Patents Assigned to The Biotechnology Research & Development Corp.
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Publication number: 20070036899Abstract: A water-resistant hydrophilic coating composition comprising a hydrophilic base material, an adhesion promoter, a surfactant and a crosslinking agent. A method of applying a water-resistant hydrophilic coating to a hydrophobic surface comprising; preparing the water-resistant hydrophilic coating, spraying the water-resistant hydrophilic coating on the hydrophobic surface and heating the coated surface. A method of water-proofing a polysaccharide coating comprising crosslinking the starch hydroxyl functionalities.Type: ApplicationFiled: August 12, 2005Publication date: February 15, 2007Applicant: Biotechnology Research and Development Corp.Inventors: Damodar Patil, George Fanta, Frederick Felker
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Patent number: 7160706Abstract: Plant material enriched in secondary metabolites is produced in tissue culture under conditions that organogenically produce a proliferation of shoots and leafy material, and harvesting the leafy material and shoots while in a green, actively-growing, non-senescent stage. Of particular interest is plant material that produces alkaloids, especially material from poppy (Papaver sp.) that will yield economically attractive levels of morphinane alkaloids, particularly thebaine.Type: GrantFiled: May 6, 2003Date of Patent: January 9, 2007Assignees: The United States of America as represented by the Secretary of Agriculture, The Biotechnology Research & Development Corp.Inventor: Brent H. Tisserat
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Publication number: 20060269679Abstract: A hydrophilic coating composition comprising a hydrophilic base material, an adhesion promoter and a surfactant. A method of applying a hydrophilic coating to a hydrophobic surface comprising preparing a hydrophilic coating, heating the hydrophilic coating and spraying the hydrophilic coating on the hydrophobic surface. A method of preparing a hydrophilic coating comprising preparing a solution of hydrophilic base material, heating the solution of hydrophilic base material and mixing at least a portion of the heated hydrophilic base material solution with an adhesion promoter and a surfactant.Type: ApplicationFiled: May 26, 2005Publication date: November 30, 2006Applicant: Biotechnology Research and Development Corp.Inventor: Damodar Patil
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Patent number: 6596923Abstract: The present invention provides non-invasive methods and compositions to differentiate, with a high level of sensitivity and specificity, swine that are genetically susceptible to diseases associated with F18 E. coli infection, from resistant swine. DNA polymorphisms in the swine alpha (1,2) fucosyltransferase 1 (FUT1) gene were used to differentiate resistant from susceptible swine. The invention includes a polypeptide with amino acid substitutions, encoded by the nucleotide polymorphisms, a molecular diagnostic assay, and a kit for the differentiation, of E. coli F18-adhesion resistant, heterozygous (carrier) and homozygous susceptible pigs. The molecular test identifies susceptibility to oedema disease and postweaning diarrhea with high sensitivity and specificity, therefore, is useful to swine breeder in their effort to enhance for resistance. Information on the polymorphisms of the present invention provides insight into causation and treatment of E. coli associated intestinal disorders.Type: GrantFiled: November 19, 1999Date of Patent: July 22, 2003Assignees: Biotechnology Research & Development Corp., The United States of America as represented by the Secretary of Agriculture, Swiss Federal Institute of TechnologyInventors: Brad T. Bosworth, Peter Vögeli
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Patent number: 6310136Abstract: Compositions of the invention are produced by blending hydroxy-functional polyesters with proteins at elevated temperatures. These compositions can be shaped into articles by known processes such as extrusion, compression molding, and injection molding. Among articles that can be made from such compositions are those with sufficiently strong tensile strengths as to form disposable utensils. However, the compositions are more environmentally friendly than commodity plastics such as polyethylene or polystyrene.Type: GrantFiled: July 28, 2000Date of Patent: October 30, 2001Assignees: The United States of America as represented by the Secretary of Agriculture, The Biotechnology Research & Development Corp.Inventors: Chaohua Wang, Craig J. Carriere
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Patent number: 6291582Abstract: A method of preparing a polymer-protein composite based upon placing a protein in solution in an organic phase via the ion-pairing of the protein with a surfactant. The polymer-protein composites are useful, for example, as highly active and stable catalysts, in for example, paints and coatings, as well as in medical application.Type: GrantFiled: November 10, 1999Date of Patent: September 18, 2001Assignee: Biotechnology Research & Development Corp.Inventors: Jonathan S. Dordick, Ping Wang, Maria Vladimir Sergeeva, Scott Joel Novick
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Patent number: 6040063Abstract: Articles are provided in which a self-supporting structure formed of natural polymer has a self-adherent, moisture resistant hydroxy-functional polyester on the structure surface. The self-supporting structure preferably is a starch and polyvinyl alcohol blend in an expanded form. The articles typically do not delaminate even when soaked in water, and are biodegradable.Type: GrantFiled: January 15, 1999Date of Patent: March 21, 2000Assignees: The United States of America as represented by the Secretary of Agriculture, Biotechnology Research & Development Corp.Inventors: William M. Doane, John W. Lawton, Jr., Randal Shogren
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Patent number: 6025417Abstract: Compositions of the invention include particular hydroxy-functional polyesters and a natural polymer. Among articles that can be made from such compositions are those with sufficiently strong tensile strengths as to form disposable utensils. However, the compositions are more environmentally friendly than commodity plastics such as polyethylene or polystyrene. Starches are particularly preferred as the natural polymers for inclusion in the compositions.Type: GrantFiled: September 8, 1997Date of Patent: February 15, 2000Assignees: Biotechnology Research & Development Corp., The United States of America as represented by the Secretary of the AgricultureInventors: Julious L. Willett, William M. Doane, Wayne Xu, Michael N. Mang, Jerry E. White
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Patent number: 5942435Abstract: Transgenic swine, and compositions and methods for making and using same, are provided. Central to the invention are porcine (Sus scrofa) embryonic stem cell lines and methods for establishing them. Cells of such lines are transformed with exogenous genetic material of interest and then used to provide chimeric swine, which have germ cells comprising the exogenous genetic material. The chimeric swine are bred to provide transgenic swine. Transgenic swine of the invention can be used to provide human proteins or peptide hormones or can be used as xenograft donors.Type: GrantFiled: June 6, 1995Date of Patent: August 24, 1999Assignees: The Board of Trustees of the University of Illinois, Biotechnology Research and Development Corp.Inventor: Matthew B. Wheeler
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Patent number: 5914367Abstract: A method of preparing a polymer-protein composite including polymerizing a monomer in the presence of a protein dissolved in an organic phase via the ion-pairing of the protein with a surfactant. The polymer-protein composites are useful, for example, as highly active and stable catalysts, in for example, paints and coatings, as well as in medical application.Type: GrantFiled: October 9, 1997Date of Patent: June 22, 1999Assignee: Biotechnology Research & Development Corp.Inventors: Jonathan S. Dordick, Ping Wang, Maria Vladimir Sergeeva, Scott Joel Novick
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Patent number: 5861216Abstract: Articles are provided in which a self-supporting structure formed of natural polymer has a self-adherent, moisture resistant hydroxy-functional polyester on the structure surface. The self-supporting structure preferably is a starch and polyvinyl alcohol blend in an expanded form. The articles typically do not delaminate even when soaked in water, and are biodegradable.Type: GrantFiled: June 28, 1996Date of Patent: January 19, 1999Assignees: The United States of America as represented by the Secretary of Agriculture, Biotechnology Research & Development Corp.Inventors: William M. Doane, John W. Lawton, Jr., Randal Shogren
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Patent number: 5719039Abstract: Organic enzyme solutions comprise an ion pair complex of an enzyme and a surfactant, and an organic solvent in which the enzyme-surfactant ion pair is dissolved. The solution has catalytic activity at least an order of magnitude greater than a suspension of an equal amount of the enzyme and organic solvent without ion pair complexes. The enzyme is preferably a hydrolase with an acyl transferase activity and the surfactant is Aerosol OT (sodium bis(2-ethylhexyl) sulfosuccinate) at low concentrations.Type: GrantFiled: June 1, 1995Date of Patent: February 17, 1998Assignees: University of Iowa Research Foundation, Biotechnology Research & Development Corp.Inventors: Jonathan S. Dordick, Vikram M. Paradkar
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Patent number: 5672621Abstract: Carbonarins A, B, C, D, E, F, G, and H have been isolated from the sclerotia of the fungus Aspergillus carbonarius. The carbonarius are effective for controlling Coleopteran and Lepidopteran insects. The carbonarins have the structure: ##STR1## wherein: R.sub.1 is a hydrogen atom or a hydroxy group; R.sub.2 is a hydrogen atom or a methoxy group; R.sub.3 is a hydrogen atom or a naphthopyrone group; and X is an oxygen atom or an NH group.Type: GrantFiled: February 27, 1996Date of Patent: September 30, 1997Assignees: The United States of America as represented by the Secretary of Agriculture, University of Iowa Research Foundation and Biotechnology Research and Development Corp.Inventors: Ali A. Alfatafta, Patrick F. Dowd, James B. Gloer, Donald T. Wicklow
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Patent number: 5523226Abstract: Transgenic swine, and compositions and methods for making and using same, are provided. Central to the invention are porcine (Sus scrofa) embryonic stem cell lines and methods for establishing them. Cells of such lines are transformed with exogenous genetic material of interest and then used to provide chimeric swine, which have germ cells comprising the exogenous genetic material. The chimeric swine are bred to provide transgenic swine. Transgenic swine of the invention can be used to provide human proteins or peptide hormones or can be used as xenograft donors.Type: GrantFiled: May 14, 1993Date of Patent: June 4, 1996Assignees: Biotechnology Research and Development Corp., Board of Trustees of the University of IllinoisInventor: Matthew B. Wheeler
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Patent number: 5519052Abstract: Carbonarins A, B, C, D, E, F, G, and H have been isolated from the sclerotia of the fungus Aspergillus carbonarius. The carbonarins are effective for controlling Coleopteran and Lepidopteran insects. The carbonarins have the structure: ##STR1## wherein: R.sub.1 is a hydrogen atom or a hydroxy group; R.sub.2 is a hydrogen atom or a methoxy group; R.sub.3 is a hydrogen atom or a naphthopyrone group; and X is an oxygen atom or an NH group.Type: GrantFiled: July 29, 1994Date of Patent: May 21, 1996Assignees: The United States of America as represented by the Secretary of Agriculture, University of Iowa Research Foundation and Biotechnology Research and Development Corp.Inventors: Ali A. Alfatafta, Patrick F. Dowd, James B. Gloer, Donald T. Wicklow
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Patent number: 5504366Abstract: A system for transporting in a vacuum chamber sample holders and samples between a holder tray and a location for use with a surface analytical instrument is disclosed. Also provided is a system including a microwave coaxial cable connecting the tip terminal of a scanning tunneling microscope to a microwave signal source and a system for clamping a heater to a sample holder in order to heat the sample.Type: GrantFiled: September 13, 1993Date of Patent: April 2, 1996Assignees: Biotechnology Research and Development Corp., Penn State Research FoundationInventors: Paul S. Weiss, Stephan J. Stranick