Patents Assigned to The Board of Regent of the University of Oklahoma
  • Method and apparatus for predicting density of asphalt
    Patent number: 7669458
    Abstract: A method and apparatus for predicting the quality of compaction of beds of material with a vibratory device as a function of the vibration of the compaction device, the material of the bed, the lift thickness, the temperature, among other process parameters is described in this invention. The vibration of the compacting device during the compaction of the bed is compared with the vibration characteristics of the compacting device on a bed of known properties. The quality of compaction of the bed is then estimated based on the knowledge of the process parameters. The output of the apparatus may be used as a visual input to the operator of the compacting device or stored in an electronic format to depict the progress during the compaction process.
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: March 2, 2010
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Sesh Commuri, Musharraf Zaman
  • Enhancing the traffic carrying capacity of telecommunication networks
    Patent number: 7668135
    Abstract: The present invention relates to methods and systems for enhancing the traffic carrying capacity of telecommunication networks, in particular those involving optical networks and dense wavelength division multiplexing (DWDM).
    Type: Grant
    Filed: April 26, 2005
    Date of Patent: February 23, 2010
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Pramode K. Verma, Yingzhen Qu
  • Method for predicting sepsis or an acute infectious inflammatory response
    Patent number: 7655480
    Abstract: The present invention in one embodiment is an early detection marker for chronic or acute inflammatory-associated diseases. Chronic diseases may include atherosclerosis, Alzheimer's disease, asthma, rheumatoid arthritis, osteoarthritis, and inflammatory diseases of the bowel such as Crohn's disease, Ulcerative colitis, Irritable bowel syndrome and Inflammatory bowel disease. Acute diseases may include sepsis, acute systemic infections, acute lung injury, and acute respiratory distress syndrome.
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: February 2, 2010
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: H. Anne Pereira
  • Test cell for applying a shear stress to a test specimen
    Patent number: 7650795
    Abstract: A test cell and method for stress testing a test specimen including a first platen and a second platen. Each platen having a loading surface, an inclined surface, and a longitudinal axis. The inclined surface being inclined relative to the longitudinal axis at an angle and the inclined surface having a specimen recess formed therein for receiving a portion of the test specimen such that when the inclined surface of the second platen is positioned in a face-to-face relationship with the inclined surface of the first platen, a shear stress is applied to the test specimen when an axial load is applied to the first and second platens. The platens further including fluid ports to subject the test specimen to fluid flow at various pressures and fluid chemistries and ultrasonic transducers to determine acoustic, compressional, and shear wave velocities and in multiple orientations.
    Type: Grant
    Filed: March 10, 2008
    Date of Patent: January 26, 2010
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Younane Abousleiman, John Brumley, Vinh Ngyuen, Son K. Hoang, Ashraf Al-Tahini
  • Totally implantable hearing system
    Patent number: 7651460
    Abstract: A totally implantable hearing system having a sound processing device, a coil assembly, and a magnet assembly. The magnet assembly is implanted in the middle ear of a user and is in contact with at least a portion of an ossicle of the middle ear. The sound processing device receives and converts sound into an electrical signal. The coil assembly is preferably implanted within the bony canal wall adjacent the outer ear canal of the user such that at least a portion of the coil assembly extends into the middle ear space of the user.
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: January 26, 2010
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Rong Z. Gan
  • Methods of expressing gram-negative glycosaminoglycan synthase genes in gram-positive hosts
    Patent number: 7642071
    Abstract: The present invention relates to a Gram-negative glycosaminoglycan gene and methods of making and using same. The present invention relates to recombinant Gram-positive host cells containing a Gram-negative glycosaminoglycan synthase gene, and methods of producing glycosaminoglycans using such recombinant host cells.
    Type: Grant
    Filed: February 1, 2007
    Date of Patent: January 5, 2010
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Paul L. DeAngelis
  • METHOD OF USING CYTOKINE ASSAY TO DIAGNOSE, TREAT, AND EVALUATE INFLAMMATORY AND AUTOIMMUNE DISEASES
    Publication number: 20090325167
    Abstract: The invention provides methods for diagnosing, treating, or evaluating inflammatory and autoimmune diseases by sampling peripheral blood, serum, plasma, tissue, cerebrospinal fluit, or other bodily fluids from a human subject having a suspected diagnosis. The sample is analyzed for the presence and amount of certain cytokines, which provides the diagnosis, prognosis or evaluation of therapeutic response.
    Type: Application
    Filed: March 24, 2009
    Publication date: December 31, 2009
    Applicants: Board of Regents of the University of Oklahoma, Oklahoma Medical Research Foundation
    Inventors: Cherie M. Chappell, Michael B. Centola, Philip J. Alex, Kenneth Hensley
  • Genes of an otitis media isolate of nontypeable
    Patent number: 7638282
    Abstract: The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: December 29, 2009
    Assignees: Nationwide Children's Hospital, Inc., The Board of Regents of University of Oklahoma
    Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr., David W. Dyer
  • Compositions for treatment of inflammatory diseases
    Patent number: 7638507
    Abstract: Inflammatory bowel diseases are represented by two idiopathic disorders, which include ulcerative colitis and Crohn's disease. Ulcerative colitis is restricted to the colon and involves uncertain and inflammation of the lining (mucosa) of the large intestine. Crohn's disease, on the other hand, can involve the mucosa of the small and/or large intestine and may involve deeper layers of the bowel wall. The present invention is a combination of 5-aminosalicylic acid and one or more antioxidants (e.g., N-acetylcysteine) for treating such inflammatory bowel diseases.
    Type: Grant
    Filed: February 2, 2006
    Date of Patent: December 29, 2009
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Richard F. Harty
  • Treatment and inhibition of disease conditions using flexible heteroarotinoids
    Patent number: 7612107
    Abstract: The present invention contemplates methods of treating, reducing, inhibiting or preventing several diseases by the administration of flexible heteroarotinoids. Among the diseases or conditions which can benefit from treatment with flexible heteroarotinoids as described herein are, (1) cancers and other diseases that involve abnormal differentiation, (2) diabetes, (3) hemophilia, (4) liver disease, (5) diseases involving human aldehyde dehydrogenase 2, (6) polycystic kidney disease, (7) lysosomal storage diseases, (8) high cholesterol, (9) obesity, (10) high triglycerides, (11) glycoprotein metabolism diseases, and (12) diseases involving abnormal angiogenesis.
    Type: Grant
    Filed: April 14, 2006
    Date of Patent: November 3, 2009
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Doris M. Benbrook, Martin Turman, Suresh Guruswamy
  • DNA encoding hyaluronan synthase from and methods of use
    Patent number: 7604973
    Abstract: The present invention relates to a nucleic acid segment having a coding region segment encoding enzymatically active Pasteurella multocida hyaluronate synthase (PmHAS), and to the use of this nucleic acid segment in the preparation of recombinant cells which produce hyaluronate synthase and its hyaluronic acid product.
    Type: Grant
    Filed: May 1, 2007
    Date of Patent: October 20, 2009
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Paul DeAngelis
  • Method and apparatus for producing carbon nanotubes
    Patent number: 7585482
    Abstract: A method of purifying a single-walled carbon nanotube catalytic product having the steps of providing a catalytic product including single-walled carbon nanotubes, and a Group VIII and/or Group VIb transition metal, exposing the catalytic product to a heated oxidative gas to provide a treated carbon nanotube product including single-walled carbon nanotubes and the Group VIII and/or Group VIb transition metal, and exposing the treated carbon nanotube product to an acid to separate the single-walled carbon nanotubes from the Group VIII and/or Group VIb transition metal. The catalytic product may include a support material and amorphous carbon.
    Type: Grant
    Filed: October 17, 2005
    Date of Patent: September 8, 2009
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Daniel E. Resasco, Boonyarach Kitiyanan, Walter Alvarez, Leandro Balzano
  • Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using the same
    Patent number: 7579173
    Abstract: The present invention relates to methodology for polymer grafting by a polysaccharide synthase and, more particularly, polymer grafting using the hyaluronate or chondroitin or heparin/heparosan synthases from Pasteurella, in order to create a variety of glycosaminoglycan oligosaccharides having a natural or chimeric or hybrid sugar structure with a targeted size that are substantially monodisperse in size.
    Type: Grant
    Filed: January 9, 2007
    Date of Patent: August 25, 2009
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Paul L. DeAngelis, Wei Jing
  • Polymer grafting by polysaccharide synthases
    Patent number: 7575904
    Abstract: The present invention relates to methodology for polymer grafting by a polysaccharide synthase and, more particularly, polymer grafting using the hyaluronate synthase from Pasteurella multocida. The present invention also relates to coatings for biomaterials wherein the coatings provide protective properties to the biomaterial and/or act as a bioadhesive. Such coatings could be applied to electrical devices, sensors, catheters and any device which may be contemplated for use within a mammal. The present invention further relates to drug delivery matrices which are biocompatible and may comprise combinations of a biomaterial or a bioadhesive and a medicament or a medicament-containing liposome. The biomaterial and/or bioadhesive is a hyaluronic acid polymer produced by a hyaluronate synthase from Pasteurella multocida.
    Type: Grant
    Filed: July 11, 2005
    Date of Patent: August 18, 2009
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Paul L. DeAngelis
  • Method of identification of compounds effective against suppressed cancer cells
    Patent number: 7575926
    Abstract: A method for identifying compounds capable of targeting suppressed cancer cells, the method including the steps of comparing the response to a test compound of cancer cells grown on a suppressing cell support matrix which causes suppression of a malignant phenotype in a growing cancer cell and on a non-suppressing cell support matrix.
    Type: Grant
    Filed: December 19, 2006
    Date of Patent: August 18, 2009
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Robert E. Hurst, Michael A. Ihnat, Kimberly D. Kyker
  • Chondroitin synthase gene and methods of making and using same
    Patent number: 7569386
    Abstract: The present invention relates to a chondroitin synthase gene and methods of making and using same. In more particular, but not by way of limitation, the present invention relates to a chondroitin synthase gene from Pasteurella multocida and methods of isolating and using same. Additionally, the present invention relates to the use of unsulfated chondroitin and its preparation, as well as conversion into modified versions such as dermatan sulfate and chondroitin sulfate polymers.
    Type: Grant
    Filed: January 24, 2005
    Date of Patent: August 4, 2009
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Paul L. DeAngelis
  • Diagnostic method for screening complement regulatory protein levels to predict spontaneous abortion
    Patent number: 7566541
    Abstract: The invention provides a method for the early detection of pregnancy failure, spontaneous abortion or premature birth by determinations of complement regulatory protein levels. A kit for use in rapid identification of these pregnancy complications is also provided.
    Type: Grant
    Filed: January 13, 2006
    Date of Patent: July 28, 2009
    Assignee: Board of Regents of the University of Oklahoma
    Inventors: Mark G. Martens, Anil K. Kaul, Rashmi Kaul
  • Method of making carbon nanotubes
    Patent number: 7563428
    Abstract: A method of producing a carbon nanotube product comprising a catalytic particle and single-walled carbon nanotubes deposited thereon. The catalytic particles preferably contain at least one metal from Group VIII, including for example Co, Ni, Ru, Rh, Pd, Ir, and Pt, and at least one metal from Group VIb including for example Mo, W and Cr. The catalytic particle preferably further comprises a support material such as silica. The carbon nanotube product is preferably formed by exposing the catalytic particle to a carbon-containing gas at a temperature sufficient to form the single-walled nanotubes as a primary portion of a solid carbon product on the catalytic particles.
    Type: Grant
    Filed: January 24, 2006
    Date of Patent: July 21, 2009
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Daniel E. Resasco, Boonyarach Kitiyanan, Jeffrey H. Harwell, Walter Alvarez
  • Comparative ligand mapping from MHC positive cells
    Patent number: 7541429
    Abstract: The present invention relates generally to a methodology for the isolation, purification and identification of peptide ligands presented by MHC positive cells. In particular, the methodology of the present invention relates to the isolation, purification and identification of these peptide ligands from soluble class I and class II MHC molecules which may be uninfected, infected, or tumorgenic. The methodology of the present invention broadly allows for these peptide ligands and their comcomittant source proteins thereof to be identified and used as markers for infected versus uninfected cells and/or tumorgenic versus nontumorgenic cells with said identification being useful for marking or targeting a cell for therapeutic treatment or priming the immune response against infected cells.
    Type: Grant
    Filed: October 10, 2001
    Date of Patent: June 2, 2009
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: William H. Hildebrand, Heather D. Hickman
  • Volumetric liquid crystal display for rendering a three-dimensional image
    Patent number: 7537345
    Abstract: A volumetric liquid crystal display for producing a three-dimensional image is disclosed. The volumetric liquid crystal display includes a volumetric image space having at least two layers of LCD sheeting wherein each layer of LCD sheeting is selectively energized to form image slices. At least one projection system projects at least one array of electromagnetic energy of one or more wavelengths to intersect the energized layer of LCD sheeting illuminating image slices. Successive illumination of image slices on the layers of LCD sheeting provides the appearance of a three-dimensional image. Embodiments and methods of controlling and fabricating a three-dimensional image are disclosed.
    Type: Grant
    Filed: April 25, 2007
    Date of Patent: May 26, 2009
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Hakki H. Refai, Erik Petrich, James J. Sluss, Jr., Monte P. Tull, Pramode Verma