Abstract: Drug-dependent antibodies that bind to granulocytes, erythrocytes, platelets or membrane proteins derived from these cells, in the presence of a drug, but not in its absence, can be detected using a sensitive assay. Detection of the drug-dependent antibodies permits diagnosis of cytopenia mediated by the drug.
Type:
Grant
Filed:
September 15, 1993
Date of Patent:
December 17, 1996
Assignee:
The Blood Center of Southeastern Wisconsin, Inc.
Abstract: Isolated polynucleotide molecules, and peptides encoded by those molecules, can be used in the analysis of alloantigen phenotypes, as well as in diagnostic and therapeutic applications relating to human platelet Pl.sup.A polymorphism. In this vein, a method for typing blood cell and platelet membrane glycoproteins entails an analysis of amplified cDNA, encoded by platelet and red blood cell mRNA.
Type:
Grant
Filed:
April 27, 1989
Date of Patent:
February 25, 1992
Assignee:
The Blood Center of Southeastern Wisconsin, Inc.