant
Filed:
December 29, 2008
Date of Patent:
February 24, 2015
Assignees:
Dana-Farber Cancer Institute, Inc., The Bingham and Women's Hospital
Inventors:
Wayne Marasco, Jianhua Sui, Quan Zhu, Thomas Kupper
Abstract: Methods and products for inducing IL-2 secretion, inducing IL-10 secretion, activating T cells, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. The methods of the invention are accomplished using an immunomodulator which is a polymer having at least two repeating charge motifs separated by at least a certain minimum distance.
Type:
Grant
Filed:
May 19, 2004
Date of Patent:
April 11, 2006
Assignee:
The Bingham and Women's Hospital, Inc.
Inventors:
Arthur O. Tzianabos, Dennis L. Kasper, Andrew B. Onderdonk, Julia Ying Wang