Abstract: A method of isotope enrichment comprises providing a mixture of at least two isotopic compounds of a reactant. One of the components having a greater percentage of a selected isotope than the other. An electron transfer agent is introduced into the mixture to form a reaction mixture. The electron transfer agent facilitates the transfer of electrons interactive with nuclei of the selected element in the reactant. The transfer agent is in an amount sufficient upon reaction of the reaction mixture to establish an equilibrium between an electron rich reaction product and an electron poor reaction product. The reaction mixture is reacted until the equilibrium is established. Molecules of the electron poor reaction product are then separated from molecules of the electron rich reaction product.