Patents Assigned to The Board of Regents for Northern Illinois University of DeKalb
  • HIV targeted hairpin ribozymes
    Patent number: 5869339
    Abstract: A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 9, 1999
    Assignees: The Board of Regents for Northern Illinois University of DeKalb, Biotechnology Research and Development Corporation
    Inventors: Arnold E. Hampel, Richard H. Tritz, Margaret F. Hicks
  • HIV targeted hairpin ribozymes
    Patent number: 5866701
    Abstract: A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.
    Type: Grant
    Filed: June 17, 1993
    Date of Patent: February 2, 1999
    Assignees: The Board of Regents for Northern Illinois University of DeKalb, Biotechnology Research and Development Corporation
    Inventors: Arnold E. Hampel, Richard H. Tritz
  • HIV targeted ribozymes
    Patent number: 5858785
    Abstract: A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 12, 1999
    Assignees: The Board of Regents for Northern Illinois University of DeKalb, Biotechnology Research and Development Corporation
    Inventors: Arnold E. Hampel, Richard H. Tritz
  • Hairpin ribozymes
    Patent number: 5856188
    Abstract: A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 5, 1999
    Assignees: The Board of Regents for Northern Illinois University of DeKalb, Biotechnology Research and Development Corporation
    Inventors: Arnold E. Hampel, Richard H. Tritz, Margaret F. Hicks
  • HIV targeted hairpin ribozymes
    Patent number: 5527895
    Abstract: A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst omprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.
    Type: Grant
    Filed: November 16, 1993
    Date of Patent: June 18, 1996
    Assignee: The Board of Regents for Northern Illinois University of DeKalb
    Inventors: Arnold E. Hampel, Richard H. Tritz